Choose an application
In 1990, scientists began working together on one of the largest biological research projects ever proposed. The project proposed to sequence the three billion nucleotides in the human genome. The Human Genome Project took 13 years and was completed in April 2003, at a cost of approximately three billion dollars. It was a major scientific achievement that forever changed the understanding of our own nature. The sequencing of the human genome was in many ways a triumph for technology as much as it was for science. From the Human Genome Project, powerful technologies have been developed (e.g., microarrays and next generation sequencing) and new branches of science have emerged (e.g., functional genomics and pharmacogenomics), paving new ways for advancing genomic research and medical applications of genomics in the 21st century. The investigations have provided new tests and drug targets, as well as insights into the basis of human development and diagnosis/treatment of cancer and several mysterious humans diseases. This genomic revolution is prompting a new era in medicine, which brings both challenges and opportunities. Parallel to the promising advances over the last decade, the study of the human genome has also revealed how complicated human biology is, and how much remains to be understood. The legacy of the understanding of our genome has just begun. To celebrate the 10th anniversary of the essential completion of the Human Genome Project, in April 2013 Genes launched this Special Issue, which highlights the recent scientific breakthroughs in human genomics, with a collection of papers written by authors who are leading experts in the field.
Human genome. --- Genomes --- Human chromosomes
Choose an application
The human genome is the complete set of human genetic information, stored as DNA sequences within the 23 chromosome pairs of the cell nucleus and in a small DNA molecule within the mitochondrion. In this publication, the authors present topical research in the study of the components, structural and functional disorders; and ethical issues of the human genome. Topics discussed include critical events in the pathobiology of cancer and the compilation of major biomarkers enabling improved diagnosis; and the evolution of human genome analysis and its impact on disease diagnosis and molecular diag
Human genome --- Human genetics. --- Human chromosomes. --- Chromosomes --- Human genetics --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Genomes --- Human chromosomes --- Analysis.
Choose an application
The fungi have been major players in the molecular revolution that has transformed biology. Because they can be manipulated as microorganisms, yeast and Neurospora provide information that is difficult to acquire with plants and animals, and experimental findings with fungi often throw light on corresponding processes in plants and animals. The filamentous fungus Neurospora crassa has become a valuable model organism because of its favorable features for genetic analysis and because of the vast store of information that has been acquired during 75 years of research. This compendium provides re
Neurospora. --- Neurospora --- Plant chromosomes. --- Chromosomes --- Plant cells and tissues --- Sordariaceae --- Genetics.
Choose an application
No detailed description available for "Comparative Karyology of Primates".
Neurophysiology. --- Karyotypes --- Chromosomes --- Chromosome abnormalities --- Cytotaxonomy --- Genetics --- Neurophysiology
Choose an application
Nutrition --- Human genome. --- Genomes --- Human chromosomes --- Genetics --- Genetic aspects.
Choose an application
Cytogenetics. --- Cytology --- Genetics --- Human genome. --- Genomes --- Human chromosomes
Choose an application
The application of molecular technology has greatly increased our understanding of the role of chromosomal change in plant evolution. This book addresses issues such as heterogeneity, chromosomal rearrangements within species and phenotypic consequences of chromosome doubling.
Plant Physiology --- Botany --- Earth & Environmental Sciences --- Plant chromosomes. --- Plants --- Evolution. --- Plant evolution --- Evolution (Biology) --- Chromosomes --- Plant cells and tissues --- Phylogeny
Choose an application
When examined carefully at the molecular level, the chromosome turns out to have created its own private world full of tricks, back door exits and novel solutions. This "folly" makes it an untamed innovator. Geneticists have been bewildered for decades. What kind of creature was actually the chromosome? Was it plastic, changing by innumerous rearrangements and mutations all the time; or was it a rigid structure which has preserved its basic organisation and functions since the dawn of the cell? It is this conflicting state that seems to be at the base of its "folly". Perplexed by this behavior
Chromosomes. --- Mutation (Biology) --- Genetics. --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Variation (Biology) --- Genetics --- Chromosome theory --- Cell nuclei --- Crossing over (Genetics) --- Cytotaxonomy --- Karyokinesis --- Linkage (Genetics)
Choose an application
This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as ""telomeres"" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled.
Telomere. --- Telomeres --- Chromosomes --- Life Sciences --- Genetics and Molecular Biology --- Karyology --- Biochemistry --- Microbial Genetics
Choose an application
Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information.* Provides detailed discussion of the genetic mechanisms that result in the ge
Cancer --- Genetic recombination. --- Genetic aspects. --- Recombination, Genetic --- Chromosomes --- Recombinant DNA --- Cancer genetics --- Cancer genes