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Rabbit livestock is especially important in the Mediterranean area and in the semi-arid zones of Africa, Asia, and America, representing a valuable alternative source of good animal protein of high quality (low fat and low cholesterol). However, rabbit husbandry should adapt to be a competitive and sustainable sector. In addition, it must maintain a balance between rabbit welfare, customer demands, and breeder requirements. Then, improvement in breeding systems is needed and may involve avoiding hormones and antibiotics in rabbit management; enhancing the efficiency of reproductive procedures such as artificial insemination systems and freezing of semen and embryos; extending the productive lifespan of does; improving genetic selection systems; and adjusting nutritional systems to optimize the physiological status of animals and the immune response. This Special Issue concerns all these challenges in increasing rabbit productivity and sustainability.
Research & information: general --- Biology, life sciences --- Animals & society --- Oryctolagus cuniculus --- SNPs --- SLAF-seq --- genome-wide association study --- growth trait --- myeloperoxidase --- lysozyme --- rabbits --- viral infection --- rabbit hemorrhagic disease --- goji berries --- rabbit --- insulin resistance --- leptin --- non-esterified fatty acids --- pregnancy --- lactation --- body condition score --- principal component analysis --- gene expression --- endometrium --- oviduct --- spermatozoa --- seminal plasma --- inflammation --- angiogenesis --- corpus luteum --- reproduction --- genomic selection --- imputation --- litter size --- genomic simulation --- artificial insemination --- antibiotics --- antibacterial activity --- semen quality --- reproductive performance --- sperm quality --- cryopreservation --- animal model --- assisted reproductive technology --- CTSS --- granulosa cells --- proliferation --- apoptosis --- hormone secretion --- body composition --- fertility --- kits born alive --- rabbit does --- feed intake --- free tri-iodothyronine --- thyroxine --- insulin --- glucose --- corticosterone --- NEFA --- fetus --- placenta
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Rabbit livestock is especially important in the Mediterranean area and in the semi-arid zones of Africa, Asia, and America, representing a valuable alternative source of good animal protein of high quality (low fat and low cholesterol). However, rabbit husbandry should adapt to be a competitive and sustainable sector. In addition, it must maintain a balance between rabbit welfare, customer demands, and breeder requirements. Then, improvement in breeding systems is needed and may involve avoiding hormones and antibiotics in rabbit management; enhancing the efficiency of reproductive procedures such as artificial insemination systems and freezing of semen and embryos; extending the productive lifespan of does; improving genetic selection systems; and adjusting nutritional systems to optimize the physiological status of animals and the immune response. This Special Issue concerns all these challenges in increasing rabbit productivity and sustainability.
Oryctolagus cuniculus --- SNPs --- SLAF-seq --- genome-wide association study --- growth trait --- myeloperoxidase --- lysozyme --- rabbits --- viral infection --- rabbit hemorrhagic disease --- goji berries --- rabbit --- insulin resistance --- leptin --- non-esterified fatty acids --- pregnancy --- lactation --- body condition score --- principal component analysis --- gene expression --- endometrium --- oviduct --- spermatozoa --- seminal plasma --- inflammation --- angiogenesis --- corpus luteum --- reproduction --- genomic selection --- imputation --- litter size --- genomic simulation --- artificial insemination --- antibiotics --- antibacterial activity --- semen quality --- reproductive performance --- sperm quality --- cryopreservation --- animal model --- assisted reproductive technology --- CTSS --- granulosa cells --- proliferation --- apoptosis --- hormone secretion --- body composition --- fertility --- kits born alive --- rabbit does --- feed intake --- free tri-iodothyronine --- thyroxine --- insulin --- glucose --- corticosterone --- NEFA --- fetus --- placenta
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Rabbit livestock is especially important in the Mediterranean area and in the semi-arid zones of Africa, Asia, and America, representing a valuable alternative source of good animal protein of high quality (low fat and low cholesterol). However, rabbit husbandry should adapt to be a competitive and sustainable sector. In addition, it must maintain a balance between rabbit welfare, customer demands, and breeder requirements. Then, improvement in breeding systems is needed and may involve avoiding hormones and antibiotics in rabbit management; enhancing the efficiency of reproductive procedures such as artificial insemination systems and freezing of semen and embryos; extending the productive lifespan of does; improving genetic selection systems; and adjusting nutritional systems to optimize the physiological status of animals and the immune response. This Special Issue concerns all these challenges in increasing rabbit productivity and sustainability.
Research & information: general --- Biology, life sciences --- Animals & society --- Oryctolagus cuniculus --- SNPs --- SLAF-seq --- genome-wide association study --- growth trait --- myeloperoxidase --- lysozyme --- rabbits --- viral infection --- rabbit hemorrhagic disease --- goji berries --- rabbit --- insulin resistance --- leptin --- non-esterified fatty acids --- pregnancy --- lactation --- body condition score --- principal component analysis --- gene expression --- endometrium --- oviduct --- spermatozoa --- seminal plasma --- inflammation --- angiogenesis --- corpus luteum --- reproduction --- genomic selection --- imputation --- litter size --- genomic simulation --- artificial insemination --- antibiotics --- antibacterial activity --- semen quality --- reproductive performance --- sperm quality --- cryopreservation --- animal model --- assisted reproductive technology --- CTSS --- granulosa cells --- proliferation --- apoptosis --- hormone secretion --- body composition --- fertility --- kits born alive --- rabbit does --- feed intake --- free tri-iodothyronine --- thyroxine --- insulin --- glucose --- corticosterone --- NEFA --- fetus --- placenta --- Oryctolagus cuniculus --- SNPs --- SLAF-seq --- genome-wide association study --- growth trait --- myeloperoxidase --- lysozyme --- rabbits --- viral infection --- rabbit hemorrhagic disease --- goji berries --- rabbit --- insulin resistance --- leptin --- non-esterified fatty acids --- pregnancy --- lactation --- body condition score --- principal component analysis --- gene expression --- endometrium --- oviduct --- spermatozoa --- seminal plasma --- inflammation --- angiogenesis --- corpus luteum --- reproduction --- genomic selection --- imputation --- litter size --- genomic simulation --- artificial insemination --- antibiotics --- antibacterial activity --- semen quality --- reproductive performance --- sperm quality --- cryopreservation --- animal model --- assisted reproductive technology --- CTSS --- granulosa cells --- proliferation --- apoptosis --- hormone secretion --- body composition --- fertility --- kits born alive --- rabbit does --- feed intake --- free tri-iodothyronine --- thyroxine --- insulin --- glucose --- corticosterone --- NEFA --- fetus --- placenta
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In this Special Issue of Genes entitled “Genetic Conditions Affecting the Skeleton: Congenital, Idiopathic Scoliosis and Arthrogryposis”, evidence is presented that suggests that congenital, idiopathic scoliosis, and arthrogryposis share similar overlapping, but also distinct, etiopathogenic mechanisms, including connective tissue and neuromuscular mechanisms. Congenital scoliosis (CS) is defined by the presence of an abnormal spinal curvature, due to an underlying vertebral bony malformation (VM). Idiopathic scoliosis (IS) is defined by the presence of an abnormal structural spinal curvature of ≥10 degrees in the sagittal plane, in the absence of an underlying VM. Arthrogryposis is defined by the presence of congenital contractures in two or more joints of the appendicular skeleton. All three conditions have complex genetic causes. This Special Issue highlights the complex nature of these conditions and current concepts in our approach to better understand their genetics.
Research & information: general --- Biology, life sciences --- Genetics (non-medical) --- spinal curvatures --- scoliosis --- idiopathic --- DNA methylation --- pyrosequencing --- estrogen receptor 1 --- ESR1 --- scoliosis progression --- adolescent idiopathic scoliosis --- idiopathic scoliosis --- exome sequencing --- spine --- polygenic --- variants --- musculoskeletal disease --- cytoskeleton --- extracellular matrix --- contracture --- arthrogryposis --- congenital --- POC5 --- cilia --- genetics --- spine deformity --- genetic predisposition --- complex trait --- model animal --- genome wide association study --- genetic linkage study --- Amyoplasia --- DECIPHER (DatabasE of genomiC variation and Phenotype in Humans using Ensemble Resources) --- CNV (copy number variant) --- DA (distal arthrogryposis) --- IPA (ingenuity pathway analysis) --- HPO (human phenotype ontology) --- akinesia --- MYOD --- IGF2 --- FGFR1 (Fibroblast growth factor receptor 1) --- genetic variations --- congenital scoliosis --- monozygotic twin --- epigenome-wide association study --- bone --- discordant --- curve severity --- differentially methylated region --- congenital vertebral malformation --- copy number variant --- CNV --- CHRNG --- distal arthrogryposis type 8 --- Escobar --- multiple pterygium syndrome --- MYH3 --- protein tyrosine kinase 7 (PTK7) --- whole exome sequencing --- n/a
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