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Biochemistry 10e with Achieve builds on over four decades of exceptional writing, clear graphics, coverage of the latest research technique, and its signature emphasis on physiological and medical relevance with new emphasis on the importance of diversity and team work and a focus on problem-solving techniques and skills. With a new and updated suite of online resources, including hundreds of end-of-chapter problems with answer-specific feedback, activities for in-class and out-of-class, and an emphasis on visualization, Biochemistry with Achieve sets a new standard for biochemistry programs !

Biochemistry. --- Molecular biology. --- Biochimie. --- Biologie moléculaire. --- Study and teaching (higher)

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"Even the most experienced instructor can find teaching cell biology daunting, and most cell biology texts are bogged down in detail or background information. Lost in all the details are the more fascinating material and contemporary advances that represent this rapidly moving field. With so much to cover, creating a classroom around active learning may be difficult or nearly impossible. The Cell: A Molecular Approach, Ninth Edition, endeavors to address those issues with succinct writing, incorporation of current research, a test bank that encourages critical thinking, and an active learning framework. With just enough detail for a one-semester, sophomore/junior level course, the text presents fundamental concepts and current research, including chapters on Genomics and Transcriptional Regulation and Epigenetics, and in-text boxed features on Molecular Medicine, Key Experiments, and Interactive Data Analysis Problems. Finally, for instructors who want to flip their classrooms or just get students more engaged, The Cell, Ninth Edition, is the only cell biology text that is accompanied by an Active Learning Guide. This chapter-by-chapter playbook shows instructors how to create a dynamic learning environment with in-class exercises, clicker questions, and links to relevant media, animations, testing, and self-quizzing, all aligned with the new in-text learning objectives, wherever appropriate. This text provides the right level of detail, student engagement, and instructor support for the modern cell biology classroom"--

Cells. --- Cell Biology. --- Cell Physiological Phenomena. --- Molecular Biology. --- Cytologie. --- Cellules. --- Biologie cellulaire. --- Biologie moléculaire.

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Background: The meniscal tear is one of the most common injuries in the knee joint. In recent years, as more important to the function of the meniscus has been attached, the traditional meniscectomy has been gradually replaced by repair techniques. Regenerative medicine research in meniscus has become the current mainstream trend, but due to the heterogeneity within the meniscus, the natural healing processes are very complicated.&#13;Objective: To describe macroscopical and histological changes of the meniscus at different time points after meniscectomy.&#13;Methods: 6 young sheep and 6 old sheep were enrolled to access the effect of age on the microstructure of the meniscus. 16 sheep performed medial partial meniscectomy and anterior cruciate ligament transection (pMMx+ACLT) surgery and 4 sheep performed SHAM operation were enrolled in the study. The histological staining was visualized using a modified Pauli’s histological tissue quality score system to evaluate histological changes of the left and right medial and lateral meniscus at weeks 4, 6, and 28.&#13;Results: Young sheep had higher cellularity and quality score than old sheep (p<0.01). At weeks 4 and 6, the healed part of the left medial meniscus (LMMx) had a lower score than the remaining part (LMM) and lateral meniscus (p<0.01). At week 28, LMMx had no significant difference compared with LMM.&#13;Conclusion: After the medial partial meniscectomy and anterior cruciate ligament transection surgery, the meniscus will regenerate through fibroblasts and collagen fibers, but it cannot restore to the state before the injury. It will also cause degeneration of the ipsilateral meniscus. The findings will be helpful to meniscal regenerative treatment strategies.

Meniscal healing --- partial meniscectomy --- meniscal repair --- regenerative medicine --- histological staining --- Sciences du vivant > Biochimie, biophysique & biologie moléculaire

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Fully-automated sample-to-answer biochemical assays are needed in intensive care units, e.g., for the real-time monitoring of antibiotic concentration in blood samples from patients whose physiological state may quickly vary. The Lab-on-Disk developed in the Medicare project offers a promising integrated solution to this request. A Lab-on-Disk is a centrifugal microfluidic platform that consists in a rotating disk that contains microchambers and microchannels. The liquids flow therein thanks to centrifugal forces and can be mixed together to perform the assays. For the robustness of the assays, liquids have to be regulated by valves. In particular, the passive capillary valve is the simplest to implement as it only consists in an abrupt enlargement of the channel geometry.&#13;&#13;This master's thesis aims at identifying the bursting conditions of a given valve and at characterizing the emptying dynamics of the reservoir upstream once the valve opens. Thanks to a first set of experiments, which consisted in performing a ramp on the angular frequency, we could identify the bursting pressure of a given valve. In a second set, we performed a pulse on the frequency to trigger the valve, followed by a steady frequency plateau during which the reservoir chamber emptied. The properties of the fluid interfaces were measured by computer vision. High-resolution videos of the experiments were processed by the Medicare HUB software developed as part of the master's thesis.&#13;&#13;Considering the bursting conditions, the Laplace pressure of the interface in the reservoir chamber is shown to add a significant contribution to the pressure balance. The bursting pressures can be expressed as a Laplace law that involves a geometrical parameter independent of the angular acceleration in the range [0, 1000 RPM]. The main source of uncertainty is identified as the time discretization due to the video recording. Then, considering the emptying dynamics, the flow in the waste chamber is characterized by a Bond number greater than or close to unity. Five emptying scenarios are characterized on the basis of the outlet jet behaviour and a phase diagram is presented to discriminate between them. Lastly, an analytical model is presented to reproduce the experimental observations and its limitation are discussed thanks to the phase diagram.

Lab-on-Disk --- LoD --- Microfluidics --- Centrifugal --- Valve --- Capillary --- Passive --- Ingénierie, informatique & technologie > Ingénierie chimique --- Ingénierie, informatique & technologie > Multidisciplinaire, généralités & autres --- Sciences de la santé humaine > Multidisciplinaire, généralités & autres --- Sciences du vivant > Biochimie, biophysique & biologie moléculaire --- Sciences du vivant > Multidisciplinaire, généralités & autres --- Physique, chimie, mathématiques & sciences de la terre > Chimie --- Physique, chimie, mathématiques & sciences de la terre > Physique --- Physique, chimie, mathématiques & sciences de la terre > Multidisciplinaire, général & autres