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Death --- Mort --- Cardiac Death --- Determination of Death --- Near-Death Experience --- Death, Cardiac --- Thanatology --- Fatal Outcome --- Dying --- End of life --- Life --- Terminal care --- Terminally ill --- Philosophy --- End Of Life --- End-Of-Life --- Death. --- Mort. --- deaths.

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Today most people die gradually, from incremental illnesses, rather than from the heart attacks or fast-moving diseases that killed earlier generations. Given this new reality, the essays in Final Acts explore how we can make informed and caring end-of-life choices for ourselves and for those we loveùand what can happen without such planning. Contributors include patients, caretakers, physicians, journalists, lawyers, social workers, educators, hospital administrators, academics, psychologists, and a poet, and among them are ethicists, religious believers, and nonbelievers. Some write moving, personal accounts of "good" or 'bad" deaths; others examine the ethical, social, and political implications of slow dying. Essays consider death from natural causes, suicide, and aid-in-dying (assisted suicide). Writing in a style free of technical jargon, the contributors discuss documents that should be prepared (health proxy, do-not-resuscitate order, living will, power of attorney); decision-making (over medical interventions, life support, hospice and palliative care, aid-in-dying, treatment location, speaking for those who can no longer express their will); and the roles played by religion, custom, family, friends, caretakers, money, the medical establishment, and the government. For those who yearn for some measure of control over death, the essayists in Final Acts, from very different backgrounds and with different personal and professional experiences around death and dying, offer insight and hope.

Thanatology. --- Death. --- Death --- Dying --- End of life --- Life --- Terminal care --- Terminally ill --- Thanatology --- Cardiac Death --- Determination of Death --- End Of Life --- End-Of-Life --- Near-Death Experience --- Death, Cardiac --- Fatal Outcome --- Philosophy

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History of human medicine --- Death. --- Health. --- Disease. --- History of Medicine. --- Medicine, History --- Medicine --- Diseases --- Normalcy --- Normality --- Normalities --- Cardiac Death --- Determination of Death --- Near-Death Experience --- Death, Cardiac --- Thanatology --- Fatal Outcome --- history --- Death --- DISEASE --- Health --- history. --- Disease --- History. --- History Medicines --- Medicine Histories --- Medicines, History --- End Of Life --- End-Of-Life --- History of Medicine

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Euthanasia --- DEATH --- ATTITUDE TO DEATH --- Attitude to Death. --- Death. --- Euthanasia. --- #gsdb5 --- Euthanasia, Involuntary --- Involuntary Euthanasia --- Mercy Killing --- Killing, Mercy --- Killings, Mercy --- Mercy Killings --- Right to Die --- Suicide, Assisted --- Bioethical Issues --- Cardiac Death --- Determination of Death --- Near-Death Experience --- Death, Cardiac --- Thanatology --- Fatal Outcome --- Attitudes to Death --- Death, Attitude to --- Death, Attitudes to --- Death --- End Of Life --- End-Of-Life --- Attitude to Death --- gsdb5.

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With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future.

Sudden death. --- Sudden death --- Cardiac arrest --- Prevention. --- Pathophysiology. --- Death --- Mortality --- Causes --- Arrest, Cardiac --- Cardiopulmonary arrest --- Heart arrest --- Sudden cardiac death --- Heart --- Heart failure --- Diseases --- ventricular arrhythmia --- Inherited arrhythmia syndromes --- sudden death --- arrhythmia mechanisms --- Channelopathies --- ventricular tachycardia --- cardiac modelling --- Ventricular Fibrillation --- Atrial Fibrillation --- Brugada Syndrome