Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Structural engineering and architecture are both closely related to creative design. Both disciplines are diverse and different but there is a close interaction between the two as they both shape the primary elements composing a building. Reinforcing a transdiciplinary approach and emphasizing the overlap between structural engineering and architecture can significantly increase the quality of a project. Belgian engineers Ney & Partners have been fortunate to be entrusted with this role by their clients, architects and contractors who share the believe that buildings should only be designed through a collaborative process. Based on a selection of building projects, this book aims to illustrate what is possible whenan intensive dialogue between all the parties involved leads to an integrated design og building structures.

Architectural design --- Architecture --- Engineering design. --- Ney & Partners. --- Ney & Partners --- Structure métallique --- Structure en bois --- Structure légère --- Structure mixte --- Ingénierie

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This multidisciplinary collection investigates the ways in which marriage and partner migration processes have become the object of state scrutiny, and the site of sustained political interventions in several states around the world. Covering cases as varied as the United States, Canada, Japan, Iran, France, Belgium or the Netherlands, among others, contributors reveal how marriage and partner migration have become battlegrounds for political participation, control, and exclusion. Which forms of attachments (towards the family, the nation, or specific individuals) have become framed as risks to be managed? How do such preoccupations translate into policies? With what consequences for those affected by them, in terms of rights and access to citizenship? The book answers these questions by analyzing the interplay between issues of security, citizenship and rights from the perspectives of migrants and policymakers, but also from actors who negotiate encounters with the state, such as lawyers, non-governmental organizations, and translators.

Citizenship. --- Emigration and immigration --- Intercountry marriage. --- Transnationalism. --- Political aspects. --- partner migration, marriage, citizen, citizenship, security, rights, insecurity, wife, husband, financial concerns, partners, couples, migration studies, gender, gender studies, women, migration.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

La construction est aujourd'hui considérée comme l'activité humaine la plus consommatrice de ressources. Il est largement reconnu que le secteur doit subir un changement majeur, mais les voies possibles restent insaisissables. L'exposition What's Already There présente six projets conçus par des agences d'architecture basées à Bruxelles, qui témoignent d'un engagement fort en faveur d'une utilisation responsable des ressources locales - qu'il s'agisse d'énergie solaire, de matériaux géo et biosourcés, d'éléments de construction récupérés ou de structures existantes - ainsi que du dynamisme et des compétences des clients, des utilisateurs, des travailleurs ou des pairs intéressés. L'exposition est organisée comme une collection d'histoires sur des éléments architecturaux spécifiques. C'est à partir de ces fragments qu'émerge une image plus large de la multitude de défis auxquels nous devons faire face aujourd'hui. Que ce soit en tant qu'architectes, clients, entrepreneurs, législateurs ou utilisateurs, nous sommes tous des acteurs d'un secteur critique - et plus largement les habitants d'un monde que nous devons traiter avec plus d'attention..

Sustainable architecture --- Architecture durable --- Exhibitions. --- Expositions --- Karbon --- BC Architects and Studies (Firm) --- AgwA (Firm) --- OUEST architecture --- Rotor (Organization) --- Conix Architects (Firm) --- Ney & Partners --- Brussels (Belgium) --- Bruxelles (Belgique) --- Buildings, structures, etc. --- Environmental aspects --- Exhibitions. --- Constructions --- Aspect de l'environnement --- Expositions

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one hand, some of these transporters are involved in drug resistance (also referred to as MDR or multidrug resistance), a process known to be a major brake in most anticancer treatments, and the medical challenge is thus to specifically inhibit their function. On the other hand, molecular defects in some of these ABC transporters are correlated with several rare human diseases, the most well-documented of which being cystic fibrosis, which is caused by genetic variations in ABCC7/CFTR (cystic fibrosis transmembrane conductance regulator). In the latter case, the goal is to rescue the function of the deficient transporters using various means, such as targeted pharmacotherapies and cell or gene therapy. The aim of this Special Issue, “ABC Transporters in Human Diseases”, is to present, through original articles and reviews, the state-of-the-art of our current knowledge about the role of ABC transporters in human diseases and the proposed therapeutic options based on studies ranging from cell and animal models to patients.

Research & information: general --- Biology, life sciences --- ABC transporters --- drug action --- regulatory extension --- regulatory insertion --- mechanism of action --- MRP1 --- MRP4 --- breast cancer --- proliferation --- migration --- invasion --- cAMP --- ABCG2 --- ABCB1 --- blood-brain barrier --- PET --- Alzheimer’s disease --- beta-amyloid --- tariquidar --- erlotinib --- ABCG5 --- ABCG8 --- ATP-binding cassette transporter --- cholesterol --- polar relay --- sitosterolemia --- 5′ untranslated region --- cis-acting elements --- ABCA subfamily --- bioinformatics --- ABC transporter --- therapy response --- disease-free survival --- next-generation sequencing --- competitive allele-specific PCR --- P-glycoprotein --- amyloid-beta --- neuron --- SK-N-SH --- gene therapy --- AAV --- PFIC --- BSEP --- ABCB11 --- bile salts --- intrahepatic cholestasis --- chaperones --- PFIC2 --- BRIC --- ATP-binding cassette transporter A1 (ABCA1) --- cholesterol homeostasis --- reverse cholesterol transport --- HDL-C --- dyslipidemia --- type 2 diabetes --- microparticles --- ABCG2 genotype --- clinico-genetic analysis --- ethnic specificity --- genetic variations --- precision medicine --- rare variant --- Roma --- serum uric acid --- SUA-lowering therapy --- urate transporter --- bile secretion --- ABCB4 --- ABCC2 --- ABCG5/G8 --- molecular partners --- phytosterol --- xenosterol --- atherosclerosis --- gall stone --- ABC --- transporter --- ABC (ATP-binding cassette) transporters --- multidrug resistance --- transport --- trafficking --- urate --- mutations --- polymorphisms --- ABCC6 --- TNAP --- NT5E --- Pseudoxanthoma elasticum (PXE) --- cancer --- membrane protein --- functional divergence --- calcification --- pseudoxanthoma elasticum --- generalized arterial calcification of infancy --- pyrophosphate --- therapies --- ABCA7 --- phagocytosis --- Aβ peptides --- yeast --- multidrug transporter --- anticancer --- antifungal resistance --- mechanism --- peroxisome --- adrenoleukodystrophy --- fatty acids --- gout --- early-onset gout --- hyperuricemia --- uric acid --- BCRP --- single nucleotide polymorphism --- SNP --- homology modeling --- substrate-binding site --- cellular ATP efflux --- mutagenesis --- intracellular traffic --- MDR3 --- phosphatidylcholine --- RAB GTPase --- taxol --- drug transport --- n/a --- Alzheimer's disease --- 5' untranslated region

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Are 'Dear John' letters lethal weapons in the hands of men at war? Many US officers, servicemen, veterans, and civilians would say yes. Drawing on personal letters, oral histories, and psychiatric reports, as well as popular music and movies, Susan L. Carruthers shows how the armed forces and civilian society have attempted to weaponize romantic love in pursuit of martial ends, from World War II to today. Yet efforts to discipline feeling have frequently failed. And women have often borne the blame. This sweeping history of emotional life in wartime explores the interplay between letter-writing and storytelling, breakups and breakdowns, and between imploded intimacy and boosted camaraderie. Incorporating vivid personal experiences in lively and engaging prose - variously tragic, comic, and everything in between - this compelling study will change the way we think about wartime relationships.

Soldiers --- World War, 1939-1945 --- Man-woman relationships --- Military spouses --- Unmarried couples --- Rejection (Psychology) --- Social aspects --- Psychology. --- United States --- Armed Forces --- Military life. --- History, Military --- Miscellanea. --- Attitude (Psychology) --- Emotions --- Social isolation --- Cohabitation --- Domestic partners --- Living together --- Couples --- Common law marriage --- Free love --- Military wives --- Spouses --- Armed Forces personnel --- Members of the Armed Forces --- Military personnel --- Military service members --- Service members --- Servicemen, Military --- Female-male relationships --- Male-female relationships --- Men --- Men-women relationships --- Relationships, Man-woman --- Woman-man relationships --- Women --- Women-men relationships --- Interpersonal relations --- Mate selection --- Relations with women --- Relations with men --- ABŞ --- ABSh --- Ameerika Ühendriigid --- America (Republic) --- Amerika Birlăshmish Shtatlary --- Amerika Birlăşmi Ştatları --- Amerika Birlăşmiş Ştatları --- Amerika ka Kelenyalen Jamanaw --- Amerika Qūrama Shtattary --- Amerika Qŭshma Shtatlari --- Amerika Qushma Shtattary --- Amerika (Republic) --- Amerikai Egyesült Államok --- Amerikanʹ Veĭtʹsėndi︠a︡vks Shtattnė --- Amerikări Pĕrleshu̇llĕ Shtatsem --- Amerikas Forenede Stater --- Amerikayi Miatsʻyal Nahangner --- Ameriketako Estatu Batuak --- Amirika Carékat --- AQSh --- Ar. ha-B. --- Arhab --- Artsot ha-Berit --- Artzois Ha'bris --- Bí-kok --- Ē.P.A. --- EE.UU. --- Egyesült Államok --- ĒPA --- Estados Unidos --- Estados Unidos da América do Norte --- Estados Unidos de América --- Estaos Xuníos --- Estaos Xuníos d'América --- Estatos Unitos --- Estatos Unitos d'America --- Estats Units d'Amèrica --- Ètats-Unis d'Amèrica --- États-Unis d'Amérique --- Fareyniḳṭe Shṭaṭn --- Feriene Steaten --- Feriene Steaten fan Amearika --- Forente stater --- FS --- Hēnomenai Politeiai Amerikēs --- Hēnōmenes Politeies tēs Amerikēs --- Hiwsisayin Amerikayi Miatsʻeal Tērutʻiwnkʻ --- Istadus Unidus --- Jungtinės Amerikos valstybės --- Mei guo --- Mei-kuo --- Meiguo --- Mî-koet --- Miatsʻyal Nahangner --- Miguk --- Na Stàitean Aonaichte --- NSA --- S.U.A. --- SAD --- Saharat ʻAmērikā --- SASht --- Severo-Amerikanskie Shtaty --- Severo-Amerikanskie Soedinennye Shtaty --- Si︠e︡vero-Amerikanskīe Soedinennye Shtaty --- Sjedinjene Američke Države --- Soedinennye Shtaty Ameriki --- Soedinennye Shtaty Severnoĭ Ameriki --- Soedinennye Shtaty Si︠e︡vernoĭ Ameriki --- Spojené obce severoamerické --- Spojené staty americké --- SShA --- Stadoù-Unanet Amerika --- Stáit Aontaithe Mheiriceá --- Stany Zjednoczone --- Stati Uniti --- Stati Uniti d'America --- Stâts Unîts --- Stâts Unîts di Americhe --- Steatyn Unnaneysit --- Steatyn Unnaneysit America --- SUA (Stati Uniti d'America) --- Sŭedineni amerikanski shtati --- Sŭedinenite shtati --- Tetã peteĩ reko Amérikagua --- U.S. --- U.S.A. --- United States of America --- Unol Daleithiau --- Unol Daleithiau America --- Unuiĝintaj Ŝtatoj de Ameriko --- US --- USA --- Usono --- Vaeinigte Staatn --- Vaeinigte Staatn vo Amerika --- Vereinigte Staaten --- Vereinigte Staaten von Amerika --- Verenigde State van Amerika --- Verenigde Staten --- VS --- VSA --- Wááshindoon Bikéyah Ałhidadiidzooígíí --- Wilāyāt al-Muttaḥidah --- Wilāyāt al-Muttaḥidah al-Amirīkīyah --- Wilāyāt al-Muttaḥidah al-Amrīkīyah --- Yhdysvallat --- Yunaeted Stet --- Yunaeted Stet blong Amerika --- ZDA --- Združene države Amerike --- Zʹi︠e︡dnani Derz︠h︡avy Ameryky --- Zjadnośone staty Ameriki --- Zluchanyi︠a︡ Shtaty Ameryki --- Zlucheni Derz︠h︡avy --- ZSA --- Η.Π.Α. --- Ηνωμένες Πολιτείες της Αμερικής --- Америка (Republic) --- Американь Вейтьсэндявкс Штаттнэ --- Америкӑри Пӗрлешӳллӗ Штатсем --- САЩ --- Съединените щати --- Злучаныя Штаты Амерыкі --- ولايات المتحدة --- ولايات المتّحدة الأمريكيّة --- ولايات المتحدة الامريكية --- 미국 --- États-Unis --- É.-U. --- ÉU