TY - BOOK ID - 125083070 TI - AMP-Activated Protein Kinase Signalling AU - Neumann, Dietbert AU - Viollet, Benoit PY - 2019 PB - MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - n/a KW - HDACs KW - transcription KW - epigenetics KW - spermatozoa KW - par complex KW - A769662 KW - MDCK KW - skeletal muscle KW - AID KW - phosphorylation KW - energy metabolism KW - monocytes KW - autophagy KW - CML KW - liver KW - hindlimb suspension KW - pregnancy KW - preeclampsia KW - gestational diabetes mellitus KW - CaMKK2 KW - assisted reproduction techniques KW - nutrient-sensing signals KW - sonic hedgehog KW - protein acetylation KW - glycogen storage disease KW - AMPK KW - adenosine monophosphate-activated protein kinase KW - AICAR KW - indirect calorimetry KW - IL-1? KW - MyHC I(?) KW - HDAC4/5 KW - endothelial cells KW - infection KW - hepatocyte KW - p70S6K KW - lipid metabolism KW - host defense KW - exercise KW - kidney disease KW - heat shock protein KW - ?RIM KW - mycobacteria KW - activation loop KW - developmental origins of health and disease (DOHaD) KW - CREB KW - TAK1 KW - metabolic-inflammation KW - phenylephrine KW - AMP-activated protein kinase (AMPK) KW - KATs KW - 2-methoxyestradiol KW - DNA methylation KW - NLRP3 KW - pump KW - ?-linker KW - steatosis KW - AMPK kinase KW - stress KW - endothelial nitric-oxide synthase KW - vasodilation KW - adherent junctions KW - epithelial cells KW - glycogen KW - Akt KW - synaptic activation KW - cellular energy sensing KW - glucose uptake KW - transporter KW - co-expression KW - atrophy KW - nutrigenomics KW - motility KW - vasoconstriction KW - fatty acid oxidation KW - oxidative stress KW - AS160 KW - membrane KW - histone modification KW - sirtuin 1 (SIRT1) KW - chromatin remodeling KW - insulin signalling KW - dietary fatty acids KW - ULK KW - CMML KW - adaptive thermogenesis KW - mTOR KW - MDS KW - mechanical unloading KW - AML KW - endothelial function KW - medulloblastoma KW - PKA KW - adipose tissue KW - NAD
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KW - membranes KW - nutrition KW - ZO-1 KW - TBC1D4 KW - adipocyte KW - soluble Adenylyl cyclase KW - metabolism KW - renin-angiotensin system KW - energy utilization KW - proteasome KW - differentiation KW - signaling KW - peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) KW - hypertrophy KW - AMP-activated protein kinase KW - metabolic disease KW - LKB1 KW - soleus muscle KW - macrophages KW - Immediate early genes KW - CBS KW - beiging KW - motor endplate remodeling KW - ionomycin KW - nectin-afadin KW - tight junctions KW - resveratrol KW - protein kinase B KW - regrowth KW - mitochondria KW - protein synthesis KW - energy deficiency KW - catechol-
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-methyltransferase KW - fiber-type KW - microarrays KW - carrier KW - acetyl-CoA KW - hypertension KW - 3T3-L1 KW - hypothalamus KW - food intake KW - benign UR - https://www.unicat.be/uniCat?func=search&query=sysid:125083070 AB - Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included. ER -