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A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena.Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons.Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.

Cellular signal transduction. --- Cellular control mechanisms. --- Cell regulation --- Biological control systems --- Cell metabolism --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Alexander Gann. --- Bohr effect. --- Bruce Mayer. --- Cell Signaling. --- Genes and Signals. --- MWC enzymes. --- Mark Ptashne. --- Michaelis-Menten Enzymes. --- Tony Pawson. --- Wendell Lim. --- allosterome. --- bacterial aerotaxis. --- cyclic nucleotide gated channels. --- enzyme phenomenology. --- gene expression. --- genome packing. --- glycolosis. --- ligand-receptor binding. --- logic gates. --- membrane receptors. --- nucleosomes. --- phoshofructokinase. --- signal transduction.

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La 4e de couverture indique : "Le monde de la cellule, incroyablement encombré mais extraordinairement actif, n'a rien de comparable à notre expérience quotidienne. Un regard quantitatif permet de mieux comprendre l'organisation dynamique de la cellule. Ce livre explore les grandeurs caractéristiques de la biologie cellulaire : la taille, les concentrations, l'énergie, la durée et l'information aux différentes échelles, de la molécule à la population cellulaire. Pour cela, il rassemble les données issues de travaux scientifiques récents, avec le souci d'établir des relations entre les différents organismes-modèles. Il s'appuie ensuite sur cette classification pour examiner la signification physiologique de ces données, dans un dialogue permanent entre mesures expérimentales, interprétation et prédictions théoriques. Le lecteur pourra ainsi acquérir une intuition profonde des processus qui animent la cellule-et découvrir de nouvelles facettes de ce monde microscopique. Cet ouvrage est destiné aux étudiants de licence en sciences de la vie, et constitue un support pédagogique pour les enseignants."

Cytology. --- Molecular biology --- Biometry --- Cytologie --- Cytologie moléculaire --- Biologie moléculaire --- Biométrie. --- Mesure. --- Molecular biology. --- Biometry.

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General biophysics --- Biophysics --- Cytology --- Cell Biology --- Cells --- ultrastructure --- Cellule --- cells --- Biologie moléculaire --- Molecular biology --- Numération cellulaire --- Cell counting --- Modèle --- Models --- Structure cellulaire --- cell structure --- Taxis --- Cinèse --- Kinesis --- Cycle cellulaire --- Différenciation cellulaire --- Cell differentiation --- Membrane cellulaire --- cell membranes --- Cytologie --- cytology --- Cells - ultrastructure

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Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics for undergraduate or graduate students. It maps the huge and complex landscape of cell and molecular biology from the distinct perspective of physical biology. As a key organizing principle, the proximity of topics is based on the physical concepts that

Biophysics. --- Biological physics --- Biology --- Medical sciences --- Physics