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Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease. Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important. .

Lipids. --- Lipides --- Lipins --- Lipoids --- Biomolecules --- Steroids --- Signal Transduction. --- Disease --- Therapeutics. --- etiology. --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Cell Signaling --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- therapy --- Lipid --- Pharmacology. --- Cancer research. --- Medical biochemistry. --- Pharmacology/Toxicology. --- Cancer Research. --- Medical Biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Lípids --- Malalties --- Malaltia --- Medicina --- Discapacitat física --- Malalties cardiovasculars --- Malalties constitucionals --- Malalties de l'aparell digestiu --- Malalties de l'aparell genital --- Malalties de l'aparell respiratori --- Malalties de la pell --- Malalties del sistema nerviós --- Malalties dels animals --- Malalties hematològiques --- Malalties hereditàries --- Malalties de l'aparell locomotor --- Malalties d'origen nutricional --- Malalties iatrogèniques --- Malalties immunitàries --- Malalties otorrinolaringològiques --- Malalties rares --- Oftalmopaties --- Serveis d'urgències mèdiques --- Síndromes --- Trastorns de la nutrició --- Trastorns del metabolisme --- Epidemiologia --- Lipoides --- Bioquímica --- Esfingolípids --- Fosfolípids --- Glicolípids --- Lípids de la sang --- Lipoproteïnes --- Membranes lipídiques --- Terpens --- Esteroides --- Metabolisme dels lípids