TY - BOOK ID - 216409 TI - The cancer degradome : proteases and cancer biology PY - 2008 SN - 128179189X 9786611791896 0387690573 0387690565 PB - New York : Springer, DB - UniCat KW - Cancer KW - Proteolytic enzymes. KW - Molecular aspects. KW - Peptide hydrolases KW - Proteases KW - Hydrolases KW - Oncology. KW - Human genetics. KW - Microbiology. KW - Immunology. KW - Medical virology. KW - Medicine. KW - Cancer Research. KW - Human Genetics. KW - Medical Microbiology. KW - Virology. KW - Molecular Medicine. KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Medical microbiology KW - Virology KW - Virus diseases KW - Immunobiology KW - Serology KW - Microbial biology KW - Biology KW - Microorganisms KW - Genetics KW - Heredity, Human KW - Physical anthropology KW - Tumors KW - Health Workforce KW - Cancer research. KW - Medical microbiology. KW - Molecular biology. KW - Microbiology KW - Cancer research KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Biomolecules KW - Systems biology UR - https://www.unicat.be/uniCat?func=search&query=sysid:216409 AB - Proteases that act in the extracellular environment have been historically associated with tumorigenesis and metastasis by virtue of their ability to carry out "path-clearing" for cancer cells. In the past few years it has become clear that they also shape the pericellular signaling environment, with profound consequences for cell fate and phenotype in both normal development and disease states. The repertoire of proteases that cells and tissues coordinately regulate in order to modulate their local environment is the DEGRADOME – which in humans is represented by at least 569 proteases in five catalytic classes. "The Cancer Degradome: Proteases in Cancer Biology" , edited by Dylan Edwards, Francesco Blasi, Gunilla-Høyer-Hansen and Bonnie Sloane, covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how protease activity can be imaged both in vitro and in vivo; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; the links that have emerged between proteolysis and cell signaling; how the Degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to target proteolysis for therapy. ER -