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Marschall S. Runge, MD, PhD, Cam Patterson, MD, and a panel of 251 authoritative contributors-many of them world-renowned clinicians and researchers-have now updated and expanded the much-acclaimed first edition of Principles of Molecular Medicine to provide an integrated survey of the basic principles of internal medicine in the light of recent dramatic discoveries in molecular medicine and new technologies for the diagnosis and treatment of human disease. This second edition contains new sections on genetics, oncology, metabolic diseases, and infectious diseases, in addition to fully revised sections on neurology, cardiology, hematology, nephrology, endocrinology, dermatology, immunology, gastroenterology, pulmonary disease, musculoskeletal medicine, and psychiatry. Here, the reader will discover the latest findings about direct links between genetic mutations and diseases, genomic approaches to a variety of diseases, and stem cell populations that regenerate muscle, heart, and neural cell populations. Other advances elucidated include the roles of bone morphogenetic proteins in pulmonary hypertension, mutations involved in an array of cardiomyopathies, and new understanding of the biology of previously untreatable neurodegenerative diseases, such as Huntington's disease. For this edition, the authors have also focused on producing a tightly written text with more useful figures and tables and reduced references, so that the text is more immediately useful but not overwhelming as a reference book. A CD-ROM edition of the book (ISBN: 1-58829-929-5) is available separately. Comprehensive and state-of-the-art, Principles of Molecular Medicine, Second Edition, offers practicing physicians, researchers, and residents an extraordinary summary of the rapidly emerging molecular mechanisms underlying disease and valuable insights into the nature and direction of future developments.