TY - BOOK ID - 5512600 TI - Ex vivo cell therapy AU - Nordon, Robert AU - Schindhelm, Klaus PY - 1999 SN - 9780126249606 0126249601 9780080531335 0080531334 PB - [Place of publication not identified] Academic Press DB - UniCat KW - Hematopoietic Stem Cell Transplantation. KW - Gene therapy. KW - Immunotherapy. KW - Cellular therapy. KW - Hematopoietic stem cells KW - Thérapie cellulaire KW - Cellules souches hématopoïétiques KW - Transplantation. KW - Transplantation KW - Stem Cell Transplantation KW - Hematopoietic Stem Cell Transplantation KW - Cell Transplantation KW - Surgical Procedures, Operative KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Health & Biological Sciences KW - Pharmacy, Therapeutics, & Pharmacology KW - Ghost Surgery KW - Operative Procedures KW - Operative Surgical Procedure KW - Operative Surgical Procedures KW - Procedure, Operative Surgical KW - Procedures, Operative Surgical KW - Surgery, Ghost KW - Surgical Procedure, Operative KW - Operative Procedure KW - Procedure, Operative KW - Procedures, Operative KW - General Surgery KW - Transplantations KW - Transplantation Immunology KW - Transplantation Conditioning KW - Transplantation, Cell KW - Cells KW - Transplantation, Hematopoietic Stem Cell KW - Stem Cell Transplantation, Hematopoietic KW - Hematopoietic Stem Cells KW - Bone Marrow Transplantation KW - Bone Marrow Purging KW - Hematopoietic Stem Cell Mobilization KW - Transplantation, Stem Cell KW - Stem Cell Transplantations KW - Transplantations, Stem Cell KW - Stem Cells KW - transplantation KW - Surgical Procedures KW - Procedure, Surgical KW - Procedures, Surgical KW - Surgical Procedure UR - http://www.unicat.be/uniCat?func=search&query=sysid:5512600 AB - Over the last two decades advances in the understanding of disease at a cellular and molecular level has led to innovative therapies that are based on the administration of cells which have been modified outside of the body. Ex vivo cell therapy is in essence gene therapy delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, or other conditions such as cancer or genetic diseases. These manipulations include the purification and culture of therapeutic cell subtypes, as well as elimination of cells which cause disease (cancer cells or immune cells reacting to the body itself). Gene therapy can be delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, cancer or genetic diseases. For small-scale laboratory methods to become clinically applicable processes, these new therapies require efficient technologies for cell separation, cell production in culture and gene transfer. This book integrates the recent advances in biological and clinical research with developments in cell-based technologies to provide a comprehensive review for clinicians, researchers, biotechnologists and biomedical engineers working in this rapidly developing area. The biotechnology and pharmaceutical industry requires a broad perspective for development of future technologies, and this text will provide then with an excellent overview of this rapidly evolving field. Key Features * Comprehensive review by leading researchers * Hematopoietic stem cell development: transcriptional control, signaling pathways, hematopoietic growth factors and adhesion molecules * Clinical developments: hematopoietic stem cell transplantation, cellular immunotherapy and gene therapy * Enabling technologies: cell separation, bioreactors, and gene transfer regulatory issues. ER -