Choose an application
Plants --- Cultivated
Choose an application
Plants --- Malvaceae.
Choose an application
Choose an application
Choose an application
Invasive plants --- Invasive plants --- Invasive plants --- Control --- Control --- Control
Choose an application
Invasive plants --- Invasive plants --- Invasive plants --- Control --- Control --- Control
Choose an application
""What Went Wrong?"" has revolutionized the way industry views safety. The new edition continues and extends the wisdom, innovations and strategies of previous editions, by introducing new material on recent incidents, and adding an extensive new section that shows how many accidents occur through simple miscommunications within the organization, and how straightforward changes in design can often remove or reduce opportunities for human errors. Kletz' approach to learning as deeply as possible from previous experiences is made yet more valuable in this new edition, which for the
Chemical plants --- Accidents. --- Chemical plants: accidents. --- accidents.
Choose an application
Choose an application
Cancer is a complex pathology in which several non-genetic factors such as hypoxia, inflammation and angiogenesis play a role in the disease progression. Although different anticancer modalities do exist, their use is often limited by important adverse effects. There is therefore a perpetual need to find new therapeutic molecules. The objective of this study was to characterize a potential anti-angiogenic activity from extracts of a plant named Schrankia leptocarpa, and if possible, to purify the active compound(s). Schrankia leptocarpa was selected because of its use as a treatment of diverse inflammatory pathologies in Benin. A screening test based on cytotoxicity measurements was used to determine the effect/dose relationship of extracts on different cell types. Quiescent and proliferating endothelial cells were used to reproduce the conditions of a healthy tissue and tumor vessels, respectively. The lack of cytotoxicity on healthy cells and an activity on tumor cells were chosen as additional filters to identify the most interesting extracts. Some experiments were also carried out under hypoxic conditions to mimic the tumor environment. Cytotoxic activity of a few extracts was identified both in proliferating endothelial cells and tumor cells. These extracts were also able to inhibit endothelial tube formation in an assay based on the capacity of endothelial cells to organize them into a network when cultured on extracellular matrix. Also, a slightly higher cytotoxicity of the extract was observed on endothelial cells maintained under hypoxic conditions. The dichloromethane extract was fractionated by liquid chromatography and fractions concentrating the activity could be isolated. The comparison of the LC-MS profile of the most active fraction with the chromatogram of known molecules indicated that besides lupeol which has a notorious antitumor activity, new molecules with an anti-angiogenic activity could be isolated from Schrankia leptocarpa Le cancer est une pathologie complexe dans laquelle interviennent divers facteurs tels que l’hypoxie, l’inflammation et l’angiogenèse. De plus en plus de traitements différents sont disponibles mais tous comportent des effets secondaires limitant souvent leur potentiel thérapeutique, d’où l’intérêt permanent de rechercher de nouvelles molécules. L’objectif de ce mémoire était de caractériser l’activité anti-angiogénique potentielle d’extraits d’une plante, le Schrankia leptocarpa, et le cas échéant d’entreprendre la purification du composé actif. Cette plante a été choisie pour son utilisation au Bénin dans le traitement de diverses pathologies à connotation inflammatoire. Un test de criblage basé sur la mise en évidence de la cytotoxicité a permis d’établir la relation dose /effet des extraits sur différents types cellulaires. Des cellules endothéliales quiescentes et proliférantes ont été utilisées afin de reproduire les conditions rencontrées respectivement dans un tissu sain et dans une tumeur sur des cellules tumorales ont constitué des filtres supplémentaires permettant d’identifier les extraits les plus intéressants. Certaines expériences ont également été réalisées en condition hypoxique de façon à mimer le microenvironnement tumoral. Une activité cytotoxique sur les cellules endothéliales proliférantes et tumorales a été identifiée sur certains extraits. Ces mêmes extraits se sont révélés capables d’inhiber la formation de tubes endothéliaux dans un test exploitant la capacité des cellules endothéliales à s’organiser en réseau lorsqu’elles sont cultivées sur une matrice extracellulaire. De plus, une légère augmentation de l’activité cytotoxique a été identifiée en condition hypoxique. Le sous-fractionnement par chromatographie liquide de l’extrait le plus actif a permis de démontrer que l’activité de celui-ci se concentrait dans certaines fractions. Le recours à la LC-MS et la confrontation aux profils de certaines molécules naturelles connues suggèrent qu’à côté du lupéol déjà identifié pour son activité anti-tumorale, des composés anti-angiogéniques nouveaux pourraient être isolés de l’extrait dichlorométhane du Schrankia leptocarpa.
Plants, Medicinal --- Plants, Medicinal --- Angiogenesis Inducing Agents
Choose an application
This classic of midwestern natural history is back in print with a new format and new photographs. Originally published in 1979, Wildflowers of Iowa Woodlands introduced many naturalists to the beauty and diversity of the native plants of the wooded communities that once covered more than 6 million acres of the state. Now redesigned with updated names and all-new images, this reliable field companion will introduce woodland wildflowers to a new generation of outdoor enthusiasts in the Upper Midwest. The species accounts are accompanied by brilliant full-page color photographs by Larry Stone,
Wild flowers --- Forest plants --- Plants, Useful