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In the pursuit of technological advancement in the field of biotechnology and pharmaceutical industries to counteract health issues, bacterial infections remain a major cause of morbidity and mortality. The ability of bacterial pathogens to form biofilms further agglomerates the situation by showing resistance to conventional antibiotics. To overcome this serious issue, bioactive metabolites and other natural products were exploited to combat bacterial infections and biofilm-related health consequences. Natural products exhibited promising results in vitro, however; their efficacy in in vivo conditions remain obscured due to their low-solubility, bioavailability, and biocompatibility issues. In this scenario, nanotechnological interventions provide a multifaceted platform for targeted delivery of bioactive compounds by slow and sustained release of drug-like compounds. The unique physico-chemical properties, biocompatibility and eco-friendly nature of bioinspired nanostructures has revolutionized the field of biology to eradicate microbial infections and biofilm-related complications. The green-nanotechnology based metal and metal oxide nanoparticles and polymeric nanoparticles have been regularly employed for antimicrobial and antibiofilm applications without causing damage to host tissues. The implications of these nanoparticles toward achieving sustainability in agriculture by providing systemic resistance against a variety of phytopathogens therefore plays crucial role in growth and crop productivity. Also the advent of smart and hybrid nanomaterials such as metal-based polymer nanocomposites, lipid-based nanomaterials and liposomes have the inherent potential to eradicate bacterial biofilm-related infections in an efficient manner. The recent development of carbon-based nanomaterials such as carbon nanotubes (CNTs) and silica based nanomaterials such as mesoporous silica nanoparticles (MSNs) also exploit a target of dreadful healthcare conditions such as cancer, immunomodulatory diseases, and microbial infections, as well as biofilm-related issues owing to their stability profile, biocompatibility, and unique physio-chemical properties. Recently novel physical approaches such as photothermal therapy (PTT) and antimicrobial photodynamic therapy (aPDT) also revolutionized conventional strategies and are engaged in eradicating microbial biofilm-related infections and related health consequences. These promising advancements in the development of novel strategies to treat microbial infections and biofilm-related multidrug resistance (MDR) phenomenon may provide new avenues and aid to conventional antimicrobial therapeutics.
Microbiology. --- Nanotechnology. --- Plant breeding. --- Plant genetics. --- Microbial genetics. --- Microbial genomics. --- Plant systematics. --- Plant taxonomy. --- Plant Breeding/Biotechnology. --- Plant Genetics and Genomics. --- Microbial Genetics and Genomics. --- Plant Systematics/Taxonomy/Biogeography. --- Botanical classification --- Botanical systematics --- Botanical taxonomy --- Botany --- Classification --- Plant biosystematics --- Plant classification --- Plant systematics --- Plant taxonomy --- Systematic botany --- Systematics (Botany) --- Taxonomy, Plant --- Plant taxonomists --- Genomics --- Microbial genetics --- Microorganisms --- Genetics --- Microbiology --- Plants --- Crops --- Agriculture --- Breeding --- Molecular technology --- Nanoscale technology --- High technology --- Microbial biology --- Biology --- Nanotechnology --- Research. --- Microbiological research --- Microbiologia agrícola --- Microorganismes patògens --- Nanotecnologia --- Enginyeria molecular --- Tecnologia molecular --- Alta tecnologia --- Electrònica molecular --- Espintrònica --- Materials nanoestructurats --- Nanoelectrònica --- Nanolitografia --- Nanomedicina --- Nanoquímica --- Patògens --- Microorganismes --- Bacteris patògens --- Fongs patògens --- Microorganismes fitopatògens --- Protozous patògens --- Microbiologia mèdica --- Virulència (Microbiologia) --- Microbiologia --- Bacteriologia agrícola --- Plant biotechnology. --- Plant Biotechnology. --- Plant Genetics. --- Microbial Genetics. --- Plant Evolution. --- Evolution. --- Plant evolution --- Evolution (Biology) --- Crop biotechnology --- Agricultural biotechnology --- Phylogeny --- Biotechnology
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This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.
Microbiology. --- Medical microbiology. --- Animal models in research. --- Infectious diseases. --- Medical Microbiology. --- Animal Models. --- Infectious Diseases. --- Microbial biology --- Biology --- Microorganisms --- Animal experimentation --- Biological models --- Laboratory animals --- Research --- Pathogenic microorganisms. --- Disease-causing microorganisms --- Micro-organisms, Pathogenic --- Pathogens --- Medical microbiology --- Virulence (Microbiology) --- Biofilms. --- Drug Resistance, Microbial. --- Virulence Factors. --- Pathogenicity Factors --- Factors, Pathogenicity --- Factors, Virulence --- Virulence --- Antimicrobial Drug Resistance --- Antibiotic Resistance --- Antibiotic Resistance, Microbial --- Antimicrobial Drug Resistances --- Drug Resistances, Microbial --- Resistance, Antibiotic --- Microbial Sensitivity Tests --- Biofilm --- Dental Deposits --- Prosthesis-Related Infections --- Adhesins, Bacterial --- Biofouling --- Pathogenicity Factor --- Virulence Factor --- Factor, Pathogenicity --- Factor, Virulence --- Microorganismes patògens --- Resistència als medicaments --- Farmacoresistència --- Farmacologia --- Resistència a la insulina --- Efecte dels medicaments sobre els microorganismes --- Patògens --- Microorganismes --- Bacteris patògens --- Fongs patògens --- Microorganismes fitopatògens --- Protozous patògens --- Microbiologia mèdica --- Virulència (Microbiologia)
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This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.
Pharmacology. --- Human physiology. --- Nanotechnology. --- Animal models in research. --- Pharmacology/Toxicology. --- Human Physiology. --- Animal Models. --- Animal experimentation --- Biological models --- Laboratory animals --- Research --- Molecular technology --- Nanoscale technology --- High technology --- Human biology --- Medical sciences --- Physiology --- Human body --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Nanoparticles --- Toxicology. --- Nanostructured materials --- Particles --- Nano-particles --- NPs (Nanoparticles) --- Nanoscale particles --- Nanotoxicologia --- Nanotecnologia --- Ciències de la salut --- Biomedicina --- Ciències biomèdiques --- Ciències mèdiques --- Ciències de la vida --- Fisiologia humana --- Microbiologia mèdica --- Neurociències --- Enginyeria molecular --- Tecnologia molecular --- Alta tecnologia --- Electrònica molecular --- Espintrònica --- Materials nanoestructurats --- Nanoelectrònica --- Nanolitografia --- Nanomedicina --- Nanoquímica --- Toxicitat dels nanomaterials --- Toxicitat de les nanopartícules
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In the pursuit of technological advancement in the field of biotechnology and pharmaceutical industries to counteract health issues, bacterial infections remain a major cause of morbidity and mortality. The ability of bacterial pathogens to form biofilms further agglomerates the situation by showing resistance to conventional antibiotics. To overcome this serious issue, bioactive metabolites and other natural products were exploited to combat bacterial infections and biofilm-related health consequences. Natural products exhibited promising results in vitro, however; their efficacy in in vivo conditions remain obscured due to their low-solubility, bioavailability, and biocompatibility issues. In this scenario, nanotechnological interventions provide a multifaceted platform for targeted delivery of bioactive compounds by slow and sustained release of drug-like compounds. The unique physico-chemical properties, biocompatibility and eco-friendly nature of bioinspired nanostructures has revolutionized the field of biology to eradicate microbial infections and biofilm-related complications. The green-nanotechnology based metal and metal oxide nanoparticles and polymeric nanoparticles have been regularly employed for antimicrobial and antibiofilm applications without causing damage to host tissues. The implications of these nanoparticles toward achieving sustainability in agriculture by providing systemic resistance against a variety of phytopathogens therefore plays crucial role in growth and crop productivity. Also the advent of smart and hybrid nanomaterials such as metal-based polymer nanocomposites, lipid-based nanomaterials and liposomes have the inherent potential to eradicate bacterial biofilm-related infections in an efficient manner. The recent development of carbon-based nanomaterials such as carbon nanotubes (CNTs) and silica based nanomaterials such as mesoporous silica nanoparticles (MSNs) also exploit a target of dreadful healthcare conditions such as cancer, immunomodulatory diseases, and microbial infections, as well as biofilm-related issues owing to their stability profile, biocompatibility, and unique physio-chemical properties. Recently novel physical approaches such as photothermal therapy (PTT) and antimicrobial photodynamic therapy (aPDT) also revolutionized conventional strategies and are engaged in eradicating microbial biofilm-related infections and related health consequences. These promising advancements in the development of novel strategies to treat microbial infections and biofilm-related multidrug resistance (MDR) phenomenon may provide new avenues and aid to conventional antimicrobial therapeutics.
Systematics. Taxonomy. Nomenclature --- Genetics --- General microbiology --- Plant genetics. Plant evolution --- Botany --- Electrical engineering --- Agriculture. Animal husbandry. Hunting. Fishery --- systematische plantkunde --- nanotechniek --- biogeografie --- bevolking --- microbiologie --- genetica --- planten
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This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.
Animal physiology. Animal biophysics --- History of human medicine --- Human physiology --- Electrical engineering --- mens-dier vergelijkend onderzoek --- nanotechniek --- farmacologie --- fysiologie --- proefdieren
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This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.
Choose an application
Systematics. Taxonomy. Nomenclature --- Genetics --- General microbiology --- Plant genetics. Plant evolution --- Botany --- Electrical engineering --- Agriculture. Animal husbandry. Hunting. Fishery --- systematische plantkunde --- nanotechniek --- biogeografie --- bevolking --- microbiologie --- genetica --- planten
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Animal physiology. Animal biophysics --- History of human medicine --- Human physiology --- Electrical engineering --- mens-dier vergelijkend onderzoek --- nanotechniek --- farmacologie --- fysiologie --- proefdieren
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