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As part of its core mission, the U.S. Environmental Protection Agency (EPA) is tasked with assessing the hazards and risks to human health from exposure to pollutants. While some pollutants are well studied, there are little or no data on the potential health effects for many thousands of chemicals that can make their way into the environment, such as PFAS. EPA still relies on laboratory mammalian studies as the foundation of most human health risk assessments, which are limited by high costs, long timelines, and other concerns. New approach methods (NAMs) in toxicology, for example new in vivo and in vitro strategies and computational systems biology, offer opportunities to inform timely decision-making when no data are available from laboratory mammalian toxicity tests or epidemiological studies. NAMs may also help inform efforts to protect susceptible and vulnerable populations by characterizing subtle health perturbations, better encompassing genetic diversity, and accounting for nonchemical stressors. While the promise and need for NAMs is clear, many barriers to their use remain. This report aims to bridge the gap between the potential of NAMs and their practical application in human health risk assessment. Building Confidence in New Evidence Streams for Human Health Risk Assessment draws lessons learned from laboratory mammalian toxicity tests to help inform approaches for building scientific confidence in NAMs and for incorporating such data into risk assessment and decision-making. Overall, the report recommendations aim to ensure a seamless handoff from the evaluation of NAM-based testing strategies in the laboratory to the incorporation of NAM data into modern, systematic-review-based risk assessments.
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This is the long-awaited pocket text on risk assessment for students and professionals in all health and safety fields. Risk assessment and risk-based decision-making are essential skills in today’s health and safety fields, but a convenient pocket or desk reference has been needed with enough theory to begin a preliminary risk assessment, together with clear explanations, applications, and worked examples. This book addresses that need. It provides a practical resource for estimating risks in various applications, as well as assisting with the design of larger project-based assessments. It explains the two main numeric procedures: probabilistic, or “catastrophic”, and quantitative, or “chronic”, risk assessment, along with chapters on qualitative risk assessment and approaches to food-related risks. A final chapter examines how people perceive risk, and provides advice and assistance in the development of essential, effective risk communication with the public and with the media. Numerous case studies are analyzed. Assessment and Communication of Risk: A Pocket Text for Health and Safety Professionals is a one-stop resource for students in all health and safety fields, and provides a valuable guide for existing field practitioners in public health, occupational health and safety, hospitals, environmental assessment offices, and ministries of health, labour, and the environment.
Public health. --- Occupational health services. --- Communication in science. --- Communication in medicine. --- Environmental health. --- Public Health. --- Occupational Health. --- Science Communication. --- Health Communication. --- Environmental Health. --- Environmental quality --- Health --- Health ecology --- Public health --- Environmental engineering --- Health risk assessment --- Health communication --- Medical communication --- Medicine --- Communication in research --- Science communication --- Science information --- Scientific communications --- Science --- Employee health services --- Medical care --- Medicine, Industrial --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation --- Health aspects --- Environmental aspects --- Industrial safety.
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