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The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics. This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to improve diagnostics, prognostics, and genomic surveillance, and to facilitate development of effective treatments and vaccines. Chapters are written by an international team of experts and explore methods in the areas of genomics, transcriptomics, proteomics, and metabolomics. Techniques used to assess physiological function at the molecular level and artificial intelligence approaches used for more effective validation and translation of biomarker candidates into clinical use are also discussed. This book is an excellent resource for researchers studying biomarkers, virology, metabolic diseases, and infectious diseases, as well as clinical scientists, physicians, drug company scientists, and healthcare workers.

Biochemical markers. --- Proteins. --- Metabolism. --- Genomics. --- Biomarkers. --- Genome research --- Genomes --- Molecular genetics --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- Indicators (Biology) --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Research

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This handbook of the series Biomarkers in Disease informs comprehensively about all aspects of monitoring and detecting toxicity in the human body and model organisms. Biomarkers for assessing toxicity in diverse organs are presented and different assays and methods are explained. Single compounds and drugs and their toxicity for humans are shown and the methods for detection described. Similar to all the volumes of the Biomarkers in Disease series, the chapters are written by experts in their field, each chapter features key facts summarizing the most important aspects of its respective topic and the definitions of words and terms facilitate the reading and understanding. This handbook is a must-have for researchers in toxicology and biomedicine who analyze the effects of drugs and various other substances in the human body and in model organisms. It also serves as a thorough guide for clinicians and pharmacologists.

Biochemical markers. --- Toxicology. --- Medicine—Research. --- Biology—Research. --- Pharmacology. --- Forensic sciences. --- Biomarkers. --- Medical Toxicology. --- Biomedical Research. --- Forensic Science. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- Biochemistry --- Indicators (Biology) --- Criminalistics --- Forensic science --- Science --- Criminal investigation --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Toxicology --- Physiological effect

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The welfare of an individual could be severely affected by stressful events. Mainly for this reason, the scientific community is interested in finding specific and quantifiable characteristics which could indicate or predict specific signs of acute or chronic stress exposure. The aim of this reprint is to reflect this interest in the field of companion animal physiology. The authors engaged in publishing this reprint are experts in the multiple mechanisms involved in stress response, including the detection of behavioral and physical signs which can be measured through biological indicators of homeostasis displacement. The editors strongly believe this topic will be of interest not only to researchers in this field, but also to dog trainers, dog shelter workers and veterinary behaviorists.

Dogs --- Biochemical markers. --- Stress (Physiology) --- Social aspects. --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- Biochemistry --- Indicators (Biology) --- Canis canis --- Canis domesticus --- Canis familiarus --- Canis familiarus domesticus --- Canis lupus familiaris --- Dog --- Domestic dog --- Domestic animals --- Gray wolf --- Physiological stress --- Tension (Physiology) --- Adaptation (Biology)

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This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their detection by biomarkers. Biomarkers and methods used in critical care and critically ill patients are discussed, as well as biomarkers in trauma and special conditions. Specific biomarker components are explained and models for modeling trauma in research are presented. This systematic handbook is an excellent resource for researchers and specialists in trauma research and treatment, as well as clinicians and physicians who want a thorough overview of various injuries, trauma, and their detection methods.

Biochemical markers. --- Cytology. --- Stress (Physiology). --- Cardiovascular system. --- Physiology. --- Cardiology. --- Neurology. --- Diagnosis. --- Biomarkers. --- Cellular Stress. --- Cardiovascular Physiology. --- Diseases --- Examinations, Medical (Diagnosis) --- Medical diagnosis --- Medical examinations (Diagnosis) --- Medical tests (Diagnosis) --- Clinical medicine --- Prognosis --- Symptoms --- Medicine --- Nervous system --- Neuropsychiatry --- Heart --- Internal medicine --- Animal physiology --- Animals --- Biology --- Anatomy --- Circulatory system --- Vascular system --- Blood --- Physiological stress --- Tension (Physiology) --- Adaptation (Biology) --- Cell biology --- Cellular biology --- Cells --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- Biochemistry --- Indicators (Biology) --- Diagnosis --- Testing --- Physiology --- Circulation --- Life sciences. --- Biosciences --- Sciences, Life --- Science

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This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.

Precision Medicine. --- Pharmacogenetics. --- Pharmacogenomic Variants. --- MicroRNAs --- RNA, Long Noncoding. --- Biomarkers. --- Neoplasms --- Medical Oncology. --- therapy. --- Clinical Oncology --- Oncology, Medical --- Oncology, Clinical --- Biochemical Marker --- Biologic Marker --- Biologic Markers --- Clinical Marker --- Immune Marker --- Immune Markers --- Immunologic Marker --- Laboratory Marker --- Marker, Biochemical --- Marker, Biological --- Marker, Clinical --- Marker, Immunologic --- Marker, Laboratory --- Marker, Serum --- Marker, Surrogate --- Serum Marker --- Surrogate End Point --- Surrogate End Points --- Surrogate Endpoint --- Surrogate Endpoints --- Surrogate Marker --- Viral Marker --- Biochemical Markers --- Biological Markers --- Biomarker --- Clinical Markers --- Immunologic Markers --- Laboratory Markers --- Markers, Biochemical --- Markers, Biological --- Markers, Clinical --- Markers, Immunologic --- Markers, Laboratory --- Markers, Serum --- Markers, Surrogate --- Markers, Viral --- Serum Markers --- Surrogate Markers --- Viral Markers --- Biological Marker --- End Point, Surrogate --- End Points, Surrogate --- Endpoint, Surrogate --- Endpoints, Surrogate --- Marker, Biologic --- Marker, Immune --- Marker, Viral --- Markers, Biologic --- Markers, Immune --- Molecular Probes --- Endophenotypes --- LINC RNA --- LincRNAs --- Long Intergenic Non-Protein Coding RNA --- Long Non-Coding RNA --- Long Non-Protein-Coding RNA --- Long Noncoding RNA --- Long ncRNA --- Long ncRNAs --- RNA, Long Non-Translated --- lncRNA --- LincRNA --- RNA, Long Untranslated --- Long Intergenic Non Protein Coding RNA --- Long Non Coding RNA --- Long Non Protein Coding RNA --- Long Non-Translated RNA --- Long Untranslated RNA --- Non-Coding RNA, Long --- Non-Protein-Coding RNA, Long --- Non-Translated RNA, Long --- Noncoding RNA, Long --- RNA, Long Non Translated --- RNA, Long Non-Coding --- RNA, Long Non-Protein-Coding --- Untranslated RNA, Long --- ncRNA, Long --- ncRNAs, Long --- Micro RNA --- MicroRNA --- Primary MicroRNA --- Primary miRNA --- miRNAs --- pre-miRNA --- pri-miRNA --- RNA, Small Temporal --- Small Temporal RNA --- miRNA --- stRNA --- MicroRNA, Primary --- RNA, Micro --- Temporal RNA, Small --- miRNA, Primary --- pre miRNA --- pri miRNA --- RNA, Small Interfering --- Pharmacogenetic Variants --- Pharmacokinetic Genetic Variants --- Genetic Variant, Pharmacokinetic --- Genetic Variants, Pharmacokinetic --- Pharmacogenetic Variant --- Pharmacogenomic Variant --- Pharmacokinetic Genetic Variant --- Variant, Pharmacogenetic --- Variant, Pharmacogenomic --- Variants, Pharmacogenetic --- Variants, Pharmacogenomic --- Pharmacogenetics --- Precision Medicine --- P Health --- P-Health --- Personalized Medicine --- Theranostics --- Individualized Medicine --- Predictive Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- Medicine, Predictive --- Theranostic --- Pharmacogenomic Variants --- Patient-Specific Modeling --- Pharmacogenomics --- Drug Resistance --- Toxicology --- Cancer. --- Cancer—Genetic aspects. --- Oncology. --- Therapeutics. --- Cancer Biology. --- Cancer Genetics and Genomics. --- Medical treatment --- Therapy --- Treatment of diseases --- Treatments for diseases --- Clinical medicine --- Tumors --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors