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Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.
Peptidase --- Transpeptidation --- Aminoacyltransferases --- Biological Science Disciplines --- Acyltransferases --- Natural Science Disciplines --- Transferases --- Disciplines and Occupations --- Enzymes --- Enzymes and Coenzymes --- Chemicals and Drugs --- gamma-Glutamyltransferase --- Physiology --- Transglutaminases --- Chemistry --- Physical Sciences & Mathematics --- Biochemistry --- Peptidase. --- Transpeptidation. --- Life sciences. --- Human physiology. --- Biochemical engineering. --- Enzymology. --- Life Sciences. --- Human Physiology. --- Biochemical Engineering. --- Proteins --- Proteolytic enzymes --- Synthesis --- Enzymes. --- Bio-process engineering --- Bioprocess engineering --- Biotechnology --- Chemical engineering --- Human biology --- Medical sciences --- Human body --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Enzymology
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In Building Reuse: Sustainability, Preservation, and the Value of Design, Kathryn Rogers Merlino makes an impassioned case that truly sustainable design requires reusing and reimagining existing buildings. The construction and operation of buildings is responsible for 41 percent of all primary energy use and 48 percent of all carbon emissions. The impact of the demolition and removal of an older building can greatly diminish the advantages of adding green technologies to new construction. Reusing existing buildings can be challenging to accomplish, but changing the way we think about environmentally conscious architecture has the potential to significantly reduce carbon emissions. Additionally, Merlino calls for a more expansive view of historic preservation that goes beyond keeping only the most distinctive structures and requiring that they remain fundamentally unchanged to embracing the creative reuse of even unremarkable buildings. In support of these points, Building Reuse includes a compelling range of case studies-from an eighteen-story office building to a private home-all located in the Pacific Northwest, a region with a long history of sustainable design and urban growth policies that have made reuse projects feasible.
Architecture --- architecture [discipline] --- adaptive reuse --- preservation [function] --- sustainable architecture --- North America --- Sustainable architecture. --- Buildings --- Architecture and society. --- Architecture and sociology --- Society and architecture --- Sociology and architecture --- Adaptive reuse of buildings --- Buildings, Restoration of --- Conservation of buildings --- Restoration of buildings --- Eco-architecture --- Environmentally conscious architecture --- Environmentally friendly architecture --- Green architecture --- Green building design --- Green design (Buildings) --- Sustainable design (Buildings) --- Sustainable design --- Conservation and restoration. --- Remodeling for other use. --- Social aspects --- Human factors --- Adaptive reuse --- Conservation and restoration --- Restoration --- Repair and reconstruction --- Sustainable architecture --- Architecture and society --- Remodeling for other use --- 750.5 --- genbrug --- transformation --- konvertering til nye formål --- Halls
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