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The past decade has witnessed significant progress in the diagnosis and treatment of nasopharyngeal cancer. Radiation therapy, used with curative intent, has undergone important technological advances, and combined chemotherapy and radiation has also become an established option. As a result, outcomes among patients with localized disease have improved markedly, with higher overall survival, better locoregional disease control, less treatment-induced toxicity, and better quality of life. However, most of the developments that have taken place are complex, and often not fully understood by physicians in general oncology practice without specialization in the treatment of head and neck cancer. Against this background, Nasopharyngeal Cancer - Multidisciplinary Management aims to provide a comprehensive account of the current state of knowledge of nasopharyngeal cancer and its multidisciplinary management. The first ten chapters contain essential information on subjects such as epidemiology, pathogenesis, molecular biology, pathology, and the use of imaging in diagnosis and staging. Subsequent chapters examine in depth the various treatment options and explain combinations in a range of settings. Detailed attention is given to the roles of concurrent, adjuvant, and neoadjuvant chemotherapy and advanced radiotherapy techniques. Further chapters then explore surgical options, follow-up, treatment of metastatic disease, treatment-related and complications and nasopharyngeal cancer in children. This is an important book that meets an urgent need and will prove essential reading for the oncology community worldwide.

Nasopharynx --Cancer. --- Nasopharynx --- Diagnosis --- Nasopharyngeal Neoplasms --- Nasopharyngeal Diseases --- Pharyngeal Neoplasms --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharyngeal Diseases --- Otorhinolaryngologic Neoplasms --- Otorhinolaryngologic Diseases --- Stomatognathic Diseases --- Head and Neck Neoplasms --- Diseases --- Neoplasms by Site --- Neoplasms --- Radiology, MRI, Ultrasonography & Medical Physics --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer --- Head --- Tumors. --- Cancer. --- Medicine. --- Radiology. --- Radiotherapy. --- Oncology. --- Otorhinolaryngology. --- Medicine & Public Health. --- Imaging / Radiology.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The past decade has witnessed significant progress in the diagnosis and treatment of nasopharyngeal cancer. Radiation therapy, used with curative intent, has undergone important technological advances, and combined chemotherapy and radiation has also become an established option. As a result, outcomes among patients with localized disease have improved markedly, with higher overall survival, better locoregional disease control, less treatment-induced toxicity, and better quality of life. However, most of the developments that have taken place are complex, and often not fully understood by physicians in general oncology practice without specialization in the treatment of head and neck cancer. Against this background, Nasopharyngeal Cancer - Multidisciplinary Management aims to provide a comprehensive account of the current state of knowledge of nasopharyngeal cancer and its multidisciplinary management. The first ten chapters contain essential information on subjects such as epidemiology, pathogenesis, molecular biology, pathology, and the use of imaging in diagnosis and staging. Subsequent chapters examine in depth the various treatment options and explain combinations in a range of settings. Detailed attention is given to the roles of concurrent, adjuvant, and neoadjuvant chemotherapy and advanced radiotherapy techniques. Further chapters then explore surgical options, follow-up, treatment of metastatic disease, treatment-related and complications and nasopharyngeal cancer in children. This is an important book that meets an urgent need and will prove essential reading for the oncology community worldwide.

Radiotherapy. Isotope therapy --- Oncology. Neoplasms --- Physical methods for diagnosis --- Otorhinolaryngology --- radiotherapie --- oncologie --- otorinolaryngologie --- radiologie --- medische beeldvorming

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In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new treatment usually many years pass before it can be implemented in the routine care. During that time, already new interventions emerge, new drugs appear on the market, technical & physical innovations are being implemented, novel biology driven concepts are translated into clinical approaches while we are still investigating the ones from years ago. Another problem is associated with molecular diagnostics and the growing amount of tumor specific biomarkers which allows for a better stratification of patient subgroups. On the other side, this may result in a much longer time for patient recruiting and consequently in larger multicenter trials. Moreover, all of the relevant data must be readily available for treatment decision making, treatment as well as follow-up, and ultimately for trial evaluation. This challenges even more for agreed standards in data acquisition, quality and management. How could we change the way currently clinical trials are performed in a way they are safe and ethically justifiable and speed up the initiation process, so we can provide new and better treatments faster for our patients? Further, while we rely on various quantitative information handling distributed, large heterogeneous amounts of data efficiently is very important. Thus data management becomes a strong focus. A good infrastructure helps to plan, tailor and conduct clinical trials in a way they are easy and quickly analyzable. In this research topic we want to discuss new ideas for intelligent trial designs and concepts for data management.

Cancer --- Oncology, Experimental. --- Radiotherapy --- Data processing. --- Study Management --- Clinical trials --- Data Collection --- Radiation Oncology --- Clinical Study design