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The question of how alcohol alters mood states and why this may end up becoming an addiction has puzzled alcohol researchers for decades. In this volume, a group of highly distinguished experts and leaders in alcohol addiction research presents our current state of knowledge and remaining research challenges, as well as interesting viewpoints on future research directions aimed to stimulate communication and convergence between clinical and preclinical researchers, and to renew interest in the vibrant field of alcohol addiction research among a broad scientifically minded audience. Five Current Topics are discussed in this volume: Neurobiological mechanisms of alcoholism, Genetics, Clinical phenotypes and their preclinical models, Brain imaging, and Translational approaches for treatment development, both pharmacological and non-pharmacological. These areas have in our opinion substantially brought alcohol research forward and influenced our thinking about how to reach our common paramount goal, namely to offer effective treatment solutions for an extensive group of patients with largely unmet medical needs.

Alcoholism. --- Alcohol-Related disorders -- Genetics. --- Alcohol-Related disorders -- Physiopathology. --- Alcoholism --- Neurosciences --- Substance-Related Disorders --- Biology --- Catecholamines --- Diseases --- Biological Science Disciplines --- Mental Disorders --- Amines --- Biogenic Monoamines --- Biogenic Amines --- Natural Science Disciplines --- Organic Chemicals --- Psychiatry and Psychology --- Disciplines and Occupations --- Chemicals and Drugs --- Dopamine --- Neurobiology --- Alcohol-Related Disorders --- Genetics --- Medicine --- Psychiatry --- Health & Biological Sciences --- Substance Abuse Disorders --- Neurology --- Alcohol --- Neuropsychology. --- Neuropsychopharmacology. --- Physiological aspects. --- Neuro-psychopharmacology --- Medicine. --- Neurosciences. --- Psychiatry. --- Psychopharmacology. --- Biomedicine. --- Neuropharmacology --- Psychopharmacology --- Neurophysiology --- Psychophysiology --- Drinking alcohol --- Grain alcohol --- Potable alcohol --- Intoxicants --- Alcohols --- Behavioral pharmacology --- Drugs --- Chemotherapy --- Pharmacology --- Psychotropic drugs --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Psychotropic effects

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Pharmacology. Therapy --- Psychiatry --- Neuropathology --- neurologie --- psychiatrie --- farmacologie --- toxicologie

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Alcoholism is a pathological behavioural syndrome, characterised by comp- sive alcohol use, craving and relapses, even recurring after many years of abstinence. It is suggested that chronic alcohol abuse leads to persistent changes within several neurochemical pathways in the brain and furthermore that an imprinted drug and addiction memory may scarcely be extinguished. Hence, the question arises as to whether there ought to be a reasonable hope that pharmacological drugs will be developed that interfere with an addiction memory, and as a result, finally lead to a cure? In this book, leading preclinical and clinical experts in the field of alcohol relapse prevention strive to furnish an answer to this question. None of the researchers or clinicians believes in a magic bullet that will be of help to all alcoholic patients in overcoming this disease. However, there is now convi- ing evidence demonstrating that specific subpopulations of alcoholic patients experience satisfactory benefit from currently available treatments. Today we have two medications for relapse prevention on the market - acamprosate and naltrexone. Although, currently, only a minority of alcoholic patients benefit from these medications, the approval of these compounds may be considered a hallmark in the field of psychopharmacology, even comparable to the era when the first antidepressant compounds were introduced. In recent years we have been witnessing an enormous growth in the science and knowledge regarding the field of relapse prevention.

Alcoholism --- Alcoholism --- Alcohol Deterrents --- Recurrence --- Therapies, Investigational