TY - BOOK ID - 75217261 TI - Role of lipids in virus assembly AU - Jamil S Saad AU - Saad, Jamil S. AU - Muriaux, Delphine M. PY - 2015 SN - 9782889195824 PB - Frontiers Media SA DB - UniCat KW - RNA viruses. KW - Lipids KW - Microbiology. KW - Lipides KW - Lipins KW - Lipoids KW - Biomolecules KW - Steroids KW - Riboviruses KW - Viruses, RNA KW - Viruses KW - Microbial biology KW - Biology KW - Microorganisms KW - NMR KW - Matrix KW - membrane KW - Gag KW - Ebola KW - VP40 KW - retroviruses KW - HIV 1 UR - https://www.unicat.be/uniCat?func=search&query=sysid:75217261 AB - RNA enveloped viruses comprise several families belonging to plus and minus strand RNA viruses, such as retroviruses, flavoviruses and orthomyxoviruses. Viruses utilize cellular lipids during critical steps of replication like entry, assembly and egress. Growing evidence indicate important roles for lipids and lipid nanodomains in virus assembly. This special topic covers key aspects of virus-membrane interactions during assembly and egress, especially those of retroviruses and Ebola virus (EBOV). Virus assembly and release involve specific and nonspecific interactions between viral proteins and membrane compartments. Retroviral Gag proteins assemble predominantly on the PM. Despite the great progress in identifying the factors that modulate retroviral Gag assembly on the PM, there are still gaps in our understanding of precise mechanisms of Gag-membrane interactions. Studies over the last two decades have focused on the mechanisms by which other retroviral Gag proteins interact with membranes during assembly. These include human immunodeficiency virus (HIV), Rous sarcoma virus (RSV), equine infectious anemia virus (EIAV), Mason-Pfizer monkey virus (M-PMV), murine leukemia virus (MLV), and human T-lymphotropic virus type (HTLV-1). Additionally, assembly of filoviruses such as EBOV also occurs on the inner leaflet of the PM. The articles published under this special topic highlight the latest understanding of the role of membrane lipids during virus assembly, egress and release. ER -