Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This collection of epilepsy surgical cases illustrates patients with straightforward and challenging pharmacoresistant epilepsy. These cases convey the advancements, investigative strategies, past and modern surgical tools, and sophisticated state-of-the-art of epilepsy surgery and its disciplines. This textbook is organized into four major sections that parallel the contemporary FDA-approved and clinically applicable approaches: resective surgery, disconnection procedures, laser therapy, and neuromodulation. The chapters provide a case-based, interactive, and multidisciplinary integrative approach to pre-operative evaluation, data analysis, and surgical decision-making. In addition, we present alternative approaches to certain diagnostic tools, decision-making strategies, and surgical interventions. This textbook will provide trainees and clinicians with an exhaustive understanding of epilepsy surgery. Moreover, it will be an invaluable resource for preparation for the epilepsy board examination.

Neurology. --- Medical sciences. --- Pediatrics. --- Health Sciences. --- Epilepsy --- Surgery.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Even though life expectancy increased in the last decades, ageing has been considered a strong risk factor for age-related diseases, disability and death. The further understanding of cellular and molecular aspects of ageing could predict the onset of diseases in advance, prevent functional decline and identify targets for interventions focused in healthy ageing. The hypothesis that organismal ageing and dysfunction is influenced by the accumulation of senescent cells had origin in Hayflick and Moorhead results from cultured human fibroblasts. It was shown that fibroblasts presented a limited capacity for proliferation reaching thus the state of irreversible growth arrest (replicative senescence). In 2011, van Deusen et al. showed that p16Ink4a accumulation was associated with premature ageing in a mouse model and the inactivation of the p16Ink4a gene mitigated the ageing phenotype. Thus, the cell cycle arrest due to the expression of p16Ink4a and p21CIP (cell cycle inhibitors) is the main characteristic of senescence. In addition to cellular senescence, the hallmarks of ageing include genomic instability, telomere shortening , epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, stem cell exhaustion, altered intercellular communication, and a pro-inflammatory senescence-associated secretory phenotype (SASP). In this book, researchers will comprehensively discuss relevant changes occurring at cellular and molecular levels (human and animal models) based on the hallmarks of ageing. The impact of lifestyle and benefits of physical activity and nutrition will be also discussed. Unravelling cellular and molecular aspects of ageing is crucial for the unanswered questions about ageing and for guiding interventions such as changes in lifestyle, senolytic (kills senescent cells), and senomorphic (interrupts deleterious intercellular communication) therapies.

Molecular biology. --- Cytology. --- Genetics. --- Immunology. --- Medical sciences. --- Molecular Biology. --- Cell Biology. --- Genetics and Genomics. --- Health Sciences.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This unique medical guide focuses on scars. The impact of scars is often underestimated and rarely discussed, and they are considered an inevitable side effect of surgery or trauma. Although therapies for distressing scars do exist, many are based on myths rather than evidence. This strongly practice-oriented book provides step-by-step instructions with scales and measuring instruments for assessing scars. Featuring brief abstracts and summaries, this valuable reference resource benefits clinical professionals such as doctors and nurses alike. It will appeal to practitioners who want to understand the nature and background of planned treatments, and to non-experts who simply want to broaden their medical horizons.

Surgery, Plastic. --- Dermatology. --- Surgery. --- Medical sciences. --- Pediatrics. --- Psychology. --- Plastic Surgery. --- Health Sciences. --- Behavioral Sciences and Psychology. --- Hypertrophic scars. --- Scars.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The British Journal of Radiology is a multidisciplinary journal covering all clinical and technical aspects of diagnostic imaging, radiotherapy and oncology, medical physics and radiobiology. The multidisciplinary approach of the journal enables readers to keep up-to-date with developments in their own as well as related fields.

Physical methods for diagnosis --- Radiology. --- Radiology --- X-rays --- Radiologie --- Rayons X --- Periodicals. --- Périodiques --- X-rays. --- #TS:WDEP --- Periodicals --- Health Sciences --- Diagnostics --- Oncology --- Biophysics --- Radiation --- Life Sciences --- Physics --- General and Others --- Radiologic and Imaging Nursing --- Health Sciences. --- Radiation. --- Life Sciences. --- Physics. --- Rays, Roentgen --- Roentgen rays --- Roentgenograms --- Electromagnetic waves --- Ionizing radiation --- Cathode rays --- Radiography --- Vacuum-tubes --- Radiological physics --- Journal