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Biotechnology. --- Separation (Technology) --- Liquids. --- Fluids --- Permeability --- Polywater --- Analytical chemistry --- Chemistry, Technical --- Technology --- Chemical engineering --- Genetic engineering --- Chemical separations --- Separation processes --- Separation science --- Separation technologies --- Separations, Chemical

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This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs.

Medicine --- Pharmaceutical industries --- rebamipide --- nanocrystals --- oral mucositis --- hydrogel --- endocytosis --- enoxaparin --- lipid–polymer hybrid nanoparticles --- oral --- intestinal absorption --- naftidrofuryl oxalate --- solubility --- permeability --- dissolution profiles --- pharmaceutical availability --- BCS drug classification --- non-sink condition --- solubility–permeability interplay --- unstirred water layer --- poorly soluble drugs --- solubilizer additive --- phenylketonuria --- l-phenylalanine ammonia-lyase --- enzyme --- kinetics --- catabolism disorder --- biomedical drug --- P-glycoprotein --- breast cancer resistance protein --- LY335979 --- WK-X-34 --- in vivo–in vitro correlation --- lipolysis-permeation --- lipid-based drug delivery system --- PermeaPad --- cinnarizine --- lipolysis --- amorphous solid dispersion --- candesartan Cilexetil --- PVPK30 --- pH-modulation --- spray drying --- bioavailability --- nasal administration --- spray-drying --- chitosan --- microsphere --- meloxicam --- silymarin --- D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) --- liver distribution --- acetaminophen-induced hepatotoxicity --- extra virgin olive oil --- secoiridoids --- metabolism --- phenolic compounds --- intestinal permeability --- drug-phytochemical interaction --- hepatic metabolism --- mixed inhibition --- quercetin --- repaglinide --- rebamipide --- nanocrystals --- oral mucositis --- hydrogel --- endocytosis --- enoxaparin --- lipid–polymer hybrid nanoparticles --- oral --- intestinal absorption --- naftidrofuryl oxalate --- solubility --- permeability --- dissolution profiles --- pharmaceutical availability --- BCS drug classification --- non-sink condition --- solubility–permeability interplay --- unstirred water layer --- poorly soluble drugs --- solubilizer additive --- phenylketonuria --- l-phenylalanine ammonia-lyase --- enzyme --- kinetics --- catabolism disorder --- biomedical drug --- P-glycoprotein --- breast cancer resistance protein --- LY335979 --- WK-X-34 --- in vivo–in vitro correlation --- lipolysis-permeation --- lipid-based drug delivery system --- PermeaPad --- cinnarizine --- lipolysis --- amorphous solid dispersion --- candesartan Cilexetil --- PVPK30 --- pH-modulation --- spray drying --- bioavailability --- nasal administration --- spray-drying --- chitosan --- microsphere --- meloxicam --- silymarin --- D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) --- liver distribution --- acetaminophen-induced hepatotoxicity --- extra virgin olive oil --- secoiridoids --- metabolism --- phenolic compounds --- intestinal permeability --- drug-phytochemical interaction --- hepatic metabolism --- mixed inhibition --- quercetin --- repaglinide

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This book explores computational fluid dynamics applied to ship hydrodynamics and provides guidelines for the future developments in the field based on the Tokyo 2015 Workshop. It presents ship hull test cases, experimental data and submitted computational methods, conditions, grids and results. Analysis is made of errors for global (resistance, sinkage, trim and self-propulsion) and local flow (wave elevations, mean velocities and turbulence) variables, including standard deviations for global variables. The effects of grid size and turbulence models are evaluated for both global and local flow variables. Detailed analysis is made of turbulence modeling capabilities for capturing local flow physics. Errors and standard deviations are also assessed for added resistance (captive test cases) and course keeping/speed loss (free running test cases) in head and oblique waves. All submissions are used to evaluate the error and uncertainty by means of a systematic verification and validation (V&V) study along with statistical investigations.

Fluid mechanics. --- Fluids. --- Automotive engineering. --- Oceanography. --- Engineering Fluid Dynamics. --- Fluid- and Aerodynamics. --- Automotive Engineering. --- Hydraulics --- Mechanics --- Physics --- Hydrostatics --- Permeability --- Oceanography, Physical --- Oceanology --- Physical oceanography --- Thalassography --- Earth sciences --- Marine sciences --- Ocean --- Hydromechanics --- Continuum mechanics --- Ships --- Stability of ships --- Hydrodynamics --- Ships' stability --- Naval architecture

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This self-contained, interdisciplinary book encompasses mathematics, physics, computer programming, analytical solutions and numerical modelling, industrial computational fluid dynamics (CFD), academic benchmark problems and engineering applications in conjunction with the research field of anisotropic turbulence. It focuses on theoretical approaches, computational examples and numerical simulations to demonstrate the strength of a new hypothesis and anisotropic turbulence modelling approach for academic benchmark problems and industrially relevant engineering applications. This book contains MATLAB codes, and C programming language based User-Defined Function (UDF) codes which can be compiled in the ANSYS-FLUENT environment. The computer codes help to understand and use efficiently a new concept which can also be implemented in any other software packages. The simulation results are compared to classical analytical solutions and experimental data taken from the literature. A particular attention is paid to how to obtain accurate results within a reasonable computational time for wide range of benchmark problems. The provided examples and programming techniques help graduate and postgraduate students, engineers and researchers to further develop their technical skills and knowledge.

Fluid mechanics. --- Fluids. --- Computer simulation. --- Computer mathematics. --- Engineering Fluid Dynamics. --- Fluid- and Aerodynamics. --- Simulation and Modeling. --- Computational Science and Engineering. --- Computer mathematics --- Electronic data processing --- Mathematics --- Computer modeling --- Computer models --- Modeling, Computer --- Models, Computer --- Simulation, Computer --- Electromechanical analogies --- Mathematical models --- Simulation methods --- Model-integrated computing --- Hydraulics --- Mechanics --- Physics --- Hydrostatics --- Permeability --- Hydromechanics --- Continuum mechanics --- Turbulence --- Mathematical models. --- Flow, Turbulent --- Turbulent flow --- Fluid dynamics

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This book focuses on the mechanical properties and permeability of coal, and the gas flow in coal seams. Based on coal permeability models, it establishes different models for coal seam gas, from the linear flow model to the gas–solid coupling flow model. It also provides the theoretical basis for the exploitation and safe production of coal as well as coal seam gas resources. As such, it is a valuable reference for researchers, advanced students and practitioners working in mining engineering and coalbed methane engineering. .

Fossil fuels. --- Geotechnical engineering. --- Civil engineering. --- Natural disasters. --- Fossil Fuels (incl. Carbon Capture). --- Geotechnical Engineering & Applied Earth Sciences. --- Civil Engineering. --- Natural Hazards. --- Natural calamities --- Disasters --- Engineering --- Public works --- Engineering, Geotechnical --- Geotechnics --- Geotechnology --- Engineering geology --- Fossil energy --- Fuel --- Energy minerals --- Coal. --- Coal --- Mechanical properties. --- Permeability. --- Caustobioliths --- Fossil fuels