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577.323 --- 577.3 --- DNA --- -Macromolecules --- -Statistical mechanics --- #KVIV:BB --- Mechanics --- Mechanics, Analytic --- Quantum statistics --- Statistical physics --- Thermodynamics --- Molecules --- Supramolecular chemistry --- Deoxyribonucleic acid --- Desoxyribonucleic acid --- Thymonucleic acid --- TNA (Nucleic acid) --- Deoxyribose --- Nucleic acids --- Genes --- Physics and physical chemistry of nucleic acids --- Physical and physicochemical bases of life. Biophysics. Biophysical chemistry in general --- Stability --- -Statistical methods --- Macromolecules --- Statistical mechanics. --- Statistical methods. --- 577.3 Physical and physicochemical bases of life. Biophysics. Biophysical chemistry in general --- 577.323 Physics and physical chemistry of nucleic acids --- Statistical mechanics --- Stability&delete& --- Statistical methods
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This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly co-operative transitions needed to explain helix melting. A new theoretical approach for executing macromolecule calculations is developed. In particular, the author devises a method for describing chemical bond disruption in these large systems, which are then used to determine when the helix melts and how drugs can dissociate from the helix. Melting temperatures are found to be in excellent agreement with experimental observations. The book will be of interest to biomolecular dynamics researchers, especially to graduate students in biological physics, theoretical chemistry and molecular biology.
DNA --- Macromolecules --- Statistical mechanics. --- Stability --- Statistical methods.
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