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This series presents highly cited contributions first published in the journal Current Protein and Peptide Science. Each volume highlights a number of important topics in current research in the field of protein and peptide chemistry and molecular biology, including membrane proteins and their interactions with ligands, computational methods, and proteins in disease and biotechnology.

Proteins. --- Peptides. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Organic compounds --- Amino acids

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HIV PROTEASE --- HIV PROTEASE INHIBITORS --- HEPATITIS C-LIKE VIRUSES --- HERPESVIRIDAE --- PICORNAVIRIDAE --- CANDIDA --- MALARIA --- CHAGAS DISEASE --- PLANT VIRUSES --- INFLUENZA --- PARAMYXOVIRUS --- ANALYSIS

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Peptide synthesis has emerged as one of the most powerful tools in biochemical, pharmacological, immunological, and biophysical laboratories. Recent improvements include general solid-phase methodology, new protecting groups, and automated equipment. These advances have allowed the facile synthesis of increasingly more complex p- tides. Many of these new and improved methods for the synthesis of peptides and peptide-related substances have been reported in various publications, but never compiled in a convenient handbook. Like other volumes in this series, Peptide Synthesis Protocols concentrates on the practical aspects of these procedures, providing the researcher with detailed descriptions and helpful tips about potential problems. This volume is not intended to serve as a basic guide to standard Merrifie- type solid-phase strategy, but rather to provide the researcher with some of the most recent applications in the field of peptide science. A companion volume, Peptide Analysis Protocols, will detail methodology for the charaterization of new synthetic peptides. Development of new methods and applications has continued actively even as this volume was in preparation. Owing to the number of contributors to this volume, it was necessary to establish a cutoff for publication purposes. We feel that all of the protocols presented are timely and up-to-date. Several promising new strategies, such as allyloxycarbonyl-based syntheses, were being developed at the time this volume was in the editing stages and will be included in future editions.

chemical synthesis --- chemical synthesis. --- Chemical synthesis. --- Life sciences. --- Biochemistry. --- Life Sciences. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Biosciences --- Sciences, Life --- Science --- Composition --- Peptides --- Synthesis --- Organic compounds --- Amino acids --- Laboratory manuals. --- Laboratory manuals