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Membranes (Biology) --- Lipoproteins --- Lipids --- Metabolism. --- Lipid metabolism --- Proteins --- Biological membranes --- Biomembranes --- Biological interfaces --- Protoplasm --- Lipid Metabolism --- Metabolism, Lipid --- metabolism

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This fully updated edition targets not only those assays directly involved in the discovery of GPCR-active compounds but also those involved in cell-based experiments designed to study physiological responses. Whether coming from academia or industry, or being an experienced researcher or a newcomer to the field, the reader will find accessible methods and protocols that cover the latest developments on receptor purification, molecular biology, recombinant engineering, and analytical techniques that enable the real time monitoring of the complex GPCR signaling cascade and identification of potential drug targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, G Protein-Coupled Receptor Screening Assays: Methods and Protocols, Second Edition aims to provide the tools necessary to contribute to the advancement of GPCR research and discovery and ultimately lead to the availability of innovative and more efficient drugs.

Biological transport. --- Cell membranes. --- Pharmacology. --- Chemistry. --- Membrane Trafficking. --- Physical sciences --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Membrane transport --- Passive transport, Biological --- Physiological transport --- Transport, Biological --- Diffusion --- Osmosis --- Physiological effect

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The field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implications of EVs in intercellular communication and the significance of biologically active cargo carried within these EVs are further examined. Moreover, the numerous applications of EVs in diagnostics and treatment of diseases are reviewed in detail, particularly their potential as biomarkers and drug delivery vehicles. Taken together, this book is a compilation of the key implications of EVs that are secreted by virtually all cell types. Readers will gain a perspective into the biology, functions and applications of EVs and their constantly evolving knowledge base.

Extracellular space. --- Extracellular fluid space --- Body fluids --- Espai extracel·lular --- Fluid extracel·lular --- Humors corporals --- Biological transport. --- Cell membranes. --- Cytology. --- Biochemistry. --- Diseases. --- Membrane Trafficking. --- Cell Biology. --- Mechanisms of Disease. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Medicine --- Epidemiology --- Health --- Pathology --- Sick --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Membrane transport --- Passive transport, Biological --- Physiological transport --- Transport, Biological --- Diffusion --- Osmosis --- Diseases --- Composition