TY - BOOK ID - 126294671 TI - Hedgehog Signaling in Organogenesis and Tumor Microenvironment PY - 2020 PB - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - Cyp26 enzymes KW - congenital anomalies KW - CRE/LoxP KW - hedgehog signaling KW - mouse models KW - retinoic acid KW - smoothened KW - sonic hedgehog KW - sonic hedgehog (SHH) KW - oral squamous cell carcinoma (OSCC) KW - tumor microenvironment (TME) KW - tumor-associated macrophages (TAMs) KW - cancer-associated fibroblasts (CAFs) KW - tumor-associated angiogenesis KW - hedgehog KW - growth plate KW - endochondral ossification KW - chondrocyte KW - osteoblast KW - bone disease KW - TMJ KW - synovial joint KW - articular disc KW - Ihh KW - PTHrP KW - osteoarthritis KW - epithelial–mesenchymal interaction (EMI) KW - prostate cancer KW - external genitalia KW - androgen KW - basement membrane KW - bone morphogenetic protein KW - stem cell KW - animal experiment KW - fracture healing KW - cancer stem cells KW - hypospadias KW - urethra KW - penis KW - bone KW - hedgehog signalling KW - tooth development KW - epithelial and mesenchymal interaction KW - Gli1 KW - mesenchymal stem cell KW - lineage tracing analysis KW - stem cell marker KW - n/a KW - epithelial-mesenchymal interaction (EMI) UR - https://www.unicat.be/uniCat?func=search&query=sysid:126294671 AB - The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, multiple cancers’ drug resistance, and survival rates. This book focuses on several aspects of Hedgehog signaling in organogenesis and the tumor microenvironment, and presents reviews and original papers on recent efforts in the field of Hedgehog signaling. ER -