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Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes.  While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract.   Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum.    This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.

Skin --- Medical genetics. --- Evidence-based medicine. --- Diseases --- Genetic aspects. --- EBM (Medicine) --- Evidence-based healthcare --- Clinical medicine --- Systematic reviews (Medical research) --- Clinical genetics --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genodermatology --- Genodermatoses --- Decision making --- Genetic aspects --- Dermatology. --- Allergy. --- Pneumology. --- Ophthalmology. --- Allergology. --- Pneumology/Respiratory System. --- Medicine --- Eye --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Respiratory organs—Diseases.

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Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes.  While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract.   Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum.    This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.

Physiology of the respiratory system --- Allergy --- Pathology of the respiratory system --- Pathological dermatology --- Ophthalmology --- dermatologie --- toxicologie --- pneumologie --- astma --- oftalmologie --- allergieën

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This book is a quick guide for clinicians, specialists, and residents. It provides a concise overview of the practical aspects of contact dermatitis, supplying the tools to allow a fast and reliable diagnosis. The book describes the clinical features of contact dermatitis, explains how to make an exposure assessment and covers other essentials in the diagnostic work. Information is presented on testing with patients’ own products and overviews are provided on the allergens contained in various products. In addition, a helpful list of the most frequent allergens is included. The authors are leading practitioners in the field, and their expertise has enabled the compilation of an approachable text supplemented by a large number of full color illustrations, tables and check lists. This book will help the reader to gain a better understanding of the subject and to achieve greater competence in everyday practice.

Dermatology --- Medicine --- Health & Biological Sciences --- Contact dermatitis --- Contact hypersensitivity --- Contact sensitivity --- Dermatitis, Contact --- Dermatitis venenata --- Hypersensitivity, Contact --- Delayed hypersensitivity --- Skin --- Inflammation --- Dermatology. --- Allergy. --- Allergology. --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Diseases