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This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process. Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well as translational and basic research scientists. Moreover, as one of the main clathrin-independent endocytic routes, compiling all the critical information about macropinocytosis in one collection, this book will also be helpful to educators and their students.
Cytology. --- Endocytosis. --- Absorption (Physiology) --- Cell physiology --- Cell biology --- Cellular biology --- Biology --- Cells --- Biophysics. --- Cell interaction. --- Biological transport. --- Cell membranes. --- Medicine --- Cell Biology. --- Mechanobiological Cell Signaling. --- Membrane Trafficking. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Health Workforce --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Membrane transport --- Passive transport, Biological --- Physiological transport --- Transport, Biological --- Diffusion --- Osmosis --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- Cellular control mechanisms --- Biological physics --- Medical sciences --- Physics
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Nano-engineering offers unique solutions for biomedical implants to meet compromised patient conditions via enhanced bioactivity and local drug release. This book presents the cutting-edge nano-engineered dental implant solutions that has the potential to ensure long-term success of dental implants while maintaining clinical translatability. From surface modification of titanium/zirconium dental implants to advanced therapeutic enhancements to treat infection and poor integration, this book advances the field of dental implant nano-engineering, showcasing current trends and future directions.
Technology: general issues --- History of engineering & technology --- endocytosis --- ipriflavone --- mesoporous nanospheres --- nanoparticles --- oxidative stress --- pre-osteoblasts --- implant --- nano-scaled surface --- blood clot --- LncRNA --- osseointegration --- bone regeneration --- zirconium --- zirconia --- dental implants --- nanopores --- electrochemical anodization --- extracellular vesicles --- exosomes --- nanomedicine --- regeneration --- cell-free therapy --- decontamination --- antibacterial agents --- nano-modified dental implant --- nanostructured titanium --- dental implant --- TiO2 nanotubes --- surface modification --- antibacterial --- titanium --- laser therapy --- peri-implantitis --- debridement --- implants --- nanostructure --- gingival fibroblasts --- biofilm --- soft-tissue integration --- n/a
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Nano-engineering offers unique solutions for biomedical implants to meet compromised patient conditions via enhanced bioactivity and local drug release. This book presents the cutting-edge nano-engineered dental implant solutions that has the potential to ensure long-term success of dental implants while maintaining clinical translatability. From surface modification of titanium/zirconium dental implants to advanced therapeutic enhancements to treat infection and poor integration, this book advances the field of dental implant nano-engineering, showcasing current trends and future directions.
Technology: general issues --- History of engineering & technology --- endocytosis --- ipriflavone --- mesoporous nanospheres --- nanoparticles --- oxidative stress --- pre-osteoblasts --- implant --- nano-scaled surface --- blood clot --- LncRNA --- osseointegration --- bone regeneration --- zirconium --- zirconia --- dental implants --- nanopores --- electrochemical anodization --- extracellular vesicles --- exosomes --- nanomedicine --- regeneration --- cell-free therapy --- decontamination --- antibacterial agents --- nano-modified dental implant --- nanostructured titanium --- dental implant --- TiO2 nanotubes --- surface modification --- antibacterial --- titanium --- laser therapy --- peri-implantitis --- debridement --- implants --- nanostructure --- gingival fibroblasts --- biofilm --- soft-tissue integration --- n/a
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Nano-engineering offers unique solutions for biomedical implants to meet compromised patient conditions via enhanced bioactivity and local drug release. This book presents the cutting-edge nano-engineered dental implant solutions that has the potential to ensure long-term success of dental implants while maintaining clinical translatability. From surface modification of titanium/zirconium dental implants to advanced therapeutic enhancements to treat infection and poor integration, this book advances the field of dental implant nano-engineering, showcasing current trends and future directions.
endocytosis --- ipriflavone --- mesoporous nanospheres --- nanoparticles --- oxidative stress --- pre-osteoblasts --- implant --- nano-scaled surface --- blood clot --- LncRNA --- osseointegration --- bone regeneration --- zirconium --- zirconia --- dental implants --- nanopores --- electrochemical anodization --- extracellular vesicles --- exosomes --- nanomedicine --- regeneration --- cell-free therapy --- decontamination --- antibacterial agents --- nano-modified dental implant --- nanostructured titanium --- dental implant --- TiO2 nanotubes --- surface modification --- antibacterial --- titanium --- laser therapy --- peri-implantitis --- debridement --- implants --- nanostructure --- gingival fibroblasts --- biofilm --- soft-tissue integration --- n/a
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The great success of nanotechnology promotes a tremendous revolution in the biomedical field. Functional nanomaterials have been widely applied for the treatment of various diseases, such as cancer, bacterial infection, diabetes, inflammation, and neurodegenerative disorders. Various therapeutic nanoplatforms have been developed with therapeutic functions and intelligent properties. However, the development of nanomedicine suffers from several challenges prior to their clinical applications. For instance, disease detection in an early stage is a critical challenge for nanomedicine. It is difficult to detect disease markers (e.g., proteins, genes, or cancer circulating cells), so nanoprobes with high sensitivity and selectivity are required. Moreover, to overcome drug resistance, it is highly desirable to develop functional nanomedicines with the combination of multiple therapeutic modalities, such as chemotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, radiotherapy, starving therapy, and immunotherapy. Additionally, the stability and degradability of most nanomedicines in biofluids should be carefully evaluated before their administration to humans. This book provides researchers with the latest investigations and findings in this field.
Medical equipment & techniques --- tumor microenvironment --- targeted therapy --- nanoparticles --- nano therapeutics --- tumor imaging --- cell membrane coated nanoparticle --- atherosclerosis --- thrombosis --- diagnosis and therapy --- cardiovascular disease --- Fe-based nanoparticles --- endosomal pH-responsive hyaluronate --- CD44 receptor-mediated endocytosis --- tumor therapy --- Alzheimer disease’s --- amyloid-β --- nanomaterials --- photothermal therapy --- photodynamic therapy --- biomedical imaging --- iodinated contrast media --- X-ray computed tomography --- organic nanoparticles --- iodinated polymers --- SARS-CoV-2 main protease --- colorimetry --- electrochemical impedance spectroscopy --- gold nanoparticles --- selenium --- selenium nanoparticles --- antioxidant activities --- clean-up procedure --- glutathione --- Parkinson’s disease --- L-DOPA --- curcumin --- nanozyme --- single-atom nanozyme --- surface modification --- ROS scavenging --- antibacterial --- electrostatic spinning --- inorganic nanocrystals --- polymer fibers --- antimicrobial --- biomedical --- graphene --- nanocomposites --- multimodal imaging --- phototherapy --- theranostics --- cancer --- bacterial infection --- n/a --- Alzheimer disease's --- Parkinson's disease
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Nephropathic cystinosis (MIM # 219800) is a rare autosomal recessive disorder caused by mutations in the lysosomal cystine transporter cystinosin, encoded by the CTNS gene (17p13.2). This devastating condition initially affects kidneys and subsequently many other organs including eyes, thyroid, pancreas, muscles, and brain. While lysosomal cystine storage is a key feature of the disease and the main target of current therapy, recent groundbreaking research has revealed that cystinosin has diverse functions in cells, being involved in vesicle trafficking, energy homeostasis, and cell death mechanisms. These discoveries deepen our insights into the mechanisms of cystinosis and of lysosomal biology in general. In this Special Issue dedicated to the pioneer of cystinosis research Dr. Jerry Schneider, we highlight the state-of-the-art understanding of cellular and molecular mechanisms of various disease features, opening new horizons for innovative treatment strategies for cystinosis and potentially other lysosomal storage diseases.
Medicine --- Pharmacology --- cystinosis --- cysteamine --- bone --- osteoclast --- genotype --- CD34+ hematopoietic stem and progenitor cells --- gene therapy --- pre-clinical studies --- investigational new drug application --- clinical trial --- disulfiram --- mice --- zebrafish --- fertility --- azoospermia --- hypogonadism --- histopathology --- mouse model --- lysosomal storage disease --- cell and animal models --- infantile nephropathic cystinosis --- bone-muscle wasting --- fibroblast growth factor 23 --- osteoclasts --- sclerostin --- leptin --- fractures --- nephropathic cystinosis --- hollow fiber membrane --- 3-dimensional models --- autophagy --- macrophages --- inflammasome --- proximal tubular cells --- endocytosis --- apoptosis --- chitotriosidase --- interleukins --- galectin-3 --- novel therapies --- endolysosome --- epithelial cell differentiation --- homeostasis --- lysosomal storage diseases --- mitochondrial distress --- kidney proximal tubule --- programmed cell death --- central nervous system --- cortical atrophy --- arterial spin labelling --- cystine blood level --- lysosomal storage disorder --- history --- treatment strategies for cystinosis --- newborn screening --- clinical course --- CTNS-pathogenic variants --- newborn screening for cystinosis --- kidney progenitors --- cell model --- biomarkers --- cystine --- kidney --- therapeutic monitoring
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Nephropathic cystinosis (MIM # 219800) is a rare autosomal recessive disorder caused by mutations in the lysosomal cystine transporter cystinosin, encoded by the CTNS gene (17p13.2). This devastating condition initially affects kidneys and subsequently many other organs including eyes, thyroid, pancreas, muscles, and brain. While lysosomal cystine storage is a key feature of the disease and the main target of current therapy, recent groundbreaking research has revealed that cystinosin has diverse functions in cells, being involved in vesicle trafficking, energy homeostasis, and cell death mechanisms. These discoveries deepen our insights into the mechanisms of cystinosis and of lysosomal biology in general. In this Special Issue dedicated to the pioneer of cystinosis research Dr. Jerry Schneider, we highlight the state-of-the-art understanding of cellular and molecular mechanisms of various disease features, opening new horizons for innovative treatment strategies for cystinosis and potentially other lysosomal storage diseases.
cystinosis --- cysteamine --- bone --- osteoclast --- genotype --- CD34+ hematopoietic stem and progenitor cells --- gene therapy --- pre-clinical studies --- investigational new drug application --- clinical trial --- disulfiram --- mice --- zebrafish --- fertility --- azoospermia --- hypogonadism --- histopathology --- mouse model --- lysosomal storage disease --- cell and animal models --- infantile nephropathic cystinosis --- bone-muscle wasting --- fibroblast growth factor 23 --- osteoclasts --- sclerostin --- leptin --- fractures --- nephropathic cystinosis --- hollow fiber membrane --- 3-dimensional models --- autophagy --- macrophages --- inflammasome --- proximal tubular cells --- endocytosis --- apoptosis --- chitotriosidase --- interleukins --- galectin-3 --- novel therapies --- endolysosome --- epithelial cell differentiation --- homeostasis --- lysosomal storage diseases --- mitochondrial distress --- kidney proximal tubule --- programmed cell death --- central nervous system --- cortical atrophy --- arterial spin labelling --- cystine blood level --- lysosomal storage disorder --- history --- treatment strategies for cystinosis --- newborn screening --- clinical course --- CTNS-pathogenic variants --- newborn screening for cystinosis --- kidney progenitors --- cell model --- biomarkers --- cystine --- kidney --- therapeutic monitoring
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The aim of this Special Issue is to collect reports regarding all the recent strategies, directed at the improvement of antineoplastic activity of drugs in cancer progression, engaging all the expertise needed for the development of new anticancer drugs: medicinal chemistry, pharmacology, molecular biology, and computational and drug delivery studies.
Research & information: general --- Biology, life sciences --- EGR-1 --- flavonoid --- (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile --- MDA-MB-231 --- MMP9 --- TNFα --- pancreatic ductal adenocarcinoma --- cyclodextrin inclusion complex --- phase solubility studies --- preformulation studies --- biphenylnicotinamide derivatives --- dual inhibitor --- EGFR --- VEGFR2 --- ligand-based pharmacophore --- molecular docking --- molecular dynamics --- leukemias --- doxorubicin --- inflammation --- drug delivery --- tumor targeting --- elastin-like polypeptide --- cell penetrating peptide --- matrix metalloproteinase --- doxorubicin resistance --- photosensitizer delivery system --- PAMAM dendrimer --- photodynamic therapy --- cytotoxicity --- phototoxicity --- colorectal adenocarcinoma --- dicarboximides --- chemical synthesis --- apoptosis --- kinases --- anticancer --- gene profiling --- SAR --- biomarkers --- colorectal cancer --- early detection examination --- liquid biopsy --- personalized medicine --- tumor treatment --- exosomes --- ctDNA --- CTC --- cytotoxic activity --- pyrazole derivatives --- MTT assay --- ADMET analysis --- single-crystal diffraction --- FTIR spectroscopy --- NMR spectroscopy thermogravimetric analysis --- acute myelogenous leukemia --- platelets --- microparticles --- γδ T cells --- immunotherapy --- tumor resistance --- combination therapy --- tumor microenvironment --- immune checkpoint inhibitor --- neuroblastoma --- molecular iodine --- cyclophosphamide --- xenografts --- metronomic therapy --- tamoxifen --- CYP2D6 --- MCF-7 --- Ishikawa cells --- SERM --- TNBC --- uterotrophic --- α-mangostin --- poly(amidoamine) dendrimer --- targeted drug delivery --- biotin targeting --- glioblastoma multiforme --- squamous cell carcinoma --- antiparasitic therapy --- diclofenac --- indomethacin --- oleanolic acid derivative conjugates --- NF-κB --- Nrf2 --- MAPKs --- PSN-1 cells --- reactive oxygen species --- glioblastoma --- brain tumor --- extracellular vesicles --- pancreatic cancer --- paclitaxel --- clathrin --- endocytosis --- sulforaphane --- nicotine --- metalloproteinase-9 --- gastric cancer --- cell invasion --- Arylquin 1 --- colon cancer --- tumor progression --- azelastine --- oxidative stress --- autophagy --- mitotic catastrophe --- chronic myeloid leukemia --- imatinib --- tyrosine kinase --- ketoconazole --- P-glycoprotein --- drug efflux transporter --- non-small-cell lung cancer --- cisplatin resistance --- aldehyde dehydrogenase --- isothiocyanates --- disulfiram --- epithelial to mesenchymal transition --- aminopeptidase N --- acetamidophenones --- Schiff bases --- semicarbazones --- thiosemicarbazones --- inhibition of proliferation
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This book includes some recent works providing the readers with novel relevant findings about the main signaling pathways that govern the molecular pathogenesis of some of the highest prevalent human tumors, which are the basis for developing alternative therapeutic strategies to improve patient outcomes.
Medicine --- Oncology --- actin cytoskeletal reorganization --- breast cancer --- CD99 agonist --- EGFR dimerization --- endocytosis --- FAK dephosphorylation --- PTPN12 --- Rac1 --- RhoA --- tripeptide --- OMD --- PRELP --- tumor suppression gene --- bladder cancer initiation --- tight junction --- partial EMT --- tousled-like kinase (TLK) --- NIMA-related kinase 1 (NEK1) --- yes-associated protein 1 (YAP1) --- thioridazine (THD) --- MS-determined phosphopeptides --- human immunodeficiency virus type 1 --- epithelial cells --- carcinogenicity --- oxidative stress --- reactive oxygen species --- gp120 --- Tat --- Nef --- matrix protein p17 --- reverse transcriptase --- mitochondria --- metastasis --- OXPHOS --- cancer --- Warburg effect --- cancer therapeutics --- myeloproliferative neoplasms --- signaling pathways --- JAK2 --- CALR --- MPL --- TPOR --- DUSP1 --- MAPK --- Snail --- prostate cancer --- migration and invasion --- patient survival --- biomarkers --- pBRD4 --- SET --- PP2A --- prognosis --- triple negative breast cancer --- resistance --- anti-receptor therapy --- trastuzumab --- PI3K --- mTOR --- TAK-228 --- epigenetic --- methylation --- acetylation --- non-coding RNA --- small-cell lung cancer --- triple-negative breast cancer --- pancreatic ductal adenocarcinoma --- glioblastoma --- metastatic melanoma --- advanced ovarian cancer --- hepatocellular carcinoma --- immune evasion --- immunotherapy --- immune checkpoint inhibitors --- oncogenic signaling pathway --- molecular targeted agents --- genome --- epigenome --- tumor immune microenvironment --- ovarian cancer --- adaptive immunity --- innate immunity --- complement system --- cancer immunology --- tumor microenvironment --- splicing pathway --- luminal breast cancer --- BET inhibitors --- n/a
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Long-term exposure to environmental toxicants is estimated to account for 70–90% of the risks of acquiring chronic ailments. Presently, chronic kidney disease and infertility affect a significant proportion of the world population, while research data indicate that exposure to toxic metals may contribute to the looming statistics. Alarming evidence suggests that exposure to the heavy metal cadmium may affect every stage of life, and exposure in early life may determine susceptibility to certain diseases in adulthood. Prevention of these outcomes requires avoidance of further environmental contamination, minimization of exposure, and reduction of toxic metals in food crops to the lowest achievable levels.
Public health & preventive medicine --- Trace elements --- hair --- children --- hazardous waste incinerator --- Constantí (Catalonia, Spain) --- blood lead level --- boatyard --- childhood --- lead poisoning --- fishing community --- lead weights --- β2-microglobulin --- cadmium --- creatinine clearance --- glomerular filtration --- N-acetyl-β-d-glucosaminidase --- nephron mass --- nephrotoxicity --- trace elements --- autopsy tissues --- temporal trends --- creatinine excretion --- glomerular filtration rate --- lead --- kidney --- endocytosis --- metallothionein --- flow cytometry --- proximal tubule epithelial cells --- OGTT --- minimal model --- glucose response mechanism --- genotoxicity --- aluminum chloride --- rats --- food --- farmer --- PTWI (provisional tolerable monthly intake) --- TWI (tolerable weekly intake) --- Monte Carlo simulation --- mercury --- obesogen --- lipid profiles --- hyperlipidemia --- elevated liver enzymes --- hexavalent chromium [Cr(VI)] --- mitochondrial fragmentation --- dynamin-related protein 1 (Drp1) --- mitochondrial respiratory chain complex I (MRCC I) --- reactive oxygen species (ROS) --- blood lead --- cellular immunity --- phagocytosis --- humoral munity --- immunosuppression --- insulin --- diabetes --- hyperglycemia --- hyperinsulinemia --- lipogenic --- β-cell toxicity --- stroke --- cerebrovascular accident --- heavy metal --- rare earth element --- case-control study --- mortality --- lifetime cadmium intake --- renal diseases --- urinary cadmium --- a follow-up study --- diet --- kidney function --- chronic kidney disease --- threshold limit --- tolerable intake level --- heavy metals --- birth weight --- preterm birth --- diet pattern --- Mediterranean diet --- pregnancy --- toxic metals --- reproduction --- testicular and ovarian structure --- n/a --- Constantí (Catalonia, Spain)
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