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Anti-infective agents are a distinct class of pharmacologically important molecules that have served mankind in different capacities to combat life-threatening pathological conditions. They include antibacterial, antifungal, antiviral, antituberculosis, antimalarial and urinary anti-infective agents. However, evolutionary changes, adaptations and development of new strains of pathogenic microorganisms that have reduced the therapeutic efficacy of existing drugs, thus, limiting their clinical utility over the years. Frontiers in Anti-Infective Agents Volume 6 is a collection of notable research efforts, successful anti-infective drug development programmes and a comprehensive overview of successful and unsuccessful clinical trials conducted in this domain. This volume continues from the last one with interesting reviews on: 1) "Reverse Vaccinology" for vaccination design using computational data to identify vaccine targets, 2) leptospirosis, 3) phage therapy for bacterial infections, 4) quorum sensing inhibitors from natural products, and 5) nitrogen and oxygen based heterocyclic compounds that can act as anti-infective agents. The volume, therefore, covers a range of frontier topics on anti-infective research and development.This compilation is a timely reference for postgraduate scholars and researchers seeking updates in specific areas of anti-infective drug development. Allied healthcare professionals (clinical and public healthcare professionals) can also benefit from the information presented within.

Anti-infective agents. --- Communicable diseases in pregnancy. --- Pregnancy --- Antiinfective agents --- Antimicrobial agents --- Antimicrobial drugs --- Antimicrobials --- Drugs --- Complications

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Among neurodegenerative diseases, those that lead to a state ofdementia are the aim of severalinvestigations. Dementia is a chronic disease the prevalence of whichis increasing worldwide. Thenumber of dementia patients in the world is approximately 50 million,and it is estimated that thenumber of patients will reach 131.5 million by 2050. This increase willbe accompanied by asignificant increase in medical expenditures and other expenses,especially for elderly patients.Therefore, the maintenance cost of dementia in the future is expectedto be quite high. For thisreason, several investigations aim, firstly, to describe the keymechanisms involved in the originof dementia and, secondly, to establish preventive and therapeuticstrategies in order tounderstand and mitigate this debilitating pathology. This volume of Frontiers in Clinical Drug Research -Dementia explores the current comorbidities that cause cognitiveimpairment and the current management alternatives for clinical cases ofdementia. The reviews contributed in these volume will provide readers with acurrent perspective on the subject. The topics covered in this volume include:- Comorbidities inducing mild cognitive impairment - an evaluation ofthe risk caused by some pathological conditions- Tau-targeted therapy in Alzheimer's disease - history and currentstate- Emerging nanotherapeutic strategies in Alzheimer's disease- Implication of dehydroepiandrosterone on dementia related tooxidative stress- Polyphenol compounds as potential therapeutic agents in Alzheimer'sdisease The volume is a timely update on dementia treatment for clinicalphysicians, neurologists, gerontologists, pharmaceutical and medicinal chemistryresearchers, and physiologists.

Anti-infective agents. --- Medical innovations. --- Anti-inflammatory agents. --- Anti-inflammatories --- Antiinflammatory agents --- Antiphlogistics --- Antipyretics --- Inflammation --- Innovations, Medical --- Medicine --- Medical technology --- Technological innovations --- Antiinfective agents --- Antimicrobial agents --- Antimicrobial drugs --- Antimicrobials --- Drugs --- Innovations

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The importance of understanding metal–microbe interactions underlies a number of social–economic issues in the world. The antimicrobial resistance era has created a need for novel antimicrobials and within this fieldm metal and metalloid ions are promising solutions. Pollution sites, either co-contaminated with metals or with metals as the sole pollutant, contain microbes that are present as key participants, with both of these issues habing links to agriculture. Microbes also play key roles in the global geochemical cycle of many elements. Such statements solidify the need to understand metal–microbe interactions. Given that genomics has arguably become the most useful tool in biology, the application of this technology within the field of understanding metal resistance comes as no surprise. Whilst by no means comprehensive, this book provides examples of the applications of genomic approaches in the study of metal–microbe interactions. Here, we present a collection of manuscripts that highlights some present directions in the field. The book starts with a collection of three papers evaluating aspects of the genomics of the archetype metal resistant bacteria, Cuprividus metallidurans. This is followed by four studies that evaluate the mechanisms of metal resistance. The next two papers assess metal resistance in agricultural related situations, including a review on metal resistance in Listeria. The book concludes with a review on metal phytoremediation via Rhizobia and two subsequent studies of metal biotechnology relevance.

Research & information: general --- Biology, life sciences --- silver --- silver toxicity --- silver resistance --- Keio collection --- Escherichia coli --- antimicrobials --- Acidithiobacillus ferrooxidans --- copper resistance --- biomining --- envelope components --- proteomics --- lipopolysaccharide --- genomic island --- integrase --- Acinetobacter baumannii --- mobile genetic element --- Ensifer (Sinorhizobium) sp. M14 --- arsenic-oxidizing bacteria --- heavy metal resistance --- draft genome sequence --- comparative genomic analysis --- biosafety --- biotechnology for arsenic removal --- adsorption --- water treatment --- in situ (bio)remediation --- copper --- resistance --- swine --- phenotype microarray --- mobile genetic elements --- Cupriavidus --- metal --- soil bioremediation --- heavy-metals --- serpentine soils --- serpentine vegetation --- genome manipulation --- cis-hybrid strains --- heavy metals --- genomic islands --- genomic rearrangements --- metal resistance genes --- Mucilaginibacer rubeus --- Mucilaginibacter kameinonensis --- evolution --- CTnDOT --- Listeria monocytogenes --- cadmium --- arsenic --- gallium --- antimicrobial agents --- metal toxicity --- metal resistance --- metal-based antimicrobials --- platinum resistance --- RNA-Seq --- multireplicon --- Nanopore --- adaptive laboratory evolution --- n/a

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Anti-infective agents --- Drugs --- Anti-Infective Agents. --- Drug Prescriptions. --- Administration. --- Prescribing. --- Drug Prescribing --- Drug Prescription --- Drug Prescribings --- Prescribing, Drug --- Prescribings, Drug --- Legislation, Drug --- Pharmacy --- Anti-Microbial Agents --- Antiinfective Agents --- Antimicrobial Agents --- Anti-Infective Agent --- Anti-Microbial Agent --- Antimicrobial Agent --- Microbicide --- Microbicides --- Agent, Anti-Infective --- Agent, Anti-Microbial --- Agent, Antimicrobial --- Agents, Anti-Infective --- Agents, Anti-Microbial --- Agents, Antiinfective --- Agents, Antimicrobial --- Anti Infective Agent --- Anti Infective Agents --- Anti Microbial Agent --- Anti Microbial Agents --- Infections --- Parasites --- Drug prescribing --- Prescribing of drugs --- Prescription of drugs --- Chemotherapy --- Antiinfective agents --- Antimicrobial agents --- Antimicrobial drugs --- Antimicrobials --- Agents antiinfecciosos --- Administració de medicaments

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The alleged responsibility of meats and processed meat products for some of our population’s major health issues has created an opportunity for the promotion of meat analogs. This emerging competition forces the need for changes in livestock production systems for improving nutritive value and obtaining healthier and safer meat products. The morbidity and mortality attributed to Salmonella and other pathogens remain a public health issue. Hence, there is an urgent need for developing intervention technologies to control such pathogens. Beef is packaged with an array of healthy nutrients and is the highest valued livestock product. However, staples (e.g., pork, poultry) and some co-products can also be nutrient dense and/or provide a unique sensory experience with advantageous technological quality. Carcass yield is a major determinant of livestock value. Hence, objective technologies are strongly needed to effectively segregate the heterogeneous supply of carcasses into homogeneous groups in yield of cuts. Not all meats are created equal, and differences in their intrinsic characteristics may be expected when they are produced in different regions and under diverse production schemes. Nevertheless, reports aiming to characterize meats originated from different zones (e.g., tropical latitudes) are scarce. This Special Issue of Foods, “Progress on Nutrient Composition, Meat Standardization, Grading, Processing, and Safety for Different Types of Meat Sources”, comprising fourteen peer-reviewed papers, is now being released as a book that will serve as an invaluable reference in addressing the current dearth of knowledge regarding the aforementioned topics, and is also envisaged to serve in updating food scientists and stakeholders of the meat value chain globally.

chicken fat by-products --- unsaturated fatty acids --- colour properties --- lipid profile --- beef --- lamb --- pork --- trace elements --- micronutrients --- fatty acids --- genomics --- heritability --- Campylobacter jejuni --- antimicrobials --- decontamination --- poultry --- chicken wings --- application method --- indicator bacteria --- chlorine dioxide --- rhamnolipids --- 1,3-Dibromo-5.5-dimethyl hydantoin --- interventions --- barley --- corn --- blend --- eating quality --- volatile compounds --- Salmonella spp. --- E. coli --- pathogen surrogates --- ozone intervention --- beef trim --- tropical --- meat quality --- nutrient --- composition --- beef primals --- computer vision system --- dual energy X-ray absorptiometry --- mature cows --- rib-eye camera --- whole-side camera --- lactic acid --- UV-C --- Listeria monocytogenes --- LAB --- response surface methodology --- longissimus dorsii lumborum --- multivariate analyses --- proximate composition --- fatty acid profile --- mineral content --- carcass traits --- tropical beef cattle --- refrigerated meat shelf life --- microbial indicators --- vacuum packaging --- carcass chilling --- hot water intervention --- Salmonella --- chicken --- microbial intervention --- food-contact surfaces --- Pirenaica --- Protected Geographical Indication --- Ternera de Navarra --- Certified Angus Beef --- country of origin --- USDA standard --- sensory profile --- pig --- seaweed --- pork quality --- minerals --- proximal composition --- Macrocystis pyrifera --- n/a