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Sciences and technologies are extending design fields, modifying materials and everything that surround us, even our body, redefining on a perceptive level the boundary between things and us. To identify the actual evolution of the relationship between sciences, knowledge and design, the Madec (Material Design Culture Research Centre) of Politecnico di Milano, started in 2014 a wide debate with a series of contributions about innovation trajectories with well known scholars of many disciplines, researchers, professionals and companies. This public debate, entitled "Ideas and the matter" opens new options for design action today, new ideas, and the definition of design approaches, contributing to the development of a new methodology of creativity-driven material innovation that, in a world full of opportunities but also problems to be solved, helps design to play a role of "giving new meanings", through designing materials and things with a critical approach. This is a mission designers cannot abdicate, following the successes of "Design Thinking", which was opening up to social innovation challenges and achieving creative solutions beyond the reach of conventional structure and method. At the same time, "Open innovation" is a go-to process stimulating way of creating positive change in production. This book is the compendium of Madec's one-year research. The contributors of the book come from several and diverse disciplines (medicine, biotechnology, engineering, art, anthropology, architecture and design), which design thoughts are fed by.