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The LNCS journal Transactions on Computational Systems Biology is devoted to inter- and multidisciplinary research in the fields of computer science and life sciences and supports a paradigmatic shift in the techniques from computer and information science to cope with the new challenges arising from the systems oriented point of view of biological phenomena. The six papers selected for this special issue are: Bio-inspired Network-Centric Operation and Control for Sensor/Actuator Networks; A Computationally Fast and Parametric Model to Estimate Protein-Ligand Docking Time for Stochastic Event Based Simulation; Equation-Based Congestion Control in the Internet Biologic Environment; Computational Thinking in Biology; End-to-End Information Management for Systems Biology; and a corrected version of: On Differentiation and Homeostatic Behaviours of Boolean Dynamical Systems.

Molecular biology --- Bioinformatics. --- Proteomics. --- Biologie moléculaire --- Bio-informatique --- Protéomique --- Data processing. --- Informatique --- Bioinformatics --- Proteomics --- Systems Biology --- Computational Biology --- Biochemistry --- Genomics --- Biology --- Biological Science Disciplines --- Chemistry --- Genetics --- Natural Science Disciplines --- Disciplines and Occupations --- Biophysics --- Biology - General --- Computer Science --- Engineering & Applied Sciences --- Health & Biological Sciences --- Data processing --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Bio-Informatics --- Biology, Computational --- Computational Molecular Biology --- Molecular Biology, Computational --- Bio Informatics --- Bio-Informatic --- Bioinformatic --- Biologies, Computational Molecular --- Biology, Computational Molecular --- Computational Molecular Biologies --- Molecular Biologies, Computational --- Biology, Systems --- Bio-informatics --- Biological informatics --- Molecular biochemistry --- Molecular biophysics --- Computer science. --- Computers. --- Algorithms. --- Mathematical logic. --- Computer Science. --- Computation by Abstract Devices. --- Mathematical Logic and Formal Languages. --- Algorithm Analysis and Problem Complexity. --- Information science --- Computational biology --- Systems biology --- Algebra of logic --- Logic, Universal --- Mathematical logic --- Symbolic and mathematical logic --- Symbolic logic --- Mathematics --- Algebra, Abstract --- Metamathematics --- Set theory --- Syllogism --- Algorism --- Algebra --- Arithmetic --- Automatic computers --- Automatic data processors --- Computer hardware --- Computing machines (Computers) --- Electronic brains --- Electronic calculating-machines --- Electronic computers --- Hardware, Computer --- Computer systems --- Cybernetics --- Machine theory --- Calculators --- Cyberspace --- Informatics --- Science --- Foundations --- Computer software. --- Software, Computer --- Proteins --- Biomolecules

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The LNCS journal Transactions on Computational Systems Biology is devoted to inter- and multidisciplinary research in the fields of computer science and life sciences and supports a paradigmatic shift in the techniques from computer and information science to cope with the new challenges arising from the systems oriented point of view of biological phenomena. This special issue of the journal focuses on the topic of modeling methodologies. It starts with a position paper by the guest editors, entitled Biomodel Engineering - from Structure to Behavior, which is followed by the technical contributions covering a broad range of modeling methodologies. Two papers focus on new modeling languages, and these are followed by an article presenting a case study demonstrating the value of the qualitative network approach. With the remaining three contributions, the special issue leaves the area of qualitative modeling, to move toward quantitative programming with the BlenX language and the application of more theoretical process calculi.

Computational biology --- Computer simulation --- Systems biology --- Computer Simulation --- Computational Biology --- Systems Biology --- Computing Methodologies --- Biology --- Information Science --- Biological Science Disciplines --- Natural Science Disciplines --- Disciplines and Occupations --- Biology - General --- Health & Biological Sciences --- Bioinformatics --- Computer science. --- Computers. --- Algorithms. --- Mathematical statistics. --- Artificial intelligence. --- Computer simulation. --- Bioinformatics. --- Computer Science. --- Computational Biology/Bioinformatics. --- Simulation and Modeling. --- Computation by Abstract Devices. --- Artificial Intelligence (incl. Robotics). --- Algorithm Analysis and Problem Complexity. --- Probability and Statistics in Computer Science. --- Bio-informatics --- Biological informatics --- Information science --- Computer modeling --- Computer models --- Modeling, Computer --- Models, Computer --- Simulation, Computer --- Electromechanical analogies --- Mathematical models --- Simulation methods --- Model-integrated computing --- AI (Artificial intelligence) --- Artificial thinking --- Electronic brains --- Intellectronics --- Intelligence, Artificial --- Intelligent machines --- Machine intelligence --- Thinking, Artificial --- Bionics --- Cognitive science --- Digital computer simulation --- Electronic data processing --- Logic machines --- Machine theory --- Self-organizing systems --- Fifth generation computers --- Neural computers --- Algorism --- Algebra --- Arithmetic --- Mathematics --- Statistical inference --- Statistics, Mathematical --- Statistics --- Probabilities --- Sampling (Statistics) --- Automatic computers --- Automatic data processors --- Computer hardware --- Computing machines (Computers) --- Electronic calculating-machines --- Electronic computers --- Hardware, Computer --- Computer systems --- Cybernetics --- Calculators --- Cyberspace --- Informatics --- Science --- Data processing --- Foundations --- Statistical methods --- Biological systems --- Molecular biology --- Computer software. --- Artificial Intelligence. --- Software, Computer

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Thisisthe?rstissueofanewjournaloftheLNCSjournalsubline.Theaimofthe journal is to encourage inter- and multidisciplinary research in the ?elds of c- puter science and life sciences. The recent paradigmatic shift in biology towards a system view of biological phenomena requires a corresponding paradigmatic shift in the techniques from computer science that can face the new challenges. Classical tools usually used in bioinformatics are no longer up to date and new ideas are needed. The convergence of sciences and technologies we are experiencing these days is changing the classical terms of reference for research activities. In fact clear distinctions between disciplines no longer exist because advances in one ?eld permit advances in others and vice versa, thus establishing a positive feedback loop between sciences. The potential impact of the convergence of sciences and technologies is so huge that we must consider how to control and correctly drive our future activities. International and national funding agencies are looking at interdisciplinary research as a key issue for the coming years, especially in the intersection of life sciences and information technology. To speed up this process, we surely need to establish relationships between researchers of di?erent communities and to de?ne a common language that will allow them to exchange ideas and - sults. Furthermore, expectations of di?erent communities can be merged only by running activities like common projects and experiences. TheTransactionsonComputationalSystemsBiologycouldbeagoodforumto helplifescientistsandcomputerscientiststodiscusstogethertheircommongoals.

Molecular biology --- Bioinformatics --- Proteomics --- Data processing --- Molecular Biology --- Science

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Mathematical logic --- Complex analysis --- Biomathematics. Biometry. Biostatistics --- Computer science --- complexe analyse (wiskunde) --- bio-informatica --- informatica --- biometrie --- wiskunde --- logica

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Thisisthe?rstissueofanewjournaloftheLNCSjournalsubline.Theaimofthe journal is to encourage inter- and multidisciplinary research in the ?elds of c- puter science and life sciences. The recent paradigmatic shift in biology towards a system view of biological phenomena requires a corresponding paradigmatic shift in the techniques from computer science that can face the new challenges. Classical tools usually used in bioinformatics are no longer up to date and new ideas are needed. The convergence of sciences and technologies we are experiencing these days is changing the classical terms of reference for research activities. In fact clear distinctions between disciplines no longer exist because advances in one ?eld permit advances in others and vice versa, thus establishing a positive feedback loop between sciences. The potential impact of the convergence of sciences and technologies is so huge that we must consider how to control and correctly drive our future activities. International and national funding agencies are looking at interdisciplinary research as a key issue for the coming years, especially in the intersection of life sciences and information technology. To speed up this process, we surely need to establish relationships between researchers of di?erent communities and to de?ne a common language that will allow them to exchange ideas and - sults. Furthermore, expectations of di?erent communities can be merged only by running activities like common projects and experiences. TheTransactionsonComputationalSystemsBiologycouldbeagoodforumto helplifescientistsandcomputerscientiststodiscusstogethertheircommongoals.

Molecular biology --- Bioinformatics --- Proteomics --- Data processing --- Molecular Biology --- Science