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This thought-provoking book covers the full range of psychopharmacologic practice in textbook fashion, offering a fresh and comprehensive self-examination. Unlike conventional texts of psychopharmacology, this text speaks directly to clinicians who have started to question the limitations of psychopharmacologic claims and the rigid confines of DSM-5 diagnoses. Drawing from their clinical and research experience as well as new literature, the well-published authors provide a new perspective that encourages readers to reevaluate established practices and embrace that medication is just one component of treatment and has limits. The book could be used by psychiatric residents in their course of study, by clinical psychology students taking a psychopharmacology course, or by psychiatrists curious to get a readable but comprehensive look at new critical viewpoints in psychopharmacology that have changed since they were taught. Many neuroscience students who are looking for a review of clinical effects to guide their basic research may also find the proposed text more useful than those texts that collate clinical trials. Current texts are for specialized scientists or are part of multi-authored texts which list drugs alphabetically with no conceptual framework, or books that pretend that each biochemical drug property has a clear and known clinical result presented in cartoon style. Some lesser known texts for psychology or nursing students are not authoritative. Others aimed at patients or families are too simplistic for clinicians. The authors’ goal was to create a unified text expressing their view of psychopharmacology, its evidence base, the unity of its essential principles, and its independence of DSM or ICD diagnosis. Several new history books describe the "rise and fall" of psychopharmacology, the corruption of big pharma and the failure of large controlled clinical trials. Psychopharmacology Reconsidered: A Concise Guide Exploring the Limits of Diagnosis and Treatment ensures that young clinicians are aware of and understand this critical zeitgeist but aware also of the essential core of psychopharmacology and the evidence upon which it rests.

Psychiatry. --- Neurology. --- Neuropharmacology. --- Nervous system --- Diagnosis. --- Therapeutics. --- Neurological Disorders. --- Diseases.

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The field of muscular dystrophies has expanded significantly with the discovery of the genetic defects and protein products underlying these disorders. New treatments such as antisense oligonucleotides and siRNAs and gene therapies are now in clinical application and in trials. As clinical trials increase, outcome measurement becomes very important, and more validated tools are being developed. This book provides a comprehensive review of these disorders. Clinical features, diagnostic testing including genetic testing of these disorders, the basis and utility of genetic testing, and the basis of genetic therapies are all covered in detail. This book will provide neuromuscular neurologists, general neurologists, and neuromuscular fellows with a much needed update in the field.

Neurology. --- Diagnosis. --- Therapeutics. --- Nervous system --- Neurological Disorders. --- Diseases. --- Muscular dystrophy.

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This volume explores the latest techniques used to study the human brain towards understanding Alzheimer’s Disease and related neurodegenerative disorders. Contributed to by world-renowned experts, the chapters in this book are divided into five parts. Part One discusses human post-mortem brain preparations including single-cell isolation and use of specialized imaging. Part Two talks about neural cellular models using primary and human induced pluripotent stem cells to model aspects of the human brain. Part Three details nucleic acid analyses including transcriptomic and somatic genomic changes, and Part Four discusses lipid analyses via mass spectrometry. Lastly, Part Five covers protein analyses, particularly Aβ and Tau. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Alzheimer’s Disease: Methods and Protocols is a valuable tool for all researchers who want to expand their knowledge and understanding of this disease and other related dementias.

Neurosciences. --- Nervous system—Diseases. --- Neurophysiology. --- Neurons. --- Neuroscience. --- Neurological Disorders. --- Cellular Neuroscience.

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This thought-provoking book covers the full range of psychopharmacologic practice in textbook fashion, offering a fresh and comprehensive self-examination. Unlike conventional texts of psychopharmacology, this text speaks directly to clinicians who have started to question the limitations of psychopharmacologic claims and the rigid confines of DSM-5 diagnoses. Drawing from their clinical and research experience as well as new literature, the well-published authors provide a new perspective that encourages readers to reevaluate established practices and embrace that medication is just one component of treatment and has limits. The book could be used by psychiatric residents in their course of study, by clinical psychology students taking a psychopharmacology course, or by psychiatrists curious to get a readable but comprehensive look at new critical viewpoints in psychopharmacology that have changed since they were taught. Many neuroscience students who are looking for a review of clinical effects to guide their basic research may also find the proposed text more useful than those texts that collate clinical trials. Current texts are for specialized scientists or are part of multi-authored texts which list drugs alphabetically with no conceptual framework, or books that pretend that each biochemical drug property has a clear and known clinical result presented in cartoon style. Some lesser known texts for psychology or nursing students are not authoritative. Others aimed at patients or families are too simplistic for clinicians. The authors’ goal was to create a unified text expressing their view of psychopharmacology, its evidence base, the unity of its essential principles, and its independence of DSM or ICD diagnosis. Several new history books describe the "rise and fall" of psychopharmacology, the corruption of big pharma and the failure of large controlled clinical trials. Psychopharmacology Reconsidered: A Concise Guide Exploring the Limits of Diagnosis and Treatment ensures that young clinicians are aware of and understand this critical zeitgeist but aware also of the essential core of psychopharmacology and the evidence upon which it rests.

Psychopharmacology. --- Psychiatry. --- Neurology. --- Neuropharmacology. --- Nervous system --- Diagnosis. --- Therapeutics. --- Neurological Disorders. --- Diseases.

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This authoritative and updated Atlas provides a comprehensive span of topics across all of sleep medicine, including old to futuristic approaches. It captures the significant changes and advances in the field and a wealth of new visual information available since the last edition. Edited and contributed by leaders in the art and science of sleep medicine, the Atlas highlights how the field of sleep medicine is truly a mix of several medical specialties. The field continues to rapidly evolve with research leading to some future directions. This Atlas remains a standard reference for Sleep Physicians, including Sleep Fellows and other trainees in Sleep Medicine, Sleep Technologists, and Sleep researchers.

Neurology. --- Respiratory organs --- Psychiatry. --- Nervous system --- Otorhinolaryngology. --- Cardiology. --- Pneumology. --- Neurological Disorders. --- Diseases.