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Animal disease models are a vital tool to study diseases and associated conditions. Studies on animal models can, in some cases, be used as a basis for modeling and understanding human diseases. Biomedical scientists face a challenge to choose the correct animal model to study disease pathology, and neurological diseases are no exception to this rule. Animal Models for Neurological Disorders covers different animal models which have been used for studying neurological disorders. 13 topical chapters have been contributed by a group of experts on the subject with an aim to cover emerging experimental models of a range of neurological diseases encountered in the clinic including Alzheimer's disease, psychosis, Parkinson's, Huntington's disease, vascular dementia, schizophrenia, multiple sclerosis and brain tumors, among others. The chapters also inform readers about relevant clinical correlations in each disease model where appropriate.
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Neurology, more perhaps than any other branch of medicine, is dependent on an accurate knowledge of anatomy as a basis for the intelligent diagnosis and localization of neural disturbances. This book, the result of many years of neuroanatomical teaching, is intended to supply this basic anatomical need, to give the student and physician a thorough and clear presentation of the structural mechanisms of the human nervous system together with some understanding of their functional and clinical significance. It is an attempt to link structure and function into a dynamic pattern without sacrificing anatomical detail. The book is a human neuroanatomy sufficiently rich in content to obviate the necessity of constantly consulting larger anatomical texts. It may be conveniently divided into two parts. The first part (Chapters I-VIII) is concerned with the general organization and meaning of the nervous system, its embryology and histological structure, and with some fundamental neurological problems as they apply to man. This is followed by a discussion of the organization and segmental distribution of the peripheral nerve elements, including an analysis of the functional components of the spinal nerves and of the various receptors and effectors. If these earlier chapters are perhaps more extensive than in most other texts, it is due to the conviction that the book should be complete in itself, and also that a knowledge of these preliminaries is essential for an understanding of the complex machinery of the spinal cord and brain. The second and larger part (Chapter IX-XX) is devoted to the architectonics of the central nervous system and may be regarded as "applied neuroanatomy." Special features of this part are the many fine photographs, both gross and microscopic, of the human brain and spinal cord, the great wealth of anatomical detail, and the discussion of the structural mechanisms in the light of clinical experience. While the individual portions of the nervous system are treated separately, an attempt has been made to achieve organic structural continuity by judicious repetition and overlapping and by constant reference to related topics already familiar to the student from previous chapters. The plan of exposition is substantially the same for each topic. The gross structure and relationships are concisely but thoroughly reviewed with the aid of clear and graphic illustrations. The internal structure is then presented in detail, usually based on a carefully graded series of fine and clearly labeled microphotographs of human material. At each level the student is familiarized with the exact location, extent and relationships of the various structures seen in the section. Finally the anatomical features of each part are reviewed more comprehensively as three-dimensional structural mechanisms, with a full discussion of their connections and clinical significance. We believe that this treatment will make the complicated structural details alive and interesting to the student. The illustrations are not segregated in the back of the book in the form of an atlas but are scattered in the text, in proper relation to the levels studied.
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