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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

stroke --- imaging --- machine learning --- ischemia --- perfusion

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Neurology & clinical neurophysiology --- stroke --- imaging --- machine learning --- ischemia --- perfusion

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Pharmacology --- drug discovery --- animal model --- neuropharmacology --- neurodegeneration --- brain ischemia --- addiction --- alzheimer's disease

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There has been an enormous increase in information relating to microRNA (miRNA) and its strategic role in numerous diseases. This book reviews the emerging role of microRNAs in cerebral ischemia, providing comprehensive details of the links between this small RNA molecule and ischemic stroke, the more prevalent of the two main types of stroke. The chapters address questions relating to microRNA’s function in various pathological features of stroke, like oxidative stress, excitotoxicity and cell death, as well as its role as a biomarker and diagnostic agent, and the current therapeutic interventions. Further, the book highlights the latest research on how miRNAs contribute to neuroregeneration following stroke, discussing the myriad computational tools and databases used in miRNA research, and decsribes how how miRNA modulates other cerebrovascular diseases. The book concludes with fresh insights into the effect of long non-coding RNA in cerebral ischemia.

Cerebral ischemia. --- Brain ischemia --- Cerebrovascular disease --- Ischemia --- Neurosciences. --- Human genetics. --- Immunology. --- Apoptosis. --- Oxidative stress. --- Human Genetics. --- Oxidative Stress. --- Oxidation-reduction reaction --- Stress (Physiology) --- Cell death --- Immunobiology --- Life sciences --- Serology --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Malalties cerebrovasculars --- RNA --- Expressió gènica --- Expressió dels gens --- Expressió genètica --- Expressivitat genètica --- Expressivitat gènica --- Ressenya genètica --- Regulació genètica --- Vectors genètics --- Àcid ribonucleic --- ARN --- Àcids nucleics --- Micro RNAs --- Accidents cerebrovasculars --- Accidents vasculars cerebrals --- Apoplexia --- AVC --- Ictus apoplèctic --- Insult apoplèctic --- Malalties vasculars cerebrals --- Patologia vascular cerebral --- Síndrome cerebrovascular --- Trastorns cerebrovasculars --- Malalties cerebrals --- Malalties vasculars --- Embòlia i trombosi cerebral --- Infart cerebral --- Isquèmia cerebral --- Paràlisi

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The book starts with the editors’ preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.

Research & information: general --- Biology, life sciences --- ascorbic acid --- deferoxamine --- N-acetylcysteine --- ischemia/reperfusion --- cardiac fibroblasts --- reactive oxygen species --- photobiomodulation --- reactive oxygen species (ROS) --- nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) --- cancer --- diabetes --- wound healing --- glucose --- pentose phosphate pathway --- NADPH --- redox balance --- glycogen --- glycolysis --- stress resistance --- insulin resistance --- immunomodulation --- inflammation --- olive tree --- oxidative stress --- secoirioids --- sirtuin 3 --- high fat diet --- sex differences --- mice --- metabolic stress --- antioxidants --- ADHD --- Nrf2 --- NRF2-KEAP1 --- ROS --- cancer metabolism --- antioxidant --- cancer therapy --- chemoresistance --- radioresistance --- sepsis --- MitoVitE --- mitochondria --- gene expression --- cytokines --- mRNA --- vitamin C --- folic acid --- one-carbon metabolism --- C2C12 cells --- metabolomics --- mass spectrometry --- type 2 diabetes --- dipeptidyl peptidase-4 inhibitors --- biomarkers --- ER stress --- Ezetimibe --- ischemia-reperfusion --- ionizing radiation --- liver --- hydroperoxide --- epigenetics --- miR7/MAFG/Nrf2 axe --- n/a