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Cox --- David --- 1783-1859

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Women human rights workers --- Human rights workers --- Défenseuses des droits de l'homme --- Défenseurs des droits de l'homme --- Cox, Caroline, --- Cox, Caroline, --- Great Britain.

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Offering a complete survey of Georgia O'Keeffe's illustrious career, this magnificent new book ranges from the works produced between 1910 and 1920 that made her a pioneer of abstraction to her celebrated flower paintings and views of New York, which led to her recognition as one of the key figures in modern American art, and culminating with her paintings of New Mexico. The selection of color plates is accompanied by quotes from O'Keeffe on her art and additional photographic material pertaining to the paintings. The sense of reverence for the world and its forms emerges vividly through O'Keeffe's words. "The unexplainable thing in nature that makes me feel the world is big far beyond my understanding--to understand maybe by trying to put it into form," she writes. "To find the feeling of infinity on the horizon line or just over the next hill." Also featured are a biography and texts by contributing curators from the venues to which the show travels, by scholars at the Georgia O'Keeffe Museum in Santa Fe and by acclaimed French art writer Catherine Millet.

O'Keeffe, Georgia --- Schilderkunst --- Verenigde Staten --- 20e eeuw --- Kunst --- Women painters --- Painting, Modern --- 75.07 --- Painters --- Women artists --- United States --- Schilderkunst--schilders --- O'Keeffe, Georgia, --- Stieglitz, Georgia O'Keeffe, --- O'Keefe, Georgia, --- O'Keeffe, Georgia Totto, --- Stieglitz, Alfred, --- Chase, William Merritt, --- Cox, Kenyon, --- Mora, F. Luis --- Exhibitions --- O'Keeffe, Georgia 1887-1986 (°Sun Prairie, Wisconsin, Verenigde Staten) --- Schilderkunst ; 20ste eeuw ; Georgia O'Keeffe --- Vrouwelijke kunstenaars --- Precisionisme --- Painting --- 75.071 --- schilders --- abstracte kunst --- schilderkunst --- Georgia O'Keeffe

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Natural-based biomolecules continuously play an important role in novel drug discovery for the treatment of chronic diseases. The development of natural peptide/protein-based, toxin-based, and antibody-based drugs can significantly improve the biomedical efficiency of disease-specific therapy. The focus of this Special Issue of Biomolecules will be on the most recent advances related to novel peptides/proteins, antibodies, and toxins as forms of medicinal therapy. Recent advances in the discovery and development of these natural biomolecules for use in targeted therapy and immunotherapy against chronic diseases (e.g., cancer, diabetes, cardiovascular diseases, and rheumatoid arthritis) will be addressed. The discussion on using novel disease-specific proteins/peptides/toxins/antibodies along with currently available FDA-approved drugs as combinatorial treatments will also be encouraged in this context. Finally, an overview of some of the selected promising natural biomolecules that are potentially able to address the forthcoming challenges in this field will be included. Both research (in particular) and review articles proposing novelties or overviews, respectively, are welcome.

Humanities --- Social interaction --- DAPK1 --- SUMO --- SENP --- protein degradation --- post-translational modification --- amphibian Bowman-Birk inhibitor --- Tat peptide --- molecular cloning --- antifungal --- drug design --- protease inhibitor --- natural-based compound --- anticancer therapy --- lung cancer --- survivin --- apoptosis --- STAT3 --- colorectal cancer --- orientin --- cell cycle arrest --- Bcl-2 family proteins --- Astragalus membranaceus --- insulin --- PI3K --- AKT --- PPARγ --- PDX-1 --- Petasites japonicus --- Asteraceae --- lignan --- anti-inflammation --- NO --- PGE2 --- iNOS --- COX-2 --- molecular docking --- peptides --- kynurenines --- binding affinity --- μ-opioid receptor --- pharmacophore --- G-protein activation --- fucoidan --- PLGA --- docetaxel --- drug delivery system --- anticancer therapy/cancer treatment --- hIAPP --- amyloidogenesis --- insulin granules --- endoplasmic reticulum --- anionic lipids --- F23R variant --- β-sheet transitions --- β-cell cytotoxicity --- unfolded protein response --- pomegranate --- punicalagin --- tannins --- gingiva --- fibroblasts --- antioxidant --- wound healing --- branched-chain fatty acids --- Conidiobolus heterosporus --- peroxisome proliferator-activated receptor α --- lipid metabolism --- fatty acid oxidation --- hepatocyte --- n/a

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This book contains 12 articles covering biomedicine, nutrition, and the methodology of lipidomics . These works were first published by MDPI in a Special Issue of Metabolites. Phospholipids, sphingolipids, glyosylinositolphosphoceramides, cholesteryl esters, acyl-carnitines, and oxylipins are within the lipid classes accounted for studies regarding liver disease, Wilson disease, kidney disease, cardiovascular disease, adipogenesis, and the role lipids play in cancer and virus infection. High-throughput lipid extraction and guidelines for lipid annotation are addressed in several papers. This book is expected to provide a comprehensive view of the diverse areas where lipidomics looms largest.

Research & information: general --- chronic kidney disease --- leptin --- fatty acids --- adipose tissue --- adipocytes --- adipogenesis --- differential mobility spectrometry (DMS) --- lipidomics --- lipidyzer --- mass spectrometry --- metabolomics --- phenotyping --- Simpson-Golabi-Behmel syndrome (SGBS) --- COX --- CYP450 --- LOX --- oxylipins --- PUFAs --- UPLC-MS/MS --- copper --- Wilson’s disease --- lipidomic --- liquid chromatography --- tandem mass spectrometry --- molecular network --- dry eye disease --- hyperosmolarity --- cardiovascular disease --- heart failure --- myocardial infarction --- obesity --- diabetic cardiomyopathy --- dilated cardiomyopathy --- lipids --- odd chain lipids --- lipid profiling --- Folch --- protein precipitation --- sample preparation --- relative lipid composition (Mol%) --- atopic dermatitis --- SHARPIN-deficient mice --- flow-injection mass-spectrometry --- predictive elastic net --- immunotherapy --- cancer --- biomarkers --- metabolism --- cancer cell membranes --- fatty acid biosynthesis --- essential fatty acids --- desaturase enzymes --- fatty acid signaling --- fatty acid biomarker --- sapienic acid --- sebaleic acid --- molecular nutrition --- inflammation --- drug-induced liver injury --- biomarker --- plasma lipid profiles --- ssRNA+ virus --- membrane fusion --- lipid metabolism --- cholesterol --- sphingolipids --- phosphatidylinositol --- SARS-CoV --- glycolipidomics --- GIPC --- glycosyl inositol phospho ceramides --- Lipid Data Analyzer --- ultra-high pressure liquid chromatography --- high-resolution mass spectrometry --- LC-MS --- automated annotation