TY - BOOK ID - 4869050 TI - Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP) AU - Fonta, Caroline. AU - Négyessy, László. PY - 2015 SN - 9789401771979 9401771960 9789401771962 9401771979 PB - Dordrecht : Springer Netherlands : Imprint: Springer, DB - UniCat KW - Biomedicine. KW - Human Physiology. KW - Animal Physiology. KW - Developmental Biology. KW - Neurosciences. KW - Medicine. KW - Human physiology. KW - Developmental biology. KW - Médecine KW - Physiologie humaine KW - Neurosciences KW - Biologie du développement KW - Alkaline phosphatase. KW - Phosphatases. KW - Human Anatomy & Physiology KW - Health & Biological Sciences KW - Physiology KW - Phosphoesterases KW - Phosphohydrolases KW - Animal physiology. KW - Phosphatases KW - Zinc enzymes KW - Esterases KW - Development (Biology) KW - Biology KW - Growth KW - Ontogeny KW - Animal physiology KW - Animals KW - Anatomy KW - Human biology KW - Medical sciences KW - Human body KW - Neural sciences KW - Neurological sciences KW - Neuroscience KW - Nervous system UR - https://www.unicat.be/uniCat?func=search&query=sysid:4869050 AB - Phosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. The proposed book aims to provide an overview of our current understanding of the functions of TNAP in the brain. ER -