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Welche Veränderungen gingen mit der römischen Herrschaft am unteren Lauf des Rheins einher? Welche Lebensbereiche blieben von der Romanisierung unberührt? Welche Kontinuitäten, welche Brüche lassen sich in Politik, Gesellschaft, Wirtschaft und Kultur der Germania inferior feststellen? Geschichtliche Übergänge wie die Anfangs- und die Endphase der römischen Herrschaft sind für die historischen Wissenschaften Phänomene von besonderer Aussagekraft: So klein die Provinz auch war, weist die Germania inferior doch keine einheitliche Entwicklung auf. Für Stadt und Land, Nord und Süd und schließlich für die Bereiche des politischen, gesellschaftlichen, wirtschaftlichen und kulturellen Lebens ergeben sich verschiedene Befunde. Im vorliegenden Band bemühen sich niederländische und deutsche Archäologen und Althistoriker um eine differenzierte Beantwortung der Kontinuitätsfrage. What changes coincided with Roman rule on the lower reaches of the Rhine? What aspects of life remained untouched by Romanization? What continuities and discontinuities can be identified in politics, society, the economy, and culture of Germania Inferior? Historical transitions such as the early and final phase of Roman rule are especially illuminating phenomena for the historical sciences. As small as Germania Inferior was, the province did not develop uniformly. Differences between urban and rural environments, between northern and southern regions, and between political, social, economic, and-cultural aspects of life have been found. The Dutch and German archaeologists and experts on ancient history who have contributed to this volume offer discriminating answers to the question of continuity.

History of civilization --- Netherlands --- Pays-Bas --- History --- Congresses --- Civilization --- Histoire --- Congrès --- Civilisation --- Congrès --- To 1384 --- Roman influences --- Roman influences. --- HISTORY / General. --- The Netherlands --- Países Baixos --- Holland --- Spanish Netherlands --- Pays-Bas espagnols --- Austrian Netherlands --- Pays-Bas autrichiens --- Oostenrijkse Nederlanden --- Southern Netherlands --- Pays-Bas méridionaux --- Zuidelijke Nederlanden --- Niderlandy --- Belanda --- Nederland --- Koninkrijk der Nederlanden --- Reino dos Países Baixos --- Royaume des Pays-Bas --- Kingdom of the Netherlands --- Países Bajos --- Holanda --- Nederlân --- Hulanda --- Beulanda --- Niderland --- Niderlande --- هولندا --- مملكة هولندا --- Mamlakat Hūlandā --- Olanda --- Payis-Bâs --- Países Baxos --- Aynacha Jach'a Markanaka --- Nirlan --- Niderland Krallığı --- Kē-tē-kok --- Landa --- Kerajaan Landa --- Нидерландтар --- Niderlandtar --- Нидерландтар Короллеге --- Niderlandtar Korollege --- Нідэрланды --- Каралеўства Нідэрланды --- Karaleŭstva Nidėrlandy --- Nederlands --- Niadaland --- Holandija --- Kraljevina Holandija --- Izelvroioù --- Нидерландия --- Niderlandii︠a︡ --- Кралство Нидерландия --- Kralstvo Niderlandii︠a︡ --- Països Baixos --- Нидерландсем --- Niderlandsem --- Нидерландсен Патшалăхĕ --- Niderlandsen Patshalăkhĕ --- Nizozemsko --- Paesi Bassi --- Regnu di i Paesi Bassi --- Iseldiroedd --- Nederlandene --- Niederlande --- Kéyah Wóyahgo Siʼánígíí --- Nižozemska --- Kralojstwo Nederlandow --- Madalmaad --- Ολλανδία --- Ollandia --- Hollandia --- Κάτω Χώρες --- Katō Chōres --- Βασίλειο των Κάτω Χωρών --- Vasileio tōn Katō Chōrōn --- Nederlando --- Reĝlando Nederlando --- Paisis Bajus --- Herbehereak --- Herbehereetako Erresumaren --- هلند --- Huland --- Niðurlond --- Háland --- Paîs Bas --- Neerlande --- Ísiltír --- Ríocht na hÍsiltíre --- Çheer Injil --- Çheer y Vagheragh --- Reeriaght ny Çheer Injil --- Tìrean Ìsle --- Hò-làn --- Недерлендин Нутг --- Nederlendin Nutg --- 네덜란드 --- Nedŏllandŭ --- Hōlani --- Nederlandia --- Pais Basse --- Regno del Paises Basse --- Нидерландтæ --- Niderlandtæ --- Нидерландты Къаролад --- Niderlandty Kʺarolad --- Konungsríkið Holland --- הולנד --- Holand --- ממלכת ארצות השפלה --- Mamlekhet Artsot ha-Shefelah --- Walanda --- Hollandi --- Нидерландла --- Niderlandla --- Нидерландланы Королевствосу --- Niderlandlany Korolevstvosu --- Néderlandzkô --- Нидерланд --- Iseldiryow --- Ubuholandi --- Ubuhorandi --- Nederilande --- Нидерланддар --- Niderlanddar --- Uholanzi --- Ufalme wa Nchi za Chini --- Нидерландъяс --- Niderlandʺi︠a︡s --- Нидерландъяс Корольув --- Niderlandʺi︠a︡s Korolʹuv --- Peyiba --- Holenda --- Keyatiya Nederlandan --- Payises Bashos --- פאייסיס באשוס --- Nīderlandeja --- Batavia --- Regni Nederlandiarum --- Nīderlandes Karaliste --- Nyderlandai --- Nyderlandų Karalystė --- Paixi Basci --- Paes Bass --- Ulanda --- Holland Királyság --- Keninkryk fan 'e Nederlannen --- Reino di Hulanda --- Холандија --- Кралство Холандија --- Kralstvo Holandija --- Pajjiżi l-Baxxi --- Hōrana --- Недерлатт --- Nederlatt --- Оцязорксши Недерлатт --- Ot︠s︡i︠a︡zorksshi Nederlatt --- Нидерландын Вант Улс --- Niderlandyn Vant Uls --- Tlanitlālpan --- Huēyitlahtohcāyōtl in Tlanitlālpan --- Eben Eyong --- Nederlaand --- オランダ --- Oranda --- オランダ王国 --- Oranda Ōkoku --- Ulanna --- Nethiland --- Nederlande --- Holandska --- Holland (Kingdom) --- Batavian Republic --- United Provinces of the Netherlands

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Brigands and robbers --- Robbery --- Bandits et brigands --- Vol qualifié --- History --- Histoire --- Insurgency --- Political violence --- 322.420937 --- Violence --- Political crimes and offenses --- Terrorism --- Insurgent attacks --- Rebellions --- Civil war --- Revolutions --- Government, Resistance to --- Internal security --- Bandits --- Banditti --- Highwaymen --- Robbers --- Thieves --- Outlaws --- Rogues and vagabonds --- Social science Relation of the state to groups and their members Revolutionary and subversive groups Ancient Italy

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Netherlands --- Netherlands --- History --- Civilization --- Roman influences.

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This volume aims at providing a selection of the most effective and widely employed protocols used in the Ewing sarcoma field. Chapters are divided into five sections detailing the molecular biology techniques used to analyze Ewing sarcoma including tissue preservation and methods used in morpho-molecular diagnostics and routine immune-histological analysis. Additional wet-lab protocols comprise in vitro techniques including re-expression and functional analyses of target genes together with in vivo tools and models such as patient-derived xenografts (PDX) and orthotopic xenografts for metastasis assessment in Ewing sarcoma. A full section on bioinformatic approaches to Ewing sarcoma covering ChIPseq, epigenetic and systems biology analyses finalizes this volume. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and clearly written, Ewing sarcoma: Methods and Protocols aims to provide methods to further the study of Ewing sarcoma and bring researchers one step forward in the quest to fight this devastating disease.

Cancer. --- Cancer Biology. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors

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Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses such as the “Pediatric Cancer Translational Genomics” conference (Phoenix, Arizona, 2012), the ESF-EMBO workshop on “Molecular Biology and Innovative Therapies in Sarcomas” (Pultusk, Poland, 2012), and the AACR special meeting on “Pediatric Cancer at the Crossroads – Translating Discovery into Improved Outcomes” (San Diego, California, 2013) further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and that it would have great potential to receive numerous contributions of outstanding experts of the field. The proposed Frontiers Research Topic shall provide a platform for active and interdisciplinary discussion, summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and offer new perspectives of how to further promote and accelerate the translational process. We welcome high-quality original research articles, brief reports, as well as opinion, hypothesis, and review articles, and especially encourage submissions from early-career scientists.

Oncology --- Cancer in children --- Research. --- Treatment. --- targeted therapy --- Translational research --- Ewing sarcoma --- Sarcoma --- pediatric oncology --- Osteosarcoma --- Immunotherapy --- bone tumor --- Rhabdomyosarcoma --- epithelioid sarcoma