TY - BOOK ID - 2618977 TI - Genetic instability and tumorigenesis PY - 1997 VL - 221 SN - 0070217X SN - 3540615180 9783540615187 3642644341 3642605052 PB - Berlin : Springer, DB - UniCat KW - Cancer--Pathogenesis KW - Carcinogenese KW - Carcinogenesis KW - Carcinogénèse KW - Congenital diseases KW - Disorders [Genetic ] KW - Disorders [Inherited ] KW - Désordres génétiques KW - Genetic diseases KW - Genetic disorders KW - Genetische stoornissen KW - Hereditary diseases KW - Inherited diseases KW - Kanker--Ontstaan KW - Oncogenesis KW - Pathogenesis of cancer KW - Stoornissen [Genetische ] KW - Troubles génétiques KW - Tumorigenesis KW - Tumors KW - DNA repair. KW - Neoplasms KW - DNA Damage. KW - DNA Repair. KW - Mutagenesis. KW - Genetic aspects. KW - Genetics. KW - Etiology. KW - Dna damage KW - DNA repair KW - genetics KW - Dna damage. KW - genetics. KW - etiology. KW - Cancer research. KW - Cell biology. KW - Biochemistry. KW - Environmental health. KW - Cancer Research. KW - Cell Biology. KW - Biochemistry, general. KW - Environmental Health. KW - Environmental quality KW - Health KW - Health ecology KW - Public health KW - Environmental engineering KW - Health risk assessment KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Biology KW - Chemistry KW - Medical sciences KW - Cell biology KW - Cellular biology KW - Cells KW - Cancer research KW - Health aspects KW - Environmental aspects KW - Composition KW - Deoxyribonucleic acid repair KW - Repair, DNA KW - Repair mechanisms in DNA KW - Biochemical genetics KW - Antimutagens KW - Cancer KW - Pathology KW - Genetic toxicology KW - Pathogenesis UR - https://www.unicat.be/uniCat?func=search&query=sysid:2618977 AB - M. B. KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe notypic changes in somatic cells. Usually, when we think about genetic diseases, we think about inheriting one or two abnormal genes from our parents and these gene abnormalities confer the disease phenotype. In contrast, in the majority of cancers, no such inherited gene abnormalities can be identified (which does not mean that they do not exist) and there is no obvious family history suggesting an inherited disease. The vast majority of genes which are altered in the cancer cells are not transmitted through the germ line, but rather become abnormal in somatic cells sometime during the lifetime of the individual. Thus, the critical question which arises is "how do these genetic changes occur in somatic cells?". Epidemiologic data suggest that exposure to environmental carcinogens con tributes to the genesis of at least 80% of all human cancers (DOLL and PETO 1981). Thus, it is natural to suspect that the genetic changes in somatic cells which con tribute to the transformed phenotype arise from DNA damage caused by such exposures. Therefore, understanding how cells respond to DNA-damaging agents is likely to be an important component of our understanding of the genesis of human tumors. ER -