ID - 131770937 TI - The combinatorial index PY - 1998 SN - 9780121413408 0121413403 9780080542409 0080542409 1281025860 9781281025869 9786611025861 6611025863 PB - San Diego : ©1998 Academic Press, DB - UniCat KW - Combinatorial chemistry KW - Pharmaceutical chemistry. UR - https://www.unicat.be/uniCat?func=search&query=sysid:131770937 AB - With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest, "which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. Key Features * Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods * Serves as a laboratory manual for bench chemists * Includes a chapter on linkers to assist in choice of linking strategy * Discusses strengths and limitations of the various methods * Contains a structural index showing functional group transformations in solid-phase synthesis. ER -