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Embriologia --- Desenvolupament embriològic --- Desenvolupament embrional --- Embriogènesi --- Embriogènia --- Embriologia animal --- Biologia --- Evolució --- Morfologia animal --- Edat gestacional --- Epigènesi --- Cèl·lules germinals --- Cordó umbilical --- Diferenciació sexual --- Fetus --- Gametogènesi --- Genètica del desenvolupament --- Miogènesi --- Neurobiologia del desenvolupament --- Òvuls --- Placenta --- Teratologia --- Biologia del desenvolupament --- Cèl·lules --- Protoplasma --- Reproducció --- Placenta. --- Mammals --- Reproduction. --- Cotyledon (Anatomy) --- Embryology --- Uterus, Pregnant
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From Homer to the Bible, and Aristotle to Descartes, expert and common knowledge held that a pregnant woman's emotions and experiences could "imprint" on the fetus, leading to features such as birthmarks, deformities, and distinctive personality traits. Beginning with the advent of modern genetics at the turn of the twentieth century, however, biomedical scientists dismissed any notion that a mother-except in cases of extreme deprivation or injury-could alter her offspring's traits. Consensus asserted that the fetus was walled off from a woman's body by the placenta and that a child's fate was set by a combination of its genes and post-birth upbringing. Over the last fifty years, this consensus was dismantled. Today, research on the intrauterine environment and its effects on the fetus is emerging as a robust program of study in medicine, public health, psychology, evolutionary biology, and genomics. Some researchers claim that these maternal effects represent a biologically important but non-genetic form of inheritance, potentially refracting the mother's experiences and exposures across generations of descendants. Tracing a genealogy of ideas about heredity and maternal-fetal effects, The Maternal Imprint offers a critical analysis of conceptual and ethical issues provoked by the striking rise of epigenetics and fetal origins science in postgenomic biology today.
Fetus --- Maternal-fetal exchange --- Mother and infant --- Infant and mother --- Mother-infant relationship --- Mother and child --- Placenta --- Pregnancy --- Fetal development --- Intrauterine development --- Developmental biology --- Development --- Human genetics --- Genetics --- History --- Medical sciences --- Motherhood --- Science --- Book
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Stem cells. --- Veterinary embryology. --- Embryology --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Cèl·lules mare embrionàries --- Embriologia --- Desenvolupament embriològic --- Desenvolupament embrional --- Embriogènesi --- Embriogènia --- Embriologia animal --- Biologia --- Evolució --- Morfologia animal --- Edat gestacional --- Epigènesi --- Cèl·lules germinals --- Cordó umbilical --- Diferenciació sexual --- Fetus --- Gametogènesi --- Genètica del desenvolupament --- Miogènesi --- Neurobiologia del desenvolupament --- Òvuls --- Placenta --- Teratologia --- Biologia del desenvolupament --- Cèl·lules --- Protoplasma --- Reproducció --- Cèl·lules mare
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In this Special Issue, we focus on maternal docosahexaenoic acid, 22:6n-3 (DHA), and arachidonic acid, 20:4n-6 (ARA), on children’s neurodevelopment. During the last trimester of gestation and for the first 18 months after birth, both DHA and ARA are preferentially deposited within the cerebral cortex at a rapid rate. The mode of action of these two fatty acids and their derivatives at different structural–functional roles, and their levels in the signaling pathways of the brain have been continuously studied. These fatty acids are also involved in various brain developmental processes; however, their mechanistic cross talks are not yet clearly known. Recent data suggest that there may be a need for a balanced proportion of ARA and DHA in infant formula due to their complementary benefits. This review describes the importance of ARA in addition to DHA to support optimal brain development and growth in an infant, and functional roles in the brain.
maternal supplementation --- pregnancy --- lactation --- docosahexaenoic acid (DHA) --- neurodevelopment --- randomized controlled trial (RCT) --- India --- DHA --- brain --- MFSD2a --- SPM --- fetus --- placenta --- infant --- neurogenesis --- pre-term --- docosahexaenoic acid --- supplementation --- egg yolk --- microalgae --- long chain omega-3 fatty acids --- pregnancy outcomes --- anthropometry --- birth weight --- birth length --- head circumference --- arachidonic acid,20:4n-6 --- docosahexaenoic acid,22:6n-3 --- maternal diet --- cognitive --- infants --- n/a
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In this Special Issue, we focus on maternal docosahexaenoic acid, 22:6n-3 (DHA), and arachidonic acid, 20:4n-6 (ARA), on children’s neurodevelopment. During the last trimester of gestation and for the first 18 months after birth, both DHA and ARA are preferentially deposited within the cerebral cortex at a rapid rate. The mode of action of these two fatty acids and their derivatives at different structural–functional roles, and their levels in the signaling pathways of the brain have been continuously studied. These fatty acids are also involved in various brain developmental processes; however, their mechanistic cross talks are not yet clearly known. Recent data suggest that there may be a need for a balanced proportion of ARA and DHA in infant formula due to their complementary benefits. This review describes the importance of ARA in addition to DHA to support optimal brain development and growth in an infant, and functional roles in the brain.
Medicine --- maternal supplementation --- pregnancy --- lactation --- docosahexaenoic acid (DHA) --- neurodevelopment --- randomized controlled trial (RCT) --- India --- DHA --- brain --- MFSD2a --- SPM --- fetus --- placenta --- infant --- neurogenesis --- pre-term --- docosahexaenoic acid --- supplementation --- egg yolk --- microalgae --- long chain omega-3 fatty acids --- pregnancy outcomes --- anthropometry --- birth weight --- birth length --- head circumference --- arachidonic acid,20:4n-6 --- docosahexaenoic acid,22:6n-3 --- maternal diet --- cognitive --- infants --- maternal supplementation --- pregnancy --- lactation --- docosahexaenoic acid (DHA) --- neurodevelopment --- randomized controlled trial (RCT) --- India --- DHA --- brain --- MFSD2a --- SPM --- fetus --- placenta --- infant --- neurogenesis --- pre-term --- docosahexaenoic acid --- supplementation --- egg yolk --- microalgae --- long chain omega-3 fatty acids --- pregnancy outcomes --- anthropometry --- birth weight --- birth length --- head circumference --- arachidonic acid,20:4n-6 --- docosahexaenoic acid,22:6n-3 --- maternal diet --- cognitive --- infants
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The materials published in the Special Issue reflect the real diversity of echinoderm metabolites and cover most of their specific classes and biomedical potential as antioxidant, antiviral, anticancer, and even anticoagulant preparations. The metabolites include sea urchin naphtoquinoid pigments and their semi-synthetic derivatives, sea cucumber triterpene glycosides, esters of polyhydroxysteroids from starfish, sea urchins free sterols, and sea cucumber fucosylated chondroitin sulfates. This Special Issue, “Echinoderm Metabolites: Structure, Functions, and Biomedical Perspectives”, is a collection of articles about different scientific aspects concerning low molecular weight and biopolymer metabolites from echinoderms, including their isolation and chemical structures, biological activities, biosynthesis and evolution, biological functions, and obtaining of semi-synthetic derivatives of biologically active natural products. This Special Issue includes materials about sea urchin naphtoquinoid pigments and their semi-synthetic derivatives, sea cucumber triterpene glycosides, esters of polyhydroxysteroids from starfish, sea urchin free sterols, and sea cucumber fucosylated chondroitin sulfates.
prostate cancer --- thioglucoside conjugates --- natural products --- sea urchins --- glucose uptake --- polyhydroxysteroidal esters --- NMR spectra --- fatty acids --- starfish --- Ceramaster patagonicus --- cytostatic activity --- soft agar assay --- wound healing assay --- Colochirus quadrangularis --- triterpene glycosides --- quadrangularisosides --- sea cucumber --- cytotoxic activity --- Holothuria hilla --- Paracaudina chilensis --- fucosylated chondroitin sulfate --- anticoagulant activity --- echinochrome A --- echinamine A --- echinamine B --- herpes simplex virus type 1 --- Vero cells --- glycoprotein gD --- molecular docking --- Thyonidium kurilensis --- kurilosides --- Thenea muricata --- Aplysina sp. --- Pseudoanthomastus agaricus --- Montastraea cavernosa --- Buccinum sp. --- Pasiphaea tarda --- Phormosoma placenta --- Echinometra lucunter --- sterols --- gas chromatography --- mass spectrometry --- neuroblastoma Neuro-2a cells --- 5,8-dihydroxy-1,4-naphthoquinone --- O-glucoside --- thiomethylglycoside --- QSAR --- n/a
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Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV–host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design.
Research & information: general --- Biology, life sciences --- Zika virus --- peroxisomes --- innate immune response --- interferon --- astrocytes --- fetal brain --- zika virus --- flaviviruses --- T cells --- host-pathogen interactions --- flavivirus --- tight junctions --- claudins --- ZO-1 --- blood-placental barrier --- placenta --- apoptosis --- viral replication --- Bcl-2 protein family --- ZIKV --- virus host interactions --- pathogenesis --- MR766 --- guinea pig --- subcutaneous --- vaginal --- sexual transmission --- virus transmission --- envelope protein --- glycosylation --- fusion loop --- viral fusion --- cell entry --- NS5 protein --- nuclear localization --- inflammation --- innate immunity --- extracellular vesicles --- cellular communication --- C6/36 cells --- human monocytes --- endothelial vascular cells --- protein–protein interaction --- non-structural viral proteins --- network --- JAK/STAT --- cytokine --- West Nile virus --- HSP90 --- NS5 --- virus–host interactions --- anti-viral signaling --- immune response --- inflammatory mediator --- Sertoli cells --- Leydig cells --- ZIKA virus --- arboviruses --- infertility --- IFN --- RIG-I --- MDA5 --- IFNAR1 --- zika --- host --- cell death --- peroxisome --- mosquito --- tight junction --- Zika virus --- peroxisomes --- innate immune response --- interferon --- astrocytes --- fetal brain --- zika virus --- flaviviruses --- T cells --- host-pathogen interactions --- flavivirus --- tight junctions --- claudins --- ZO-1 --- blood-placental barrier --- placenta --- apoptosis --- viral replication --- Bcl-2 protein family --- ZIKV --- virus host interactions --- pathogenesis --- MR766 --- guinea pig --- subcutaneous --- vaginal --- sexual transmission --- virus transmission --- envelope protein --- glycosylation --- fusion loop --- viral fusion --- cell entry --- NS5 protein --- nuclear localization --- inflammation --- innate immunity --- extracellular vesicles --- cellular communication --- C6/36 cells --- human monocytes --- endothelial vascular cells --- protein–protein interaction --- non-structural viral proteins --- network --- JAK/STAT --- cytokine --- West Nile virus --- HSP90 --- NS5 --- virus–host interactions --- anti-viral signaling --- immune response --- inflammatory mediator --- Sertoli cells --- Leydig cells --- ZIKA virus --- arboviruses --- infertility --- IFN --- RIG-I --- MDA5 --- IFNAR1 --- zika --- host --- cell death --- peroxisome --- mosquito --- tight junction
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The materials published in the Special Issue reflect the real diversity of echinoderm metabolites and cover most of their specific classes and biomedical potential as antioxidant, antiviral, anticancer, and even anticoagulant preparations. The metabolites include sea urchin naphtoquinoid pigments and their semi-synthetic derivatives, sea cucumber triterpene glycosides, esters of polyhydroxysteroids from starfish, sea urchins free sterols, and sea cucumber fucosylated chondroitin sulfates. This Special Issue, “Echinoderm Metabolites: Structure, Functions, and Biomedical Perspectives”, is a collection of articles about different scientific aspects concerning low molecular weight and biopolymer metabolites from echinoderms, including their isolation and chemical structures, biological activities, biosynthesis and evolution, biological functions, and obtaining of semi-synthetic derivatives of biologically active natural products. This Special Issue includes materials about sea urchin naphtoquinoid pigments and their semi-synthetic derivatives, sea cucumber triterpene glycosides, esters of polyhydroxysteroids from starfish, sea urchin free sterols, and sea cucumber fucosylated chondroitin sulfates.
Medicine --- prostate cancer --- thioglucoside conjugates --- natural products --- sea urchins --- glucose uptake --- polyhydroxysteroidal esters --- NMR spectra --- fatty acids --- starfish --- Ceramaster patagonicus --- cytostatic activity --- soft agar assay --- wound healing assay --- Colochirus quadrangularis --- triterpene glycosides --- quadrangularisosides --- sea cucumber --- cytotoxic activity --- Holothuria hilla --- Paracaudina chilensis --- fucosylated chondroitin sulfate --- anticoagulant activity --- echinochrome A --- echinamine A --- echinamine B --- herpes simplex virus type 1 --- Vero cells --- glycoprotein gD --- molecular docking --- Thyonidium kurilensis --- kurilosides --- Thenea muricata --- Aplysina sp. --- Pseudoanthomastus agaricus --- Montastraea cavernosa --- Buccinum sp. --- Pasiphaea tarda --- Phormosoma placenta --- Echinometra lucunter --- sterols --- gas chromatography --- mass spectrometry --- neuroblastoma Neuro-2a cells --- 5,8-dihydroxy-1,4-naphthoquinone --- O-glucoside --- thiomethylglycoside --- QSAR --- prostate cancer --- thioglucoside conjugates --- natural products --- sea urchins --- glucose uptake --- polyhydroxysteroidal esters --- NMR spectra --- fatty acids --- starfish --- Ceramaster patagonicus --- cytostatic activity --- soft agar assay --- wound healing assay --- Colochirus quadrangularis --- triterpene glycosides --- quadrangularisosides --- sea cucumber --- cytotoxic activity --- Holothuria hilla --- Paracaudina chilensis --- fucosylated chondroitin sulfate --- anticoagulant activity --- echinochrome A --- echinamine A --- echinamine B --- herpes simplex virus type 1 --- Vero cells --- glycoprotein gD --- molecular docking --- Thyonidium kurilensis --- kurilosides --- Thenea muricata --- Aplysina sp. --- Pseudoanthomastus agaricus --- Montastraea cavernosa --- Buccinum sp. --- Pasiphaea tarda --- Phormosoma placenta --- Echinometra lucunter --- sterols --- gas chromatography --- mass spectrometry --- neuroblastoma Neuro-2a cells --- 5,8-dihydroxy-1,4-naphthoquinone --- O-glucoside --- thiomethylglycoside --- QSAR
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Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV–host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design.
Research & information: general --- Biology, life sciences --- Zika virus --- peroxisomes --- innate immune response --- interferon --- astrocytes --- fetal brain --- zika virus --- flaviviruses --- T cells --- host-pathogen interactions --- flavivirus --- tight junctions --- claudins --- ZO-1 --- blood-placental barrier --- placenta --- apoptosis --- viral replication --- Bcl-2 protein family --- ZIKV --- virus host interactions --- pathogenesis --- MR766 --- guinea pig --- subcutaneous --- vaginal --- sexual transmission --- virus transmission --- envelope protein --- glycosylation --- fusion loop --- viral fusion --- cell entry --- NS5 protein --- nuclear localization --- inflammation --- innate immunity --- extracellular vesicles --- cellular communication --- C6/36 cells --- human monocytes --- endothelial vascular cells --- protein–protein interaction --- non-structural viral proteins --- network --- JAK/STAT --- cytokine --- West Nile virus --- HSP90 --- NS5 --- virus–host interactions --- anti-viral signaling --- immune response --- inflammatory mediator --- Sertoli cells --- Leydig cells --- ZIKA virus --- arboviruses --- infertility --- IFN --- RIG-I --- MDA5 --- IFNAR1 --- zika --- host --- cell death --- peroxisome --- mosquito --- tight junction
Choose an application
Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV–host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design.
Zika virus --- peroxisomes --- innate immune response --- interferon --- astrocytes --- fetal brain --- zika virus --- flaviviruses --- T cells --- host-pathogen interactions --- flavivirus --- tight junctions --- claudins --- ZO-1 --- blood-placental barrier --- placenta --- apoptosis --- viral replication --- Bcl-2 protein family --- ZIKV --- virus host interactions --- pathogenesis --- MR766 --- guinea pig --- subcutaneous --- vaginal --- sexual transmission --- virus transmission --- envelope protein --- glycosylation --- fusion loop --- viral fusion --- cell entry --- NS5 protein --- nuclear localization --- inflammation --- innate immunity --- extracellular vesicles --- cellular communication --- C6/36 cells --- human monocytes --- endothelial vascular cells --- protein–protein interaction --- non-structural viral proteins --- network --- JAK/STAT --- cytokine --- West Nile virus --- HSP90 --- NS5 --- virus–host interactions --- anti-viral signaling --- immune response --- inflammatory mediator --- Sertoli cells --- Leydig cells --- ZIKA virus --- arboviruses --- infertility --- IFN --- RIG-I --- MDA5 --- IFNAR1 --- zika --- host --- cell death --- peroxisome --- mosquito --- tight junction
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