TY - BOOK ID - 8654893 TI - Telomeres and Telomerase in Cancer PY - 2009 SN - 1282047922 9786612047923 1603278796 1603273069 1617378887 PB - Totowa, NJ : Humana Press : Imprint: Humana, DB - UniCat KW - Antineoplastic agents KW - Cancer KW - Cell transformation, Neoplastic. KW - Neoplasms KW - Telomerase. KW - Telomere KW - Telomerase KW - Cell Transformation, Neoplastic KW - Telomere-Binding Proteins KW - Antineoplastic Agents KW - Genetics KW - Drug Therapy KW - Ribonucleoproteins KW - Neoplastic Processes KW - Therapeutic Uses KW - Diseases KW - Therapeutics KW - Chromosome Structures KW - Biology KW - DNA-Binding Proteins KW - Chromosomal Proteins, Non-Histone KW - RNA-Directed DNA Polymerase KW - Nuclear Proteins KW - DNA-Directed DNA Polymerase KW - Pathologic Processes KW - RNA-Binding Proteins KW - Proteins KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Pharmacologic Actions KW - Biological Science Disciplines KW - Genetic Structures KW - Chromosomes KW - Natural Science Disciplines KW - Pathological Conditions, Signs and Symptoms KW - Amino Acids, Peptides, and Proteins KW - Nucleoproteins KW - DNA Nucleotidyltransferases KW - Genetic Phenomena KW - Intranuclear Space KW - Carrier Proteins KW - Chemical Actions and Uses KW - Chemicals and Drugs KW - Cell Nucleus Structures KW - Nucleotidyltransferases KW - Disciplines and Occupations KW - Phenomena and Processes KW - Cell Nucleus KW - Phosphotransferases KW - Intracellular Space KW - Transferases KW - Enzymes KW - Cellular Structures KW - Enzymes and Coenzymes KW - Cells KW - Anatomy KW - Oncology KW - Medicine KW - Health & Biological Sciences KW - Therapeutic use. KW - Molecular aspects. KW - Drug therapy. KW - Genetics. KW - Molecular aspects KW - Telomere. KW - Medicine. KW - Cancer research. KW - Pharmacology. KW - Oncology. KW - Biomedicine. KW - Cancer Research. KW - Pharmacology/Toxicology. KW - Tumors KW - Drug effects KW - Medical pharmacology KW - Medical sciences KW - Chemicals KW - Chemotherapy KW - Drugs KW - Pharmacy KW - Cancer research KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Pathology KW - Physicians KW - Physiological effect KW - DNA polymerases KW - Oncology . KW - Toxicology. KW - Pharmacology KW - Poisoning KW - Poisons KW - Toxicology UR - https://www.unicat.be/uniCat?func=search&query=sysid:8654893 AB - Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase positive cells, and consequence of telomerase inhibition are different among species. "Telomeres and Telomerase in Cancers", edited by Keiko Hiyama, focuses on "Human" telomeres and telomerase, from basic biology and hypothesis in human normal cells and cancer cells to clinical application as diagnostic tools and therapeutic targets in anti-cancer strategy. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date entire picture of human telomeres and telomerase in cancer. ER -