Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The fourth, completely revised edition of this classic reference and textbook presents a cohesive and up-to-date exposition of the concepts, results, and problems underlying theory and practice in human and medical genetics. In the 10 years since the appearance of the third edition, many new insights have emerged for understanding the genetic basis of development and function in human health and disease. Human genetics, with its emphasis on molecular concepts and techniques, has become a key discipline in medicine and the biomedical sciences. The fourth edition has been extensively expanded by new chapters on timely topics such as epigenetics, pharmacogenetics, gene therapy, cloning, and genetic epidemiology, and databases for basic and clinical genetics. In addition a multi/chapter section giving an overview on the main model organisms (mouse, dog, worm, fly, fish) used in human genetics research has been introduced. This book will be of interest to human and medical geneticists, scientists in all biomedical sciences, physicians and epidemiologists, as well as to graduate and postgraduate students who desire to learn the fundamentals of this fascinating field.

Genetics, Medical. --- Human genetics. --- Human genetics --- Medicine --- Biology --- Health Occupations --- Biological Science Disciplines --- Genetics, Medical --- Genetics --- Natural Science Disciplines --- Disciplines and Occupations --- Health & Biological Sciences --- Pathology --- Genetics. --- Medicine. --- Biomedicine. --- Human Genetics. --- Heredity, Human --- Human biology --- Physical anthropology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Xenética humana

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ‘80s-mid ‘90s, neoplastic growth was described largely as a net imbalance between cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc . Nevertheless, the commonly held view is that changes in tumor microenvironment are "soft-wired", i.e. epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these cell-extrinsic changes might be one of the primary reasons such mutations are preserved in late-stage tumors. Cancer Genome and Tumor Microenvironment reviews how tumor microenvironment and progression can be "hard-wired", i.e. genetically controlled.

Cancer -- Molecular aspects -- Congresses. --- Molecular Biology -- Methods -- Congresses. --- Neoplasms -- Genetics -- Congresses. --- Tumors --- Genomics --- Cancer --- Biology --- Diseases --- Computational Biology --- Genetics --- Neoplasms --- Biological Science Disciplines --- Natural Science Disciplines --- Disciplines and Occupations --- Medicine --- Oncology --- Health & Biological Sciences --- Genetic aspects --- Immunology --- Carcinogenesis. --- Oncology. --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathogenesis --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Pathology --- Genetic toxicology --- Oncology  . --- Cancer research

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book applies methods from nonlinear dynamics to problems in neuroscience. It uses modern mathematical approaches to understand patterns of neuronal activity seen in experiments and models of neuronal behavior. The intended audience is researchers interested in applying mathematics to important problems in neuroscience, and neuroscientists who would like to understand how to create models, as well as the mathematical and computational methods for analyzing them. The authors take a very broad approach and use many different methods to solve and understand complex models of neurons and circuits. They explain and combine numerical, analytical, dynamical systems and perturbation methods to produce a modern approach to the types of model equations that arise in neuroscience. There are extensive chapters on the role of noise, multiple time scales and spatial interactions in generating complex activity patterns found in experiments. The early chapters require little more than basic calculus and some elementary differential equations and can form the core of a computational neuroscience course. Later chapters can be used as a basis for a graduate class and as a source for current research in mathematical neuroscience. The book contains a large number of illustrations, chapter summaries and hundreds of exercises which are motivated by issues that arise in biology, and involve both computation and analysis. Bard Ermentrout is Professor of Computational Biology and Professor of Mathematics at the University of Pittsburgh. David Terman is Professor of Mathematics at the Ohio State University.

Brain -- Models. --- Computational neuroscience. --- Neurosciences -- Mathematics. --- Neurosciences --- Computational neuroscience --- Natural Science Disciplines --- Biological Science Disciplines --- Mathematics --- Disciplines and Occupations --- Biology --- Medicine --- Human Anatomy & Physiology --- Neuroscience --- Biology - General --- Neurology --- Health & Biological Sciences --- Mathematics. --- Computational neurosciences --- Neural sciences --- Neurological sciences --- Neurosciences. --- Neurobiology. --- Biomathematics. --- Mathematical and Computational Biology. --- Medical sciences --- Nervous system --- Math --- Science --- Computational biology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

A survey of the emerging field of neuroethics that calls for a multidisciplinary, pragmatic approach for tackling key issues and improving patient care.

Neurology --- Neurosciences. --- Neurologie --- Neurosciences --- Moral and ethical aspects --- Aspect moral --- SELF-HELP --- General --- Behavior --- Bioethical Issues --- Morals --- Ethics --- Behavior and Behavior Mechanisms --- Biological Science Disciplines --- Medicine --- Psychology, Social --- Humanities --- Health Occupations --- Natural Science Disciplines --- Psychiatry and Psychology --- Philosophy --- Disciplines and Occupations --- Health & Biological Sciences --- Bioethical Issues. --- Morals. --- Moral and ethical aspects. --- ethics. --- Ethics. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Neuropsychiatry --- Diseases --- PHILOSOPHY/Ethics & Bioethics --- NEUROSCIENCE/General

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The 8 recurring volumes of the "Essentials in Ophthalmology" series cover the most recent developments in one of eight subspecialties in Ophthalmology. With four volumes published per year, each subspecialty is newly visited every 24 months, with a distinct focus on recent developments. By bridging the gap between original research and medical textbooks, the transfer of this developing knowledge into daily practice is greatly enhanced.

Eye -- Diseases -- Genetic aspects. --- Neuroophthalmology. --- Pediatric ophthalmology. --- Neuroophthalmology --- Pediatric ophthalmology --- Eye --- Strabismus --- Diagnosis --- Child --- Genetics --- Infant --- Age Groups --- Biology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Ocular Motility Disorders --- Persons --- Biological Science Disciplines --- Cranial Nerve Diseases --- Eye Diseases --- Named Groups --- Natural Science Disciplines --- Nervous System Diseases --- Diseases --- Disciplines and Occupations --- Ophthalmology & Optometry --- Medicine --- Health & Biological Sciences --- Genetic aspects --- Strabismus. --- Genetic aspects. --- Neuro-ophthalmology --- Heterotropia --- Squint --- Squinting --- Walleye (Ophthalmology) --- Medicine. --- Neurology. --- Ophthalmology. --- Pediatrics. --- Medicine & Public Health. --- Neurology --- Ophthalmology --- Movement disorders