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This book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies. Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung. The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application. This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.

Lungs --- Lung --- Cardiopulmonary system --- Chest --- Respiratory organs --- Diseases --- Treatment. --- Stem cells. --- Respiratory organs—Diseases. --- Stem Cells. --- Pneumology/Respiratory System. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Malalties dels pulmons --- Cèl·lules mare --- Terapèutica --- Teràpia --- Tractament (Medicina) --- Tractament de les malalties --- Medicina clínica --- Al·lopatia (Terapèutica) --- Antipirètics --- Cateterisme --- Dietoteràpia --- Fisioteràpia --- Fórmules magistrals --- Hormonoteràpia --- Immunoteràpia --- Injeccions intraarticulars --- Intubació --- Ioga --- Logopèdia --- Medicina alternativa --- Nutrició --- Quimioteràpia --- Radiologia intervencionista --- Terapèutica dental --- Terapèutica fisiològica --- Teràpia genètica --- Teràpia intravenosa --- Teràpia respiratòria --- Terapèutica veterinària --- Tractament pal·liatiu --- Ús terapèutic --- Cèl·lules --- Cèl·lules mare embrionàries --- Malalties pulmonars --- Pneumopaties --- Bronquitis --- Displàsia broncopulmonar --- Fibrosi pulmonar --- Fibrosi quística --- Insuficiència respiratòria --- Legionel·losi --- Malalties pulmonars obstructives cròniques --- Pneumònia --- Pneumotòrax --- Malalties del pulmó --- Stem Cell Research. --- Lung Diseases. --- Disease, Pulmonary --- Diseases, Pulmonary --- Pulmonary Disease --- Pulmonary Diseases --- Disease, Lung --- Diseases, Lung --- Lung Disease --- Adult Stem Cell Research --- Embryonic Stem Cell Research --- Research, Stem Cell --- Researchs, Stem Cell --- Stem Cell Researchs --- Stem Cells --- Embryo Research --- Colony-Forming Unit --- Colony-Forming Units --- Mother Cells --- Progenitor Cells --- Cell, Mother --- Cell, Progenitor --- Cell, Stem --- Cells, Mother --- Cells, Progenitor --- Cells, Stem --- Colony Forming Unit --- Colony Forming Units --- Mother Cell --- Progenitor Cell --- Stem Cell --- Cell Self Renewal --- Stem Cell Research