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The Moral, Social, and Commercial Imperatives of Genetic Testing and Screening : The Australian Case
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ISBN: 1280935669 9786610935666 1402046197 1402046189 9048171547 Year: 2006 Volume: v. 30 Publisher: Dordrecht : Springer Netherlands : Imprint: Springer,

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Abstract

This is a dynamic book that successfully combines global and local thinking with regard to an emerging technology that will contribute to the expansion of proteomics and pharmacogenomics, the science of tailored healthcare and treatments. Genetic testing and screening will change the way people understand health, diagnostic knowledge, illness but also crime, databases and private information, paternity, and self-knowledge. In addition to giving individuals the opportunity to think differently about their well-being, it installs a new taxonomy in terms of illness, because its probabilistic effects will introduce a new narrative in the health discourse of 21st century society. While in the past people could be classified as being healthy or sick, now, through genetic testing and screening, adults can be classified as being healthy, predisposed to an illness, probably at risk, at risk, or carriers of certain risks. The effects of this taxonomy do not remain confined to the individual who is tested but extends to an entire family, as genetic knowledge is family knowledge. But the technology of genetic testing and screening installs a second dramatic register in the prenatal phase when cells and embryos are tested and subsequently altered in order to hit targets of perfection. However, this technology can also be seen as a strategy for the acquisition of new knowledge about oneself, as it instigates a different attitude towards ourselves in a scenario in which the notion of life as a singular noun is seriously questioned by cultural practices that make it necessary to speak of forms of life. The complexity of the Self resulting from this epistemological shift evoke the ancient Greco-roman practices of the care of the self leading to self-knowledge. Genetic testing and screening could therefore be understood as a form of self-quest, and attempt to discover what we are beyond our wishes and desires - beyond what we would like to be.


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Introduction to Computational Biology : An Evolutionary Approach
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ISBN: 3764373873 Year: 2006 Publisher: Basel : Birkhäuser Basel,

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Molecular biology has changed dramatically over the past two decades. Until the early 1990s genes were studied one at a time by small teams of researchers; today entire genomes are sequenced by internationally collaborating laboratories. In the bygone gene-centered era the accumulation of data was the rate-limiting step in research. Now that step is often data interpretation. This is increasingly dependent on computational methods and as a consequence, computational biology has emerged in the past decade as a new subdiscipline of biology. This introduction to computational biology is centered on the analysis of molecular sequence data. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models. In the second part evolutionary time takes center stage and phylogenetic reconstruction, the analysis of sequence variation, and the dynamics of genes in populations are explained in detail. In addition, the book contains a computer program with a graphical user interface that allows the reader to experiment with a number of key concepts developed by the authors. Introduction to Computational Biology is intended for students enrolled in courses in computational biology or bioinformatics as well as for molecular biologists, mathematicians, and computer scientists. Bernhard Haubold is associate professor at the University of Applied Sciences, Weihenstephan, Germany. Thomas Wiehe is associate professor at the University of Cologne, Germany.

Genetic engineering : principles and methods
Author:
ISBN: 0306401541 0306404478 0306407299 030641113X 0306413825 0306417103 9780306466458 0306466457 9780306475726 9780387258553 0387258558 9780387258560 9780387338408 0387338403 9780387345048 9786610200603 128020060X 0306475723 148997363X 9786610608317 1280608315 0387258566 9786610817047 1280817046 0387345043 1468447955 1468447939 1461570743 1461570727 1461570778 1461570751 1461570808 1461570786 1468445588 1468445561 Year: 2007 Publisher: New York, N.Y. : Springer,

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Genetic Engineering: Principles & Methods Jane K. Setlow, PhD Brookhaven National Laboratory, Upton, NY, USA About the Series: Genetic Engineering: Principles and Methods presents state-of-the-art discussions in modern genetics and genetic engineering. Recent volumes have covered gene therapy research, genetic mapping, plant science and technology, transport protein biochemistry, and viral vectors in gene therapy, among many other topics. Volume Key Features: Genetic Engineering: Principles and Methods, Volume 28 contains discussions of contemporary and relevant topics in genetics, including: Regulation of Plant Intracellular Communication Via Plasmodesmata Root-knot and Cyst Nematode Parasitism Genes: The Molecular Basis of Plant Parasitism Mutagenesis of Human p53 Tumor Supressor Gene Sequences in Embryonic Fibroblasts of Genetically Engineered Mice Salicylic Acid, Jasmonic Acid and Ethylene-Mediated Regulation of Plant Defense Signaling Proximity Ligation: A Specific and Versatile Tool for the Proteomic Era Protein Overexpression in Mammilian Cell Lines A High-Throughput Approach to Protein Structure Analysis New Mass-Spectrometry-Based Strategies for Lipids Paired-End Genomic Signature Tags: A Method for the Functional Analysis of Genomes and Epigenomes All chapter titles are original content by the authors This principles and methods approach to genetics and genetic engineering is essential reading for all academics, bench scientists, and industry professionals wishing to take advantage of the latest and greatest in this continuously emerging field. About the Editor: Jane K. Setlow, PhD. has championed the field of genetics for over 30 years, agreeing to edit Genetic Engineering: Principles & Methods since its inception in 1979. An internationally recognized scientist with numerous publications, Dr. Setlow is the former Chairperson of the NIH Recombinant DNA Molecule Advisory Committee (RAC). Her lab can found at Brookhaven National Laboratory, Upton, New York.


Book
Telomeres and Telomerase in Cancer
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ISBN: 1282047922 9786612047923 1603278796 1603273069 1617378887 Year: 2009 Publisher: Totowa, NJ : Humana Press : Imprint: Humana,

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Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase positive cells, and consequence of telomerase inhibition are different among species. "Telomeres and Telomerase in Cancers", edited by Keiko Hiyama, focuses on "Human" telomeres and telomerase, from basic biology and hypothesis in human normal cells and cancer cells to clinical application as diagnostic tools and therapeutic targets in anti-cancer strategy. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date entire picture of human telomeres and telomerase in cancer.

Keywords

Antineoplastic agents --- Cancer --- Cell transformation, Neoplastic. --- Neoplasms --- Telomerase. --- Telomere --- Telomerase --- Cell Transformation, Neoplastic --- Telomere-Binding Proteins --- Antineoplastic Agents --- Genetics --- Drug Therapy --- Ribonucleoproteins --- Neoplastic Processes --- Therapeutic Uses --- Diseases --- Therapeutics --- Chromosome Structures --- Biology --- DNA-Binding Proteins --- Chromosomal Proteins, Non-Histone --- RNA-Directed DNA Polymerase --- Nuclear Proteins --- DNA-Directed DNA Polymerase --- Pathologic Processes --- RNA-Binding Proteins --- Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharmacologic Actions --- Biological Science Disciplines --- Genetic Structures --- Chromosomes --- Natural Science Disciplines --- Pathological Conditions, Signs and Symptoms --- Amino Acids, Peptides, and Proteins --- Nucleoproteins --- DNA Nucleotidyltransferases --- Genetic Phenomena --- Intranuclear Space --- Carrier Proteins --- Chemical Actions and Uses --- Chemicals and Drugs --- Cell Nucleus Structures --- Nucleotidyltransferases --- Disciplines and Occupations --- Phenomena and Processes --- Cell Nucleus --- Phosphotransferases --- Intracellular Space --- Transferases --- Enzymes --- Cellular Structures --- Enzymes and Coenzymes --- Cells --- Anatomy --- Oncology --- Medicine --- Health & Biological Sciences --- Therapeutic use. --- Molecular aspects. --- Drug therapy. --- Genetics. --- Molecular aspects --- Telomere. --- Medicine. --- Cancer research. --- Pharmacology. --- Oncology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Tumors --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- DNA polymerases --- Oncology  . --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Toxicology

Chromatin Dynamics in Cellular Function
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ISBN: 9783540336853 3540336850 3540336877 Year: 2006 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,

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This volume includes timely reviews of several aspects of chromatin biology written by scientists at the forefront of this rapidly moving field. Topics covered include the structure and function of protein modules within chromatin-remodeling proteins, newly characterized histone modifications (methylation, ubiquitylation) and their functional consequences, transcription and histone dynamics, roles of chromatin remodeling factors in DNA replication and repair, and current models of nucleosome-remodeling mechanisms.

Keywords

Chromatin Assembly and Disassembly. --- Cell Physiology. --- Histones. --- Chromatin. --- Chromatine --- Life sciences. --- Biochemistry. --- Cytology. --- Life Sciences. --- Cell Biology. --- Biochemistry, general. --- Chromatin --- Histones --- Chromatin Assembly and Disassembly --- Cell Physiological Phenomena --- DNA Packaging --- Gene Expression Regulation --- Nuclear Proteins --- Nucleoproteins --- Chromosome Structures --- Phenomena and Processes --- Proteins --- Genetic Structures --- Genetic Processes --- Cell Physiological Processes --- Chromosomes --- Amino Acids, Peptides, and Proteins --- Intranuclear Space --- Genetic Phenomena --- Chemicals and Drugs --- Cell Nucleus Structures --- Cell Nucleus --- Intracellular Space --- Cellular Structures --- Cells --- Anatomy --- Cytology --- Biology --- Health & Biological Sciences --- Biosciences --- Sciences, Life --- Anatomies --- Cell --- Cell Components --- Cell Component --- Cellular Structure --- Component, Cell --- Components, Cell --- Structure, Cellular --- Structures, Cellular --- Cell Nuclei --- Nuclei, Cell --- Nucleus, Cell --- Cell Nucleus Structure --- Structure, Cell Nucleus --- Structures, Cell Nucleus --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Chromosome --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Genetic Structure --- Structure, Genetic --- Structures, Genetic --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Chromosome Structure --- Structure, Chromosome --- Structures, Chromosome --- Nucleoprotein --- Nuclear Protein --- Nucleolar Proteins --- Protein, Nuclear --- Proteins, Nuclear --- Proteins, Nucleolar --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- Packaging, DNA --- Chromatin Assembly --- Chromatin Disassembly --- Chromatin Modeling --- Chromatin Remodeling --- Chromatin Disassemblies --- Disassembly, Chromatin --- Remodeling, Chromatin --- Chromatins --- Histone --- Histone H1 --- Histone H1(s) --- Histone H2a --- Histone H2b --- Histone H3 --- Histone H3.3 --- Histone H4 --- Histone H5 --- Histone H7 --- Cell biology --- Cellular biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- physiology --- Composition --- Subcellular Space --- Intracellular Spaces --- Space, Intracellular --- Space, Subcellular --- Spaces, Intracellular --- Spaces, Subcellular --- Subcellular Spaces --- Subnuclear Space --- Intranuclear Spaces --- Space, Intranuclear --- Space, Subnuclear --- Spaces, Intranuclear --- Spaces, Subnuclear --- Subnuclear Spaces --- Cell biology. --- Cytologists --- Chemistry --- Medical sciences

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