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This book provides an up-to-date coverage of selected topics in the area of nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics. In addition to some of the traditionally covered topics, we have included some areas that receive less attention in similar volumes, for example chapters focusing on damage to nucleic acids by halogenating and nitrating species, gene-specific damage, telomere shortening and damage to promoter regions. Through this approach, we recognize additionally the importance of nucleic acid damage beyond mutation and in pathological conditions other than carcinogenesis. The primary audience for the book would be research scientists and advanced postgraduate students, the book may also be of interest to clinicians with strong research interests. We would expect readers to come away from this book with a greater appreciation of the topic, particularly appraising the reader of areas that may not necessarily have been covered in such a volume before.

Life Sciences. --- Biochemistry, general. --- Life sciences. --- Biochemistry. --- Sciences de la vie --- Biochimie --- Antioxidants -- therapeutic use. --- Chemical mutagenesis. --- DNA Damage. --- DNA Repair Enzymes. --- DNA repair. --- Nucleic acids -- Oxidation. --- Oxidative Stress. --- Nucleic acids --- DNA repair --- Chemical mutagenesis --- DNA Repair --- Oxidative Stress --- Antioxidants --- DNA Damage --- DNA Repair Enzymes --- Stress, Physiological --- Genetic Processes --- Biochemical Processes --- Metabolism --- Protective Agents --- Enzymes --- Molecular Mechanisms of Pharmacological Action --- Physiological Processes --- Specialty Uses of Chemicals --- Genetic Phenomena --- Chemical Processes --- Physiological Effects of Drugs --- Pharmacologic Actions --- Biochemical Phenomena --- Metabolic Phenomena --- Enzymes and Coenzymes --- Phenomena and Processes --- Chemical Actions and Uses --- Chemicals and Drugs --- Physiological Phenomena --- Chemical Phenomena --- Biology - General --- Biochemistry --- Animal Biochemistry --- Human Anatomy & Physiology --- Chemistry --- Biology --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Oxidation --- Oxidation. --- Deoxyribonucleic acid repair --- Repair, DNA --- Repair mechanisms in DNA --- Polynucleotides --- Biosciences --- Sciences, Life --- Science --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Composition --- Genetic toxicology --- Mutagenesis --- Biochemical genetics --- Antimutagens --- Biomolecules