TY - BOOK ID - 133769260 TI - Genome Mining and Synthetic Biology in Marine Natural Products Discovery PY - 2021 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Technology: general issues KW - genome mining KW - global regulator KW - LaeA KW - overexpression KW - Penicillium dipodomyis KW - sorbicillinoids KW - ulvan-derived oligosaccharides KW - ulvan lyase KW - heterologous expression KW - polysaccharide lyase family 25 KW - whole-genome sequencing KW - docosahexaenoic acid (DHA) KW - polyunsaturated fatty acid KW - fatty acid synthesis pathway KW - polyketide synthase pathway KW - bacteria KW - fungi KW - natural products KW - synthetic biology KW - microalgae KW - monogalactosyldiacylglycerol synthase KW - UDP-sulfoquinovose synthase KW - sulfoquinovosyltransferase KW - monogalactosyldiacylglycerols KW - sulfoquinovosyldiacylglycerols KW - transcriptome analysis KW - n/a UR - https://www.unicat.be/uniCat?func=search&query=sysid:133769260 AB - In recent years, marine genomics has become a growning rapidly field, helped by the large amount of information that is becoming available to the international scientific community. Taking into account the current excitement in the field of marine biotechnology, this Special Issue entitled “Genome Mining and Synthetic Biology in Marine Natural Product Discovery” aims to to assess the impact of these molecular approaches on the discovery of bioactive compounds from marine organisms. The term “genome mining” is used to identify all bioinformatic investigations aimed at detecting the biosynthetic pathways of bioactive natural products and their possible functional and chemical interactions. Several studies are now reporting on marine organisms. Oceans cover nearly 70% of the Earth’s surface and host a huge ecological, chemical, and biological diversity. The natural conditions of the sea favor, in marine organisms, the production of a large variety of novel molecules with great pharmaceutical potential. Marine organisms are unique in their structural and functional features compared to terrestrial ones. Innovation in this field is very rapid, as revealed by the funding of several Seventh Framework Programme (FP7) and Horizon 2020 projects under the topic “Blue Growth”, with the urgent goal of discovering new drugs. ER -