TY - BOOK ID - 125098629 TI - Paternal influences on human reproductive success PY - 2013 SN - 1107357578 1107236142 1107341701 1107349036 1107347955 1139169343 1107345456 1299403387 1107344204 PB - Cambridge : Cambridge University Press, DB - UniCat KW - Infertility, Male KW - Social aspects. UR - https://www.unicat.be/uniCat?func=search&query=sysid:125098629 AB - Historically, sperm have been seen as simply a mechanism of transferring a haploid set of chromosomes to the oocyte. However, data from assisted reproduction therapies (ART) have demonstrated that in many couples the sperm appears to be responsible for abnormal embryogenesis. Recent advances in genetic and epigenetic techniques have identified key mechanisms by which the sperm, and the DNA carried by the sperm, can affect early embryonic development. Paternal Influences on Human Reproductive Success examines the genetic and epigenetic influences on embryogenesis, as well as practical clinical factors related to the male contribution to reproductive success. It also provides 'cutting edge' data and analysis of recent evaluations of the role of advanced paternal age, environmental influences and lifestyle factors on male reproductive fitness, making this an invaluable text for physicians treating patients for infertility, recurrent pregnancy loss, and developmental anomalies, as well as basic scientists studying embryogenesis and spermatogenesis. ER -