TY - BOOK ID - 2671182 TI - Specificity, function, and development of NK cells : NK cells: the effector arm of innate immunity AU - Kärre, Klas AU - Colonna, Marco PY - 1998 VL - 230 SN - 3540639411 3642468616 3642468594 PB - Berlin : Springer, DB - UniCat KW - Cells [Killer ] KW - Cellules K KW - Cellules immunocompetentes KW - Immunocompetent cells KW - Immunocompetente cellen KW - Immunologically competent cells KW - K cellen KW - K cells KW - Killer cells KW - NK cells KW - Natural killer cells KW - Immunology. KW - Cancer research. KW - Hematology. KW - Cancer Research. KW - Haematology KW - Internal medicine KW - Blood KW - Cancer research KW - Immunobiology KW - Life sciences KW - Serology KW - Diseases UR - https://www.unicat.be/uniCat?func=search&query=sysid:2671182 AB - Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recognition events lead to intracellular signals which can be either stimulatory or inhibitory. This book provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells, and into their biological role in controlling infections and tumors. ER -