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Stress of either a psychological or a physical nature can activate and/or paralyse humans’ innate or adaptive immunity. However, adequate immunity is crucial to the maintenance of health on earth and in space. During space flight, human physiology and health are challenged by complex environmental stressors (confinement, gravitation, oxygen tension, radiation) which might be at their most pronounced during lunar or interplanetary missions. This book adopts an interdisciplinary approach in seeking to identify the impact of living conditions in space on the adaptation of the immune system. While other publications have addressed the physiological changes that occur during space flight, to the authors’ knowledge this is the first book specifically to analyze the complex interaction of living conditions in space, the immune system, and astronauts’ health. It is explained how such analysis of the consequences of stress for the immune system may help in preventing, diagnosing, and counteracting immune-related alterations in health on earth as well as in space.

Immunity. --- Immunity -- physiology. --- Space Flight. --- Space medicine. --- Stress (Physiology). --- Stress, Physiological -- physiology. --- Stress (Physiology) --- Physiological Processes --- Immune System Phenomena --- Biological Science Disciplines --- Aviation --- Physiological Phenomena --- Phenomena and Processes --- Natural Science Disciplines --- Transportation --- Disciplines and Occupations --- Technology, Industry, and Agriculture --- Technology, Industry, Agriculture --- Physiology --- Immunity --- Space Flight --- Stress, Physiological --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Transportation Medicine & Physiology --- Immune system --- Research. --- Immunological system --- Physiological stress --- Tension (Physiology) --- Medicine. --- Human physiology. --- Immunology. --- Neurosciences. --- Biomedicine. --- Human Physiology. --- Medicine/Public Health, general. --- Adaptation (Biology) --- Anatomy --- Immunology --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Human body --- Health Workforce

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Immunology. Immunopathology --- Human physiology --- Hygiene. Public health. Protection --- Neuropathology --- immunologie --- neurologie --- gezondheidszorg --- fysiologie

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This book gives insight into the mechanism of the immune system and the influence of the environment on earth. Further, the book explains the changes that occur in our immune system in the absence of gravity and their fundamental consequences. Several limiting factors for human health and performance in microgravity have been clearly identified as an unacceptable risk for long-term and interplanetary flights. Serious concerns arose whether spaceflight-associated immune system dysfunction ultimately precludes the expansion of human presence beyond Earth's orbit. The immune system has undergone many evolutionary steps to cope with a new and changing environment, but `space` has not been evolutionary experienced before. Through endocrine orchestration of cell functions, cell to cell communications and intracellular mechanisms the human body and his immune system have an enormous capacity to adapt and react to altered environmental conditions. Thus, the special sensitivity to altered gravity renders the immune system an ideal biological model system to understand if and how gravity on Earth is required for the normal function of cells and cellular networks. It is one of the most fundamental challenges to find out, if our organism and our cellular machinery are able to live and to adequately perform without the gravity field of Earth. The book is written for immunologists and researchers in human physiology under normal and stressfull conditions.

Space research --- Astronomy --- Immunology. Immunopathology --- Human physiology --- Pathological biochemistry --- Human medicine --- Applied physical engineering --- Air traffic --- immunologie --- medische biochemie --- astronauten --- biochemie --- biomedische wetenschappen --- fysiologie --- engineering --- luchtvaart --- ruimtevaart

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This book gives insight into the mechanism of the immune system and the influence of the environment on earth. Further, the book explains the changes that occur in our immune system in the absence of gravity and their fundamental consequences. Several limiting factors for human health and performance in microgravity have been clearly identified as an unacceptable risk for long-term and interplanetary flights. Serious concerns arose whether spaceflight-associated immune system dysfunction ultimately precludes the expansion of human presence beyond Earth's orbit. The immune system has undergone many evolutionary steps to cope with a new and changing environment, but `space` has not been evolutionary experienced before. Through endocrine orchestration of cell functions, cell to cell communications and intracellular mechanisms the human body and his immune system have an enormous capacity to adapt and react to altered environmental conditions. Thus, the special sensitivity to altered gravity renders the immune system an ideal biological model system to understand if and how gravity on Earth is required for the normal function of cells and cellular networks. It is one of the most fundamental challenges to find out, if our organism and our cellular machinery are able to live and to adequately perform without the gravity field of Earth. The book is written for immunologists and researchers in human physiology under normal and stressfull conditions.

Human physiology. --- Immunology. --- Aerospace engineering. --- Astronautics. --- Human Physiology. --- Immunology. --- Aerospace Technology and Astronautics.

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Space research --- Astronomy --- Immunology. Immunopathology --- Human physiology --- Neuropathology --- Human medicine --- Applied physical engineering --- Air traffic --- immunologie --- neurologie --- geneeskunde --- fysiologie --- engineering --- luchtvaart --- ruimtevaart