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Biopharmaco-efficiency. Pharmacokinetics --- Drug resistance in cancer cells --- Cancer --- Cellules cancéreuses --- Periodicals. --- Chemotherapy --- Résistance aux médicaments --- Périodiques --- Chimiothérapie --- Drug resistance in microorganisms --- Drug Resistance. --- Antineoplastic Agents. --- Anti-Infective Agents. --- Communicable Diseases --- Neoplasms --- Micro-organismes --- Drug resistance in cancer cells. --- Drug resistance in microorganisms. --- drug therapy. --- Resistance, Drug --- Pharmacogenetics --- Anticancer Agents --- Antineoplastic Drugs --- Antineoplastics --- Antitumor Agents --- Antitumor Drugs --- Cancer Chemotherapy Agents --- Cancer Chemotherapy Drugs --- Chemotherapeutic Anticancer Agents --- Chemotherapeutic Anticancer Drug --- Agents, Anticancer --- Agents, Antineoplastic --- Agents, Antitumor --- Agents, Cancer Chemotherapy --- Agents, Chemotherapeutic Anticancer --- Chemotherapy Agents, Cancer --- Chemotherapy Drugs, Cancer --- Drug, Chemotherapeutic Anticancer --- Drugs, Antineoplastic --- Drugs, Antitumor --- Drugs, Cancer Chemotherapy --- Cytotoxins --- Interferon Inducers --- Anticarcinogenic Agents --- Periodicals --- Agriculture Sciences --- Chemistry --- Health Sciences --- Life Sciences --- Soil Chemistry, Microbiology, Fertility & Fertilizers --- Biochemistry --- General and Others --- Oncology --- Anti-Microbial Agents --- Antiinfective Agents --- Antimicrobial Agents --- Microbicides --- Agents, Anti-Infective --- Agents, Anti-Microbial --- Agents, Antiinfective --- Agents, Antimicrobial --- Anti Infective Agents --- Anti Microbial Agents --- Infection --- Parasites --- Infections --- farmacologie --- biogeneesmiddelen --- Anticancer Agent --- Antineoplastic --- Antineoplastic Agent --- Antineoplastic Drug --- Antitumor Agent --- Antitumor Drug --- Cancer Chemotherapy Agent --- Cancer Chemotherapy Drug --- Agent, Anticancer --- Agent, Antineoplastic --- Agent, Antitumor --- Agent, Cancer Chemotherapy --- Chemotherapy Agent, Cancer --- Chemotherapy Drug, Cancer --- Drug, Antineoplastic --- Drug, Antitumor --- Drug, Cancer Chemotherapy --- Anti-Infective Agent --- Anti-Microbial Agent --- Antimicrobial Agent --- Microbicide --- Agent, Anti-Infective --- Agent, Anti-Microbial --- Agent, Antimicrobial --- Anti Infective Agent --- Anti Microbial Agent --- Anti-Infective Agents --- Antineoplastic Agents --- Drug Resistance --- drug therapy

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Interferons --- Antiviral Agents --- Antineoplastic Agents --- Leukocytes --- Fibroblasts --- Neoplasms --- DNA, Recombinant --- Recombinant DNA Research --- Recombination Joint --- Genes, Spliced --- Recombinant DNA --- DNA Research, Recombinant --- Joint, Recombination --- Research, Recombinant DNA --- Spliced Genes --- Cloning, Molecular --- DNA Transposable Elements --- Genetic Engineering --- Genetic Vectors --- Genomic Library --- Gene Library --- Artificial Gene Fusion --- Fibroblast --- White Blood Corpuscles --- Blood Cells, White --- Blood Corpuscles, White --- White Blood Cells --- Blood Cell, White --- Blood Corpuscle, White --- Corpuscle, White Blood --- Corpuscles, White Blood --- Leukocyte --- White Blood Cell --- White Blood Corpuscle --- Anticancer Agents --- Antineoplastic Drugs --- Antineoplastics --- Antitumor Agents --- Antitumor Drugs --- Cancer Chemotherapy Agents --- Cancer Chemotherapy Drugs --- Chemotherapeutic Anticancer Agents --- Chemotherapeutic Anticancer Drug --- Agents, Anticancer --- Agents, Antineoplastic --- Agents, Antitumor --- Agents, Cancer Chemotherapy --- Agents, Chemotherapeutic Anticancer --- Chemotherapy Agents, Cancer --- Chemotherapy Drugs, Cancer --- Drug, Chemotherapeutic Anticancer --- Drugs, Antineoplastic --- Drugs, Antitumor --- Drugs, Cancer Chemotherapy --- Cytotoxins --- Interferon Inducers --- Anticarcinogenic Agents --- Antiviral Drugs --- Antivirals --- Agents, Antiviral --- Drugs, Antiviral --- Virus Diseases --- Viruses --- Virus Inactivation --- Interferon --- Viral Interference --- drug therapy --- FINTER, Norman B. --- interferon (XXXIII.5.) GENETICS (XII.) GENETIC ENGINEERING --- biotechnology (XI) BIOLOGY (IV.) --- interferon (XXXIII.5.) --- Sred --- Interferon. --- Antineoplastic agents --- Antiviral agents --- Glycoproteins --- Lymphokines --- virology --- Sect --- Prim --- Anticancer Agent --- Antineoplastic --- Antineoplastic Agent --- Antineoplastic Drug --- Antitumor Agent --- Antitumor Drug --- Cancer Chemotherapy Agent --- Cancer Chemotherapy Drug --- Agent, Anticancer --- Agent, Antineoplastic --- Agent, Antitumor --- Agent, Cancer Chemotherapy --- Chemotherapy Agent, Cancer --- Chemotherapy Drug, Cancer --- Drug, Antineoplastic --- Drug, Antitumor --- Drug, Cancer Chemotherapy --- Antiviral --- Antiviral Agent --- Antiviral Drug --- Agent, Antiviral --- Drug, Antiviral --- FINTER, Norman B

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Oncology --- Antineoplastic agents --- Tumors in children --- Antineoplastic Agents. --- Medical Oncology. --- Neoplasms. --- Antineoplastic agents. --- Oncology. --- Tumors in children. --- India. --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Clinical Oncology --- Oncology, Medical --- Oncology, Clinical --- Anticancer Agents --- Antineoplastic Drugs --- Antineoplastics --- Antitumor Agents --- Antitumor Drugs --- Cancer Chemotherapy Agents --- Cancer Chemotherapy Drugs --- Chemotherapeutic Anticancer Agents --- Chemotherapeutic Anticancer Drug --- Agents, Anticancer --- Agents, Antineoplastic --- Agents, Antitumor --- Agents, Cancer Chemotherapy --- Agents, Chemotherapeutic Anticancer --- Chemotherapy Agents, Cancer --- Chemotherapy Drugs, Cancer --- Drug, Chemotherapeutic Anticancer --- Drugs, Antineoplastic --- Drugs, Antitumor --- Drugs, Cancer Chemotherapy --- Pediatric oncology --- Anticancer agents --- Antineoplastic drugs --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Bharat --- Bhārata --- Government of India --- Ḣindiston Respublikasi --- Inde --- Indië --- Indien --- Indii︠a︡ --- Indland --- Republic of India --- Sāthāranarat ʻIndīa --- Yin-tu --- Antineoplastic Agents --- Medical Oncology --- Neoplasms --- Children --- Drugs --- Malignant Neoplasms --- Malignant Neoplasm --- Neoplasm, Malignant --- Neoplasms, Malignant --- Cytotoxins --- Interferon Inducers --- Anticarcinogenic Agents --- Diseases --- Chemotherapy --- Indi --- Indii͡ --- Health Sciences --- Clinical Medicine --- Indo --- Anticancer Agent --- Antineoplastic --- Antineoplastic Agent --- Antineoplastic Drug --- Antitumor Agent --- Antitumor Drug --- Cancer Chemotherapy Agent --- Cancer Chemotherapy Drug --- Agent, Anticancer --- Agent, Antineoplastic --- Agent, Antitumor --- Agent, Cancer Chemotherapy --- Chemotherapy Agent, Cancer --- Chemotherapy Drug, Cancer --- Drug, Antineoplastic --- Drug, Antitumor --- Drug, Cancer Chemotherapy --- India

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This book provides a detailed review of how oncology drug development has changed over the past decade, and serves as a comprehensive guide for the practicalities in setting up phase I trials. The book covers strategies to accelerate the development of novel antitumor compounds from the laboratory to clinical trials and beyond through the use of innovative mechanism-of-action pharmacodynamic biomarkers and pharmacokinetic studies. The reader will learn about all aspects of modern phase I trial designs, including the incorporation of precision medicine strategies, and approaches for rational patient allocation to novel anticancer therapies. Circulating biomarkers to assess mechanisms of response and resistance are changing the way we are assessing patient selection and are also covered in this book. The development of the different classes of antitumor agents are discussed, including chemotherapy, molecularly targeted agents, immunotherapies and also radiotherapy. The authors also discuss the lessons that the oncology field has learnt from the development of hematology-oncology drugs and how such strategies can be carried over into therapies for solid tumors. There is a dedicated chapter that covers the specialized statistical approaches necessary for phase I trial designs, including novel Bayesian strategies for dose escalation. This volume is designed to help clinicians better understand phase I clinical trials, but would also be of use to translational researchers (MDs and PhDs), and drug developers from academia and industry interested in cancer drug development. It could also be of use to phase I trial study coordinators, oncology nurses and advanced practice providers. Other health professionals interested in the treatment of cancer will also find this book of great value. .

Oncology  . --- Radiotherapy. --- Oncology. --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Tumors --- Radiological services --- Antineoplastic agents --- Cancer --- Drug development. --- Design. --- Chemotherapy. --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Development --- Treatment --- Chemotherapy --- Antineoplastic Agents. --- Drug Development. --- Neoplasms --- Clinical Trials, Phase I as Topic. --- drug therapy. --- Clinical Trials, Phase 1 --- Drug Evaluation, FDA Phase 1 --- Drug Evaluation, FDA Phase I as Topic --- Evaluation Studies, FDA Phase 1 --- Human Microdosing Trials --- Microdosing Trials, Human --- Phase 1 Clinical Trials --- Clinical Trials, Phase I --- Drug Evaluation, FDA Phase I --- Evaluation Studies, FDA Phase I --- Human Microdosing Trial --- Phase 1 Clinical Trial --- Phase I Clinical Trial --- Phase I Clinical Trials --- Microdosing Trial, Human --- Trial, Human Microdosing --- Trials, Human Microdosing --- Nontherapeutic Human Experimentation --- Medication Development --- Pharmaceutical Development --- Computational Prediction of Drug-Target Interactions --- Drug Target Prediction --- Development, Drug --- Development, Medication --- Development, Pharmaceutical --- Drug Target Predictions --- Prediction, Drug Target --- Target Prediction, Drug --- Anticancer Agents --- Antineoplastic Drugs --- Antitumor Agents --- Antitumor Drugs --- Cancer Chemotherapy Agents --- Cancer Chemotherapy Drugs --- Chemotherapeutic Anticancer Agents --- Chemotherapeutic Anticancer Drug --- Anticancer Agent --- Antineoplastic --- Antineoplastic Agent --- Antineoplastic Drug --- Antitumor Agent --- Antitumor Drug --- Cancer Chemotherapy Agent --- Cancer Chemotherapy Drug --- Agent, Anticancer --- Agent, Antineoplastic --- Agent, Antitumor --- Agent, Cancer Chemotherapy --- Agents, Anticancer --- Agents, Antineoplastic --- Agents, Antitumor --- Agents, Cancer Chemotherapy --- Agents, Chemotherapeutic Anticancer --- Chemotherapy Agent, Cancer --- Chemotherapy Agents, Cancer --- Chemotherapy Drug, Cancer --- Chemotherapy Drugs, Cancer --- Drug, Antineoplastic --- Drug, Antitumor --- Drug, Cancer Chemotherapy --- Drug, Chemotherapeutic Anticancer --- Drugs, Antineoplastic --- Drugs, Antitumor --- Drugs, Cancer Chemotherapy --- Cytotoxins --- Interferon Inducers --- Anticarcinogenic Agents

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Cardiovascular toxicology. --- Cardiotoxicity. --- Drug-Related Side Effects and Adverse Reactions. --- Antineoplastic Agents. --- Radiotherapy --- Anticancer Agents --- Antineoplastic Drugs --- Antineoplastics --- Antitumor Agents --- Antitumor Drugs --- Cancer Chemotherapy Agents --- Cancer Chemotherapy Drugs --- Chemotherapeutic Anticancer Agents --- Chemotherapeutic Anticancer Drug --- Anticancer Agent --- Antineoplastic --- Antineoplastic Agent --- Antineoplastic Drug --- Antitumor Agent --- Antitumor Drug --- Cancer Chemotherapy Agent --- Cancer Chemotherapy Drug --- Agent, Anticancer --- Agent, Antineoplastic --- Agent, Antitumor --- Agent, Cancer Chemotherapy --- Agents, Anticancer --- Agents, Antineoplastic --- Agents, Antitumor --- Agents, Cancer Chemotherapy --- Agents, Chemotherapeutic Anticancer --- Chemotherapy Agent, Cancer --- Chemotherapy Agents, Cancer --- Chemotherapy Drug, Cancer --- Chemotherapy Drugs, Cancer --- Drug, Antineoplastic --- Drug, Antitumor --- Drug, Cancer Chemotherapy --- Drug, Chemotherapeutic Anticancer --- Drugs, Antineoplastic --- Drugs, Antitumor --- Drugs, Cancer Chemotherapy --- Cytotoxins --- Interferon Inducers --- Anticarcinogenic Agents --- Adverse Drug Event --- Adverse Drug Reaction --- Drug Side Effects --- Drug Toxicity --- Side Effects of Drugs --- Toxicity, Drug --- Adverse Drug Events --- Adverse Drug Reactions --- Drug Event, Adverse --- Drug Events, Adverse --- Drug Reaction, Adverse --- Drug Reactions, Adverse --- Drug Related Side Effects and Adverse Reactions --- Drug Side Effect --- Drug Toxicities --- Effects, Drug Side --- Reactions, Adverse Drug --- Side Effect, Drug --- Side Effects, Drug --- Toxicities, Drug --- Drug Therapy --- Pharmaceutical Preparations --- Contraindications, Drug --- Drug Interactions --- Clinical Trials, Phase IV as Topic --- Cardiac Toxicity --- Cardiac Toxicities --- Cardiotoxicities --- Toxicity, Cardiac --- Cardiovascular toxicity --- Toxicology --- adverse effects. --- adverse effects --- toxicity --- Heart --- Effect of drugs on. --- Cardiovascular pharmacology --- Drug effects