TY - BOOK ID - 135514858 TI - Colorectal Cancers: From Present Problems to Future Solutions PY - 2022 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Phage KW - bacteriophages KW - diet KW - infection KW - colorectal KW - cancer KW - nutrition KW - circulating tumor cells KW - colorectal cancer KW - EPISPOT assay KW - CellSearch® system KW - predictive value KW - chromatin density KW - nanoscale KW - tumour cell heterogeneity KW - microRNAs KW - metastasis KW - super-resolution microscopy KW - early onset KW - cohort KW - epidemiology KW - liquid biopsy KW - biomarker KW - indirect carcinogenesis KW - bovine meat and milk factors (BMMF) KW - chronic zoonosis KW - multiplex KW - tumor immunology KW - immune landscape KW - spontaneous feline intestinal tumors KW - comparative oncology KW - tumor budding KW - CTNNB1 KW - genome-wide methylation array KW - methylation KW - miRNA KW - colon cancer KW - personalized treatment KW - drug combinations KW - Matrix Metalloproteinases (MMPs) KW - polyp KW - TIMPs KW - MMP polymorphisms KW - MMP targeting KW - S100A4 KW - DKK1 KW - Wnt signaling KW - patient survival KW - gender KW - rectal cancer KW - radiochemotherapy KW - radiosensitivity KW - DNA double-strand breaks KW - deposited energy KW - quality of life KW - blood values KW - (molecular) carcinogenesis KW - cancer progression KW - (single) cancer cell heterogeneity KW - models KW - infectious agents KW - (targeted) therapy KW - personalized medicine UR - https://www.unicat.be/uniCat?func=search&query=sysid:135514858 AB - The scientific community has made significant progress in our molecular understanding of sporadic and hereditary colorectal carcinogenesis and progression. Thie pertains to, e.g., the discovery of (mutated) oncogenes and tumor suppressor genes, microsatellite instabilities, modifications in DNA repair, cellular aging, signaling cascades, genomic, epigenetic, transcriptional, translational, and protein modifications, as well as microbiotic factors and further parameters. Progression and metastasis have been more intensively studied, especially during recent years, leading to an intensified knowledge on molecular protagonists and microenvironmental interactions contributing to invasion, dissemination, and metastasis; still, more concerted efforts need to be made to better understand issues such as metastasis to different sites or the metastatic heterogeneity of single cells. Nevertheless, based on actual discoveries, personalized medicine, together with highly interdisciplinary therapeutic strategies combining advanced levels of surgical techniques, oncology, and radiation in neoadjuvant, adjuvant, or palliative settings, has started to improve the clinical prognosis of individual patients with colorectal cancer. The present Special Issue features articles of excellent international experts with the latest data in the fields mentioned. With this Special Issue, we aim to deepen discussions amongst colleagues in all kinds of disciplines working on this disease and to intensify interdisciplinary collaborations aimed at an ultimate understanding of strategies to defeat and prevent, colorectal cancer, and its progression. ER -